Mechanism of action of vigabatrin: correcting misperceptions (Q37953574)

25 August 2017

Mechanism of action of vigabatrin: correcting misperceptions (English)

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25 August 2017

E Ben-Menachem

1

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25 August 2017

1 January 2011

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Acta neurologica Scandinavica. Supplementum

25 August 2017

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25 August 2017

192

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25 August 2017

5-15

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25 August 2017

Vigabatrin: 2008 update

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin: a comprehensive review of drug properties including clinical updates following recent FDA approval

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Non-vision adverse events with vigabatrin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Understanding and interpreting vision safety issues with vigabatrin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Severe persistent visual field constriction associated with vigabatrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Acute effects of gamma-vinyl-GABA on low-magnesium evoked epileptiform activity in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The mechanisms of action of commonly used antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

gamma-Aminobutyric acid outside the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Mechanisms by which human blood platelets accumulate glycine, gaba and amino acid precursors of putative neurotransmitters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

A role of GABA analogues in the treatment of neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The GABA transporter and its inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

GABA transporters as targets for new drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The 'ABC' of GABA receptors: a brief review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

21 January 2018

GABAA receptor channels

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https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Key factors in the discovery and development of new antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Mechanisms of action of antiepileptic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Basic mechanisms of gabitril (tiagabine) and future potential developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Drugability of extracellular targets: discovery of small molecule drugs targeting allosteric, functional, and subunit-selective sites on GPCRs and ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Molecular composition of GABAC receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

?-Aminobutyric Acid and Benzodiazepine Binding Sites in Audiogenic Seizure-Susceptible Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Increased numbers of GABAergic neurons occur in the inferior colliculus of an audiogenic model of genetic epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

A regional increase in the number of hippocampal GABAergic neurons and terminals in the seizure-sensitive gerbil.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Changes in GABA-immunoreactive cell density during motor focal epilepsy induced by cobalt in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The inhibitory action of beta-hydroxy-gamma-aminobutyric acid upon the seizure following stimulation of the motor cortex of the dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

GABAergic mechanisms in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

"Central" and "peripheral" benzodiazepine receptors: Opposite changes in human epileptogenic tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

In-vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Antiepileptic drug therapy the story so far.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

GABAergic drugs in the treatment of epilepsy: modern or outmoded?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Effect of elevated brain GABA concentrations on the actions of bicuculline and picrotoxin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Serendipity and psychopharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Meta-analysis of European placebo controlled studies of vigabatrin in drug resistant epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Metabolic inhibitors and subcellular distribution of GABA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Elevated endogenous GABA concentration attenuates glutamate-glutamine cycling between neurons and astroglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Pharmacokinetics of the individual enantiomers of vigabatrin (gamma-vinyl GABA) in epileptic children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Psychophysiological and psychometric studies after manipulating the GABA system by vigabatrin, a GABA-transaminase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Effects of single doses of vigabatrin on CSF concentrations of GABA, homocarnosine, homovanillic acid and 5-hydroxyindoleacetic acid in patients with complex partial epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Forced normalization at the interface between epilepsy and psychiatry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, ?-acetylenic GABA (4-amino-hex-5-ynoic acid) and ?-vinyl GABA (4-amino-hex-5-enoic acid)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

gamma-Vinyl GABA in endopiriform area suppresses kindled amygdala seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Double-blind study of gamma-vinyl GABA in patients with refractory epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Double-blind, placebo-controlled study of vigabatrin (gamma-vinyl GABA) in drug-resistant epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin in the treatment of epilepsy: a double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Adjuvant vigabatrin in refractory epilepsy: a ceiling to effective dosage in individual patients?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Effects of vigabatrin on partial seizures and cognitive function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Dose-Response Study of Vigabatrin as add-on therapy in patients with uncontrolled complex partial seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin therapy for refractory complex partial seizures: review of major European trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin therapy for refractory complex partial seizures: review of clinical trial experience in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin for the treatment of infantile spasms: final report of a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin therapy for infantile spasms: review of major trials in Europe, Canada, and the United States; and recommendations for dosing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Efficacy and safety of vigabatrin in the long-term treatment of refractory epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin in the treatment of epilepsy: a long-term follow-up study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Double-blind dose reduction study of vigabatrin in complex partial epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Cellular compartments of GABA in brain and their relationship to anticonvulsant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy and disorders of motor control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin withdrawal randomized study in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The blood-retinal barrier: structure and functional significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The effect of vigabatrin on brain and platelet GABA-transaminase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Randomized trial of vigabatrin in patients with infantile spasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Passage of amino acids and glucose across the blood-brain barrier in patients with hepatic encephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Vigabatrin in complex partial seizures: a long-term study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

Hippocampal GABA transporter function in temporal-lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0404.2011.01596.X

10.1111/J.1600-0404.2011.01596.X

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

22061176