Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions (Q37955275)

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English	Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 August 2017

Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions (English)

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Europe PubMed Central

PubMed publication ID

25 August 2017

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Robert E Drolet

1

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Europe PubMed Central

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25 August 2017

John M Sanders

2

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Europe PubMed Central

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25 August 2017

Jonathan T Kern

3

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Europe PubMed Central

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25 August 2017

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11 November 2011

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Europe PubMed Central

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25 August 2017

Journal of Neurogenetics

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Europe PubMed Central

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25 August 2017

25

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Europe PubMed Central

PubMed publication ID

25 August 2017

4

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Europe PubMed Central

PubMed publication ID

25 August 2017

140-151

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Europe PubMed Central

PubMed publication ID

25 August 2017

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Translation initiator EIF4G1 mutations in familial Parkinson disease

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

14-3-3 proteins: structure, function, and regulation

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

The MAP1 family of microtubule-associated proteins

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Identification of the autophosphorylation sites of LRRK2.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

eIF4E: new family members, new binding partners, new roles

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

14-3-3 proteins are promising LRRK2 interactors

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Olfactory dysfunction in LRRK2 G2019S mutation carriers

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

A conserved protonation-dependent switch controls drug binding in the Abl kinase

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Parkinson's Disease: Genetics and Pathogenesis

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

4E-BP functions as a metabolic brake used under stress conditions but not during normal growth

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2011.627072

21 January 2018

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10.3109/01677063.2011.627072

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Europe PubMed Central

PubMed publication ID

25 August 2017

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25 August 2017

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