Are we moving in the right direction with osteoarthritis drug discovery? (Q37956680)

25 August 2017

Are we moving in the right direction with osteoarthritis drug discovery? (English)

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25 August 2017

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1

Jan Bondeson

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PubMed ID

22087738

25 August 2017

language of work or name

English

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publication date

16 November 2011

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Expert Opinion on Therapeutic Targets

25 August 2017

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25 August 2017

15

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25 August 2017

12

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25 August 2017

1355-1368

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The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?

25 August 2017

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed?

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Activated synovial macrophages as targets for osteoarthritis drug therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Osteoarthritis year 2010 in review: pathomechanisms

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Pharmacologic therapy for osteoarthritis--the era of disease modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthri

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Are cytokines involved in osteoarthritic pathophysiology?

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Synovial tissue inflammation in early and late osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Is IL-1 a good therapeutic target in the treatment of arthritis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Animal models of arthritis in NOS2-deficient mice.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Advances in the development of novel aggrecanase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Intraarticular treatments for osteoarthritis: new perspectives

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

The protective effect of OP-1 on articular cartilage in the development of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Translating molecular insights in autoimmunity into effective therapy.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.636740

Biomarkers in osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.636740

10.1517/14728222.2011.636740

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

22087738