CHO cells in biotechnology for production of recombinant proteins: current state and further potential (Q37967218)

26 August 2017

CHO cells in biotechnology for production of recombinant proteins: current state and further potential (English)

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26 August 2017

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3

Gyun Min Lee

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26 August 2017

Jee Yon Kim

1

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PubMed ID

22159888

26 August 2017

Yeon-Gu Kim

series ordinal

2

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PubMed ID

22159888

26 August 2017

language of work or name

English

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publication date

9 December 2011

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Applied Microbiology and Biotechnology

26 August 2017

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26 August 2017

93

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26 August 2017

917-930

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26 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s00253-011-3758-5

26 August 2017

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A DIGE approach for the assessment of differential expression of the CHO proteome under sodium butyrate addition: Effect of Bcl-x(L) overexpression

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Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin

21 January 2018

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Limitations to the comparative proteomic analysis of thrombopoietin producing Chinese hamster ovary cells treated with sodium butyrate

21 January 2018

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Stability of protein production from recombinant mammalian cells

21 January 2018

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Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7.

21 January 2018

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An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

21 January 2018

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The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein

21 January 2018

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Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells.

21 January 2018

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Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line

21 January 2018

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Fermentanomics: monitoring mammalian cell cultures with NMR spectroscopy

21 January 2018

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Meganuclease-driven targeted integration in CHO-K1 cells for the fast generation of HTS-compatible cell-based assays

21 January 2018

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Proteomic profiling of a high-producing Chinese hamster ovary cell culture

21 January 2018

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Metabolic changes during cell growth inhibition by p27 overexpression

21 January 2018

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Bcl-x(L) mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells

21 January 2018

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Enhancement of recombinant protein production in Chinese hamster ovary cells through anti-apoptosis engineering using 30Kc6 gene

21 January 2018

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Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture

21 January 2018

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Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II.

21 January 2018

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Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media.

21 January 2018

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Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells

21 January 2018

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BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells

21 January 2018

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Over-expression of hTERT in CHO K1 results in decreased apoptosis and reduced serum dependency

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effect of PDI overexpression on recombinant protein secretion in CHO cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Comparative transcriptional analysis of mouse hybridoma and recombinant Chinese hamster ovary cells undergoing butyrate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

A novel cytostatic process enhances the productivity of Chinese hamster ovary cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Use of the chicken lysozyme 5' matrix attachment region to generate high producer CHO cell lines.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Genomics and proteomics in process development: opportunities and challenges

21 January 2018

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25 years of recombinant proteins from reactor-grown cells - where do we go from here?

21 January 2018

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Autophagy and apoptosis of recombinant Chinese hamster ovary cells during fed-batch culture: effect of nutrient supplementation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Cytochalasin D can improve heterologous protein productivity in adherent Chinese hamster ovary cells.

21 January 2018

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An efficient and targeted gene integration system for high-level antibody expression

21 January 2018

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Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effect of doxycycline-regulated ERp57 expression on specific thrombopoietin productivity of recombinant CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog

21 January 2018

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Developing genomic platforms for Chinese hamster ovary cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells

21 January 2018

1 reference

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The generation of stable, high MAb expressing CHO cell lines based on the artificial chromosome expression (ACE) technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Bcl-xL overexpression does not enhance specific erythropoietin productivity of recombinant CHO cells grown at 33 degrees C and 37 degrees C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Improved recombinant gene expression in CHO cells using matrix attachment regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Efficient selection of stable chinese hamster ovary (CHO) cell lines for expression of recombinant proteins by using human interferon beta SAR element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

A simple analysis system for the estimation of recombination efficiency using fluorescence-activated cell sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effect of XIAP overexpression on sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells producing erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Proteomic understanding of intracellular responses of recombinant Chinese hamster ovary cells cultivated in serum-free medium supplemented with hydrolysates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Construction of engineered CHO strains for high-level production of recombinant proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Identification and expression analysis of miRNAs during batch culture of HEK-293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Differential protein expression following low temperature culture of suspension CHO-K1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

cMyc increases cell number through uncoupling of cell division from cell size in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

A proteomic study of cMyc improvement of CHO culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effects of ammonium and lactate on growth and metabolism of a recombinant Chinese hamster ovary cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Development of apoptosis‐resistant dihydrofolate reductase‐deficient Chinese hamster ovary cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Two-dimensional electrophoresis of proteins as a tool in the metabolic engineering of cell cycle regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Deregulated expression of cloned transcription factor E2F-1 in Chinese hamster ovary cells shifts protein patterns and activates growth in protein-free medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Proteome analysis of antibody-expressing CHO cells in response to hyperosmotic pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

E2F-1 overexpression increases viable cell density in batch cultures of Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

p27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: thrombopoietin and antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

MicroRNAs as targets for engineering of CHO cell factories.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Systems biotechnology of mammalian cell factories

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Overexpression of GADD34 enhances production of recombinant human antithrombin III in Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Bacterial artificial chromosome library for genome-wide analysis of Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Recombinant cyclin E expression activates proliferation and obviates surface attachment of chinese hamster ovary (CHO) cells in protein-free medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Study of caspase inhibitors for limiting death in mammalian cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Overexpression of taurine transporter in Chinese hamster ovary cells can enhance cell viability and product yield, while promoting glutamine consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Influence of bcl-2 on cell death during the cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Vesicle trafficking: pleasure and pain from SM genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Identification of cellular changes associated with increased production of human growth hormone in a recombinant Chinese hamster ovary cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Engineering cell metabolism for high-density cell culture via manipulation of sugar transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Transcriptional profiling of apoptotic pathways in batch and fed-batch CHO cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Targeting early apoptotic genes in batch and fed-batch CHO cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Enhancing effect of low culture temperature on specific antibody productivity of recombinant Chinese hamster ovary cells: clonal variation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Specific inhibition of caspase-8 and -9 in CHO cells enhances cell viability in batch and fed-batch cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Development of stable cell lines for production or regulated expression using matrix attachment regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Metabolic characteristics of recombinant Chinese hamster ovary cells expressing glutamine synthetase in presence and absence of glutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

Difference gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3758-5

10.1007/S00253-011-3758-5

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22159888