Structure, function and selective inhibition of bacterial acetyl-coa carboxylase (Q37969915)

26 August 2017

Structure, function and selective inhibition of bacterial acetyl-coa carboxylase (English)

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26 August 2017

S W Polyak

1

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26 August 2017

A D Abell

2

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26 August 2017

M C J Wilce

3

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26 August 2017

L Zhang

4

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26 August 2017

G W Booker

5

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26 August 2017

language of work or name

English

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publication date

20 December 2011

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Applied Microbiology and Biotechnology

26 August 2017

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26 August 2017

93

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26 August 2017

3

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26 August 2017

983-992

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https://scigraph.springernature.com/pub.10.1007/s00253-011-3796-z

26 August 2017

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cites work

Coordinate expression of the acetyl coenzyme A carboxylase genes, accB and accC, is necessary for normal regulation of biotin synthesis in Escherichia coli

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

BIOTIN METABOLISM IN PLANTS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Method for quantitative protein-ligand affinity measurements in compound mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Crystal Structures and Mutational Analyses of Acyl-CoA Carboxylase β Subunit of Streptomyces coelicolor ,

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Structure of the biotinyl domain of acetyl-coenzyme A carboxylase determined by MAD phasing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Essentiality of FASII pathway for Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Current understanding of fatty acid biosynthesis and the acyl carrier protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Discovery and optimization of antibacterial AccC inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Structural and Biochemical Studies on the Regulation of Biotin Carboxylase by Substrate Inhibition and Dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Community-associated meticillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Antibiotic discovery in the twenty-first century: current trends and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Antibiotics for emerging pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Novel bacterial acetyl coenzyme A carboxylase inhibitors with antibiotic efficacy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Fatty acid biosynthesis in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Comprehensive transposon mutant library of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Function of Escherichia coli biotin carboxylase requires catalytic activity of both subunits of the homodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

The lethal phenotype caused by null mutations in the Escherichia coli htrB gene is suppressed by mutations in the accBC operon, encoding two subunits of acetyl coenzyme A carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Structure of the biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus at 2.2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

A tale of two functions: enzymatic activity and translational repression by carboxyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Microbiology. Desperately seeking new antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Global transposon mutagenesis and essential gene analysis of Helicobacter pylori

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Protein kinases as antibacterial targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Antibacterial targets in fatty acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3796-Z

10.1007/S00253-011-3796-Z

21 January 2018

Identifiers

DOI

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26 August 2017

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