The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models (Q37973270)

26 August 2017

The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models (English)

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26 August 2017

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Hiroko Oshima

1

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PubMed ID

22218775

26 August 2017

Masanobu Oshima

series ordinal

2

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26 August 2017

5 January 2012

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Journal of Gastroenterology

26 August 2017

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26 August 2017

47

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26 August 2017

2

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26 August 2017

97-106

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Infections as a major preventable cause of human cancer

26 August 2017

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

The global health burden of infection-associated cancers in the year 2002

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

21 January 2018

Inflammation and cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Cancer-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Immunity, Inflammation, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Aspirin use and reduced risk of fatal colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

21 January 2018

Eicosanoids and cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

The role of COX-2 in intestinal inflammation and colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

APC mutations occur early during colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

A novel inflammation‐related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Mouse models of gastric tumors: Wnt activation and PGE2 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

COX selectivity and animal models for colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Cyclooxygenase‐2 and gastric carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Prostaglandin E₂ signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Toll-like receptors and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Mast cells are an essential hematopoietic component for polyp development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Interleukin-6: from basic science to medicine--40 years in immunology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Systematic review of the association between circulating interleukin-6 (IL-6) and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

NF-κB and STAT3 - key players in liver inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Macrophage diversity enhances tumor progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Aspirin and the Risk of Colorectal Cancer in Women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-011-0523-6

Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice

21 January 2018

1 reference

12 December 2020

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis

1 reference

12 December 2020

CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice

1 reference

12 December 2020

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

1 reference

12 December 2020

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice

1 reference

12 December 2020

Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice

1 reference

12 December 2020

Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.

1 reference

12 December 2020

The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia

1 reference

12 December 2020

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1 reference

12 December 2020

Tumour necrosis factor and cancer

1 reference

12 December 2020

Expression of cyclooxygenase-2 in human gastric carcinoma

1 reference

12 December 2020

Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer

1 reference

12 December 2020

Helicobacter pylori infection and gastric cancer

1 reference

12 December 2020

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

1 reference

12 December 2020

Malignancies in inflammatory bowel disease: fact or fiction?

1 reference

12 December 2020

The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development.

1 reference

12 December 2020

beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer.

1 reference

12 December 2020

Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis

1 reference

12 December 2020

Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps

1 reference

12 December 2020

Polyps wrap mast cells and Treg within tumorigenic tentacles

1 reference

12 December 2020

Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps

1 reference

12 December 2020

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

1 reference

12 December 2020

COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps

1 reference

12 December 2020

10.1007/S00535-011-0523-6

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22218775