Isoflavones as a smart curer for non-alcoholic fatty liver disease and pathological adiposity via ChREBP and Wnt signaling (Q37974003)

26 August 2017

Isoflavones as a smart curer for non-alcoholic fatty liver disease and pathological adiposity via ChREBP and Wnt signaling (English)

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metabolic dysfunction–associated steatotic liver disease

26 August 2017

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based on heuristic

inferred from title

non-alcoholic fatty liver

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Mi-Hyun Kim

1

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PubMed ID

22227283

26 August 2017

Kyung-Sun Kang

series ordinal

2

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PubMed ID

22227283

26 August 2017

language of work or name

English

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publication date

28 December 2011

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26 August 2017

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26 August 2017

54 Suppl

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26 August 2017

S57-63

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The natural history of nonalcoholic fatty liver disease: a population-based cohort study

26 August 2017

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https://api.crossref.org/works/10.1016%2FJ.YPMED.2011.12.018

Plasma concentrations of phyto-oestrogens in Japanese men

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Effects of testosterone on fat cell lipolysis. Species differences and possible role in polycystic ovarian syndrome

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Antioxidant activities of isoflavones and their biological metabolites in a liposomal system

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Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats.

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Regulation of Wnt signaling during adipogenesis

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice

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The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

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Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein

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The role of C/EBP genes in adipocyte differentiation.

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Role of soy isoflavones in the hypotriglyceridemic effect of soy protein in the rat

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Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

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Current therapeutic strategies in non-alcoholic fatty liver disease.

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New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

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Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population

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Evidence for a role of developmental genes in the origin of obesity and body fat distribution

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Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage

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Genistein inhibits CCAAT/enhancer-binding protein beta (C/EBPbeta) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression

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The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

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Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase

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Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

7 January 2021

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Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription

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Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States)

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Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes

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Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein

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Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

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Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms.

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1 reference

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Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice.

7 January 2021

1 reference

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The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease

7 January 2021

1 reference

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Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis

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Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism.

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Changes in gene expression foreshadow diet-induced obesity in genetically identical mice

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Dickkopf-1 enhances migration of HEK293 cell by beta-catenin/E-cadherin degradation

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Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta

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Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets.

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Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

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Wnt10b inhibits development of white and brown adipose tissues

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Wnt signaling and human diseases: what are the therapeutic implications?

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Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

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Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor

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The expression of Wnt4 is regulated by estrogen via an estrogen receptor alpha-dependent pathway in rat pituitary growth hormone-producing cells

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Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance

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1 reference

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Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells

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1 reference

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The soy isoflavone genistein decreases adipose deposition in mice

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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

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Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway

7 January 2021

1 reference

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Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner

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1 reference

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Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen

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Inhibition of adipogenesis by Wnt signaling

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Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora

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Prevalence of fatty liver in children and adolescents.

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Dietary isoflavones: biological effects and relevance to human health

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Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells

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Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors

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Genistein restricts leptin secretion from rat adipocytes.

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Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence

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Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study

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Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

7 January 2021

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Obesity is associated with macrophage accumulation in adipose tissue

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Wnt10b inhibits obesity in ob/ob and agouti mice.

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1 reference

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Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.

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Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial

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1 reference

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Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.

7 January 2021

1 reference

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AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells

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1 reference

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Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP.

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Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways

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10.1016/J.YPMED.2011.12.018

7 January 2021

Identifiers

DOI

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26 August 2017

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PubMed ID

22227283