Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways (Q37979995)

26 August 2017

title

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways (English)

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26 August 2017

M Ruzzene

3

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Francesco Piazza

object named as

F Piazza

1

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Gianpietro Semenzato

object named as

G Semenzato

6

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author name string

S Manni

2

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26 August 2017

L A Pinna

4

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26 August 2017

C Gurrieri

5

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26 August 2017

publication date

13 January 2012

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26 August 2017

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26 August 2017

volume

26

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26 August 2017

issue

6

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26 August 2017

page(s)

1174-1179

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https://scigraph.springernature.com/pub.10.1038/leu.2011.385

26 August 2017

exact match

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cites work

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One-thousand-and-one substrates of protein kinase CK2?

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Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality

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Gene targeting of CK2 catalytic subunits

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When pathways collide: collaboration and connivance among signalling proteins in development.

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CK2 as a positive regulator of Wnt signalling and tumourigenesis

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Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells

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CK2 controls the recruitment of Wnt regulators to target genes in vivo

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CK2 functionally interacts with AKT/PKB to promote the β-catenin-dependent expression of survivin and enhance cell survival.

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The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis.

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Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

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The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1

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Tenets of PTEN tumor suppression

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

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Protein kinase CK2 phosphorylates and upregulates Akt/PKB.

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Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

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Constitutive c-Myb amino-terminal phosphorylation and DNA binding activity uncoupled during entry and passage through the cell cycle

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Sp1 phosphorylation and its regulation of gene transcription.

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CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor.

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The Genetic Basis of Autoimmune Disease in MRL-lpr/lpr Mice

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p53 deficiency and misexpression of protein kinase CK2alpha collaborate in the development of thymic lymphomas in mice

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Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis

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Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

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CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy

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Multiple myeloma cell survival relies on high activity of protein kinase CK2.

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Protein kinases in human leukemic cells

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Multiple forms of protein kinase CK2 present in leukemic cells: in vitro study of its origin by proteolysis.

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Protein kinase CK2alpha is a target for the Abl and Bcr-Abl tyrosine kinases

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Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization

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Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.

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7 January 2021

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Identifiers

DOI

10.1038/LEU.2011.385

1 reference

Dimensions Publication ID

26 August 2017

1012402617

0 references

1 reference