The therapeutic potential of GPR119 agonists for type 2 diabetes (Q37980173)

26 August 2017

The therapeutic potential of GPR119 agonists for type 2 diabetes (English)

1 reference

26 August 2017

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Takahide Ohishi

1

1 reference

PubMed ID

22292451

26 August 2017

Shigeru Yoshida

series ordinal

2

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PubMed ID

22292451

26 August 2017

language of work or name

English

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publication date

3 February 2012

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Expert Opinion on Investigational Drugs

26 August 2017

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26 August 2017

21

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26 August 2017

3

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26 August 2017

321-328

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Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

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Diabetic retinopathy. A clinical overview

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Nephropathy in patients with type 2 diabetes mellitus

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Pathogenesis of NIDDM. A balanced overview

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Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?

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Five stages of evolving beta-cell dysfunction during progression to diabetes

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Pancreatic islet dysfunction in type 2 diabetes: a rational target for incretin-based therapies

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Lipotoxicity in human pancreatic islets and the protective effect of metformin

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Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

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Biology of incretins: GLP-1 and GIP

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Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

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Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives

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Identification of G protein-coupled receptor genes from the human genome sequence

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G-protein-coupled receptors: new approaches to maximise the impact of GPCRS in drug discovery

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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

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Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: predominant localization in pancreatic polypeptide-secreting PP-cells

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Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor

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A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release

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Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

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Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion

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The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function

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Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice

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The role of sulphonylureas in the management of type 2 diabetes mellitus

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AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes

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1 reference

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Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.

21 January 2018

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Minireview: transcriptional regulation in pancreatic development

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NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming

21 January 2018

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Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene

21 January 2018

1 reference

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Transcription factors regulating beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.657797

Pancreatic beta cells require NeuroD to achieve and maintain functional maturity

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Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells

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Cellular and molecular biology of the beta cell

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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells

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Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans

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Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119

21 January 2018

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2,5-Disubstituted pyridines as potent GPR119 agonists

21 January 2018

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Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor

21 January 2018

1 reference

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Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

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Exenatide and weight loss.

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Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome.

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Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms

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Liraglutide for weight loss in obese people

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The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size.

21 January 2018

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Free fatty acids and type 2 diabetes mellitus

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Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

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1 reference

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10.1517/13543784.2012.657797

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22292451