HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease (Q37980335)

26 August 2017

HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease (English)

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26 August 2017

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2

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26 August 2017

Helena Erlandsson Harris

series ordinal

1

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PubMed ID

22293756

26 August 2017

David S Pisetsky

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3

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PubMed ID

22293756

26 August 2017

language of work or name

English

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publication date

31 January 2012

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Nature Reviews Rheumatology

26 August 2017

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26 August 2017

8

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26 August 2017

195-202

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26 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2011.222

26 August 2017

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cites work

HMGB1 is a therapeutic target for sterile inflammation and infection

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

HMGB proteins and transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group protein-1 (HMG-1) is a unique activator of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Comparative analysis of the influence of the high-mobility group box 1 protein on DNA binding and transcriptional activation by the androgen, glucocorticoid, progesterone and mineralocorticoid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

HMGB1 interacts differentially with members of the Rel family of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

HMG-1 as a late mediator of endotoxin lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

HMGB1 is an endogenous immune adjuvant released by necrotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

The extracellular release of HMGB1 during apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Mechanisms of regulated unconventional protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Caspase-1-induced pyroptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Innate and adaptive immune responses to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

A high-sensitivity method for detection and measurement of HMGB1 protein concentration by high-affinity binding to DNA hemicatenanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Cyclophilin A release as a biomarker of necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Contribution of cyclophilin A to the regulation of inflammatory processes in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

HMGB1 develops enhanced proinflammatory activity by binding to cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Developments in the scientific understanding of lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

The type I interferon system in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High-mobility group box 1 release and redox regulation accompany regeneration and remodeling of skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Increased serum high mobility group box-1 level in Churg-Strauss syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

An elevated value of high mobility group box 1 is a potential marker for poor response to high-dose of intravenous immunoglobulin treatment in patients with Kawasaki syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Extracellular high-mobility group box 1 is increased in patients with Behçet's disease with intestinal involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High-mobility group box-1 protein (HMGB1) is increased in antineutrophilic cytoplasmatic antibody (ANCA)-associated vasculitis with renal manifestations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Serum Levels of HMGB1 in Postmenopausal Patients with Rheumatoid Arthritis: Associations with Proinflammatory Cytokines, Acute-phase Reactants, and Clinical Disease Characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Immunosuppressive effects of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

New high mobility group box 1 assay system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Factors masking HMGB1 in human serum and plasma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

PCA-ELISA: A sensitive method to quantify free and masked forms of HMGB1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box protein 1 (HMGB1)-partner molecule complexes enhance cytokine production by signaling through the partner molecule receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV-induced lesions of cutaneous lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-α and TNF-α in systemic lupus erythematosus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Autoantibodies to nonhistone chromosomal proteins HMG-1 and HMG-2 in sera of patients with juvenile rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Lupus antibodies to the HMGB1 chromosomal protein: epitope mapping and association with disease activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Multiple Effects of High Mobility Group Box Protein 1 in Skeletal Muscle Regeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjögren's syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Serum HMGB1 levels are increased in active Wegener's granulomatosis and differentiate between active forms of ANCA-associated vasculitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Correlation of serum level of high mobility group box 1 with the burden of granulomatous inflammation in granulomatosis with polyangiitis (Wegener's)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2011.222

Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22293756

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRRHEUM.2011.222

1 reference

26 August 2017

1 reference

PubMed ID

22293756