Inflammasomes in carcinogenesis and anticancer immune responses (Q37995072)

26 August 2017

Inflammasomes in carcinogenesis and anticancer immune responses (English)

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26 August 2017

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1

Laurence Zitvogel

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Guido Kroemer

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4

object named as

Guido Kroemer

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Lorenzo Galluzzi

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3

object named as

Lorenzo Galluzzi

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Oliver Kepp

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2

object named as

Oliver Kepp

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language of work or name

English

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publication date

18 March 2012

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26 August 2017

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26 August 2017

13

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26 August 2017

343-351

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26 August 2017

4

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26 August 2017

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Intracellular NOD-like receptors in host defense and disease

21 January 2018

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NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.

21 January 2018

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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

21 January 2018

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

21 January 2018

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The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

21 January 2018

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The inflammasome: an integrated view

21 January 2018

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Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Sensing and reacting to microbes through the inflammasomes

21 January 2018

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A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

21 January 2018

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Regulation of inflammasome signaling

21 January 2018

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Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

21 January 2018

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Molecular mechanisms of necroptosis: an ordered cellular explosion

21 January 2018

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Mitotic catastrophe: a mechanism for avoiding genomic instability.

21 January 2018

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Pyroptosis - a cell death modality of its kind?

21 January 2018

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Salmonella induces macrophage death by caspase-1-dependent necrosis.

21 January 2018

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Pyroptosis: host cell death and inflammation

21 January 2018

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Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles

21 January 2018

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Caspase-1-induced pyroptotic cell death

21 January 2018

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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

21 January 2018

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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

21 January 2018

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Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes

21 January 2018

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

21 January 2018

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Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

21 January 2018

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Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

21 January 2018

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

21 January 2018

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

21 January 2018

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Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

21 January 2018

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Discovery of a viral NLR homolog that inhibits the inflammasome

21 January 2018

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Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta

21 January 2018

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Constitutive aberrant endogenous interleukin-1 facilitates inflammation and growth in human melanoma.

21 January 2018

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Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component

21 January 2018

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Cancer as an overhealing wound: an old hypothesis revisited

21 January 2018

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Immunity, Inflammation, and Cancer

21 January 2018

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Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.

21 January 2018

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Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis

21 January 2018

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Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression

21 January 2018

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The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells

21 January 2018

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Cloning of a new cytokine that induces IFN-gamma production by T cells

21 January 2018

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Defective NK cell activity and Th1 response in IL-18-deficient mice

21 January 2018

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Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer

21 January 2018

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IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation

21 January 2018

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A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

21 January 2018

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Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

21 January 2018

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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

21 January 2018

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The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.

21 January 2018

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The Nlrp3 inflammasome: contributions to intestinal homeostasis

21 January 2018

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Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice

21 January 2018

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MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

21 January 2018

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Interleukin-1 receptor signaling protects mice from lethal intestinal damage caused by the attaching and effacing pathogen Citrobacter rodentium.

21 January 2018

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IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

21 January 2018

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In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites

21 January 2018

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IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.

21 January 2018

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The role of interleukin 1 in growth and metastasis of human cancer xenografts

21 January 2018

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Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth.

21 January 2018

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FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo

21 January 2018

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Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells

21 January 2018

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Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.

21 January 2018

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Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells

21 January 2018

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Innate instruction of adaptive immunity revisited: the inflammasome

21 January 2018

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Immune parameters affecting the efficacy of chemotherapeutic regimens

21 January 2018

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

21 January 2018

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Chemotherapy induces ATP release from tumor cells

21 January 2018

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Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

21 January 2018

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Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.

21 January 2018

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Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

21 January 2018

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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors

21 January 2018

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Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy

21 January 2018

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

21 January 2018

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Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors

21 January 2018

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Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

21 January 2018

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Extracellular adenosine triphosphate and adenosine in cancer.

21 January 2018

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P2X7 receptor polymorphism impairs extracellular adenosine 5'-triphosphate-induced interleukin-18 release from human monocytes

21 January 2018

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Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

21 January 2018

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Pharmacological manipulation of cell death: clinical applications in sight?

21 January 2018

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Thalidomide inhibits activation of caspase-1.

21 January 2018

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Identification of a primary target of thalidomide teratogenicity

21 January 2018

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

21 January 2018

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Interleukin-18: biology and role in the immunotherapy of cancer

21 January 2018

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Successful treatment of Castleman's disease with interleukin-1 receptor antagonist (Anakinra).

21 January 2018

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Recombinant human interleukin-1 receptor antagonist protects mice against acute doxorubicin-induced cardiotoxicity

21 January 2018

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Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome

21 January 2018

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Interleukin-1 receptor antagonist reduced apoptosis and attenuated intestinal mucositis in a 5-fluorouracil chemotherapy model in mice

21 January 2018

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Role of interleukin-1beta in postoperative cognitive dysfunction.

21 January 2018

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Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation.

21 January 2018

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The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.

21 January 2018

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IL-1 is required for tumor invasiveness and angiogenesis

21 January 2018

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

21 January 2018

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

21 January 2018

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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

21 January 2018

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Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses

21 January 2018

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Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis.

21 January 2018

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A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma risk

21 January 2018

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Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

21 January 2018

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

21 January 2018

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Cyst fluid interleukin-1beta (IL1beta) levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas.

21 January 2018

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Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

21 January 2018

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Is IL-6 the best pro-inflammatory biomarker of clinical outcomes of cancer cachexia?

21 January 2018

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Noninvasive detection of inflammation-associated colon cancer in a mouse model

21 January 2018

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Interleukin (IL)-18, a biomarker of human ovarian carcinoma, is predominantly released as biologically inactive precursor

21 January 2018

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Why not treat human cancer with interleukin-1 blockade?

21 January 2018

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Immunomodulatory IL-18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status.

21 January 2018

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IL-18 Induces PD-1-Dependent Immunosuppression in Cancer

21 January 2018

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Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

21 January 2018

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Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist

21 January 2018

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12 December 2020

Contribution of IL-1 to resistance to Streptococcus pneumoniae infection

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12 December 2020

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

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12 December 2020

Characterization of a myxoma virus-encoded serpin-like protein with activity against interleukin-1 beta-converting enzyme

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12 December 2020

Chronic blockade of interleukin-1 (IL-1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury

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12 December 2020

Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1alpha on metastasis and the location of B16F1 melanoma cell arrest

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12 December 2020

IL-1 receptor antagonist anakinra enhances tumour growth inhibition in mice receiving peptide vaccination and beta-(1-3),(1-6)-D-glucan.

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12 December 2020

IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells

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12 December 2020

CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells

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12 December 2020

IL-1RA agonist (anakinra) in the treatment of multifocal castleman disease: case report

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12 December 2020

Caspase-1 enhances the apoptotic response of prostate cancer cells to ionizing radiation.

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12 December 2020

Variations in the interleukin-1 receptor antagonist gene impact on survival of patients with advanced colorectal cancer

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12 December 2020

IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.

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12 December 2020

Loss of caspase-1 and caspase-3 protein expression in human prostate cancer

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12 December 2020

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

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12 December 2020

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

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12 December 2020

Antihyperalgesic effects induced by the IL-1 receptor antagonist anakinra and increased IL-1beta levels in inflamed and osteosarcoma-bearing mice

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12 December 2020

Effect of interleukin 1 receptor antagonist gene transduction on human melanoma xenografts in nude mice

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12 December 2020

Interleukin-1β–Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen–Induced Tumors

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12 December 2020

Decoding cell death signals in inflammation and immunity

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12 December 2020

Identifiers

DOI

10.1038/NI.2224

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26 August 2017

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PubMed ID

22430787