Cell cycle activation and aneuploid neurons in Alzheimer's disease (Q38005023)

26 August 2017

Cell cycle activation and aneuploid neurons in Alzheimer's disease (English)

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26 August 2017

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Thomas Arendt

1

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PubMed ID

22528601

26 August 2017

language of work or name

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13 April 2012

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26 August 2017

Molecular Neurobiology

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26 August 2017

46

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26 August 2017

1

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26 August 2017

125-135

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https://scigraph.springernature.com/pub.10.1007/s12035-012-8262-0

26 August 2017

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Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity

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Constitutive expression of functionally active cyclin-dependent kinases and their binding partners suggests noncanonical functions of cell cycle regulators in differentiated neurons

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Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity

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Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease

21 January 2018

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Senile plaques are located between apical dendritic clusters.

21 January 2018

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Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias

21 January 2018

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Cortical atrophy in senile dementia of the Alzheimer type is mainly due to a decrease in cortical length

21 January 2018

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Some morphometric aspects of the brain in senile dementia of the alzheimer type

21 January 2018

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Minicolumn thinning in temporal lobe association cortex but not primary auditory cortex in normal human ageing

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Disruption of astroglial interlaminar processes in Alzheimer's disease.

21 January 2018

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21 January 2018

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Clustering of Pick bodies in patients with Pick's disease.

21 January 2018

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Modular concepts of brain organization and the neuropathology of psychiatric conditions.

21 January 2018

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Chromosomal variation in neurons of the developing and adult mammalian nervous system

21 January 2018

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Aneuploidy and confined chromosomal mosaicism in the developing human brain.

21 January 2018

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A long, remarkable journey: tangential migration in the telencephalon.

21 January 2018

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Neuronal subtype specification in the cerebral cortex

21 January 2018

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Neuronal migration, with special reference to developing human brain: a review

21 January 2018

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Specification of cerebral cortical areas

21 January 2018

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The columnar organization of the neocortex

21 January 2018

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Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion

21 January 2018

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Nature versus nurture revisited: an old idea with a new twist

21 January 2018

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Changes in cell-cycle kinetics during the development and evolution of primate neocortex

21 January 2018

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Elevated gene expression levels distinguish human from non-human primate brains

21 January 2018

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Intra- and interspecific variation in primate gene expression patterns

21 January 2018

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Induced gene expression in human brain after the split from chimpanzee

21 January 2018

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Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles

21 January 2018

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Regional patterns of gene expression in human and chimpanzee brains

21 January 2018

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A neutral model of transcriptome evolution

21 January 2018

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Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli.

21 January 2018

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Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain

21 January 2018

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Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning

21 January 2018

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Aneuploid neurons are functionally active and integrated into brain circuitry

21 January 2018

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Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease.

21 January 2018

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Constitutional aneuploidy in the normal human brain.

21 January 2018

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Human interphase chromosomes: a review of available molecular cytogenetic technologies.

21 January 2018

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Aneuploid mosaicism in the developing and adult cerebellar cortex

21 January 2018

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Neuronal DNA content variation (DCV) with regional and individual differences in the human brain

21 January 2018

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Tetraploid DNA Content of Purkinje Neurons of Human Cerebellar Cortex

21 January 2018

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Neuronal polyploidy and nuclear volumes in the cat central nervous system.

21 January 2018

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A cytochemical and autoradiographic study of nuclear DNA in mouse Purkinje cells.

21 January 2018

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Are all the neuronal nuclei polyploid?

21 January 2018

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A quantitative cytochemical study of the DNA content of neurons of rat cerebellar cortex

21 January 2018

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DNA content of neurons in the cat hippocampus.

21 January 2018

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Cytophotometric and autoradiographic evidence for post-natal DNA synthesis in neurons of the rat cerebral cortex

21 January 2018

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DNA content of neurons in rat central nervous system

21 January 2018

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Are CNS neurons polyploid? A critical analysis based upon cytophotometric study of the DNA content of cerebellar and olfactory bulbar neurons of the bat.

21 January 2018

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Extra DNA in forebrain cortical neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

DNA content of purified preparations of mouse Purkinje neurons isolated by a velocity sedimentation technique

21 January 2018

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DNA constancy in neurons of the human cerebellum and spinal cord as revealed by Feulgen cytophotometry and cytofluorometry

21 January 2018

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The DNA content of Purkinje cells in mammals.

21 January 2018

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Polyploidy in the human nervous system. 1. The DNA content of neurones and glia of the cerebellum.

21 January 2018

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Optical errors in scanning stage absorbance cytophotometry. I. Procedures for correcting apparent integrated absorbance values for distributional, glare, and diffraction errors.

21 January 2018

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Constancy and variability in the content of DNA in cerebellar Purkinje cell nuclei. A cytophotometric study

21 January 2018

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Cytophotometric re-investigation of DNA content in Purkinje cells of the rat cerebellum.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor

21 January 2018

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Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex.

21 January 2018

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The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study.

21 January 2018

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Multicolor fluorescent in situ hybridization on post-mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseases.

21 January 2018

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Widespread monoallelic expression on human autosomes

21 January 2018

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Evolution of the aging brain transcriptome and synaptic regulation

21 January 2018

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Large-scale copy number polymorphism in the human genome

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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To err (meiotically) is human: the genesis of human aneuploidy

21 January 2018

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Cytogenetics of human brain tumors

21 January 2018

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Chromosome studies in 70 brain tumors with special attention to sex chromosome loss and single autosomal trisomy.

21 January 2018

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Mitotic misregulation and human aging

21 January 2018

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Chromosome studies of patients with Alzheimer disease.

21 January 2018

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Chromosomal abnormality in dementia of Alzheimer type.

21 January 2018

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Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease.

21 January 2018

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Increased aneuploidy in Alzheimer disease

21 January 2018

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Cytogenetic studies of familial and sporadic Alzheimer disease.

21 January 2018

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Rapid detection of human chromosome 21 aberrations by in situ hybridization

21 January 2018

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Analysis of chromosome 21 copy number in uncultured amniocytes by fluorescence in situ hybridization using a cosmid contig

21 January 2018

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Brief report: association of sex chromosome anomalies with childhood-onset psychotic disorders.

21 January 2018

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No evidence of increased risk for schizophrenia or bipolar affective disorder in persons with aneuploidies of the sex chromosomes.

21 January 2018

1 reference

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Karyotype analysis of 161 unrelated schizophrenics: no increased rates of X chromosome mosaicism or inv(9), using ethnically matched and age-stratified controls.

21 January 2018

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Microcephaly is not mandatory for the diagnosis of mosaic variegated aneuploidy syndrome.

21 January 2018

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High risk of malignancy in mosaic variegated aneuploidy syndrome

21 January 2018

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Cancer-prone syndrome of mosaic variegated aneuploidy and total premature chromatid separation: report of five infants

21 January 2018

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Syndrome of microcephaly, Dandy-Walker malformation, and Wilms tumor caused by mosaic variegated aneuploidy with premature centromere division (PCD): report of a new case and review of the literature

21 January 2018

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Child with mosaic variegated aneuploidy and embryonal rhabdomyosarcoma

21 January 2018

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Karyotypes in 90 human gliomas

21 January 2018

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

21 January 2018

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Identification of human brain tumour initiating cells

21 January 2018

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Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons

21 January 2018

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Laser scanning cytometry in human brain slices

21 January 2018

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Selective cell death of hyperploid neurons in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease

21 January 2018

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Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Chromosomal mosaicism goes global

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.

21 January 2018

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Decreased base excision repair and increased helicase activity in Alzheimer's disease brain.

21 January 2018

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DNA repair mechanisms in neurological diseases: facts and hypotheses

21 January 2018

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When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Gender differences and the interpretation of genetic instability in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Mitotic mechanisms in Alzheimer's disease?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

An attempt to influence DNA content in postmitotic Purkinje cells of the cerebellum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Molecular insights into human brain evolution

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Distribution of Human Chromosome Counts in Relation to Age

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8262-0

Brain evolution and Alzheimer's disease

21 January 2018

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12 December 2020

Postnatal development of tetraploid DNA content in rat purkinje cells: a quantitative cytochemical study.

1 reference

12 December 2020

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1 reference

12 December 2020

The deoxyribonucleic acid content of individual rat cell nuclei

1 reference

12 December 2020

Genomic landscape of the Alzheimer's disease brain: chromosome instability--aneuploidy, but not tetraploidy--mediates neurodegeneration.

1 reference

12 December 2020

Clustering of pathological features in Alzheimer's disease: clinical and neuroanatomical aspects.

1 reference

12 December 2020

Chromosome aneuploidy in Alzheimer's disease

1 reference

12 December 2020

The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall

1 reference

12 December 2020

Neurons, astrocytes, and oligodendrocytes of the rat cerebral cortex originate from separate progenitor cells: an ultrastructural analysis of clonally related cells.

1 reference

12 December 2020

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease.

1 reference

12 December 2020

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

1 reference

12 December 2020

Quantitative analysis of DNA in the neurons of the visual cortex of the brain at the early stages of postnatal ontogenesis of guinea pigs.

1 reference

12 December 2020

Cytogenetic findings in 250 schizophrenics: evidence confirming an excess of the X chromosome aneuploidies and pericentric inversion of chromosome 9

1 reference

12 December 2020

The somatic chromosomes in mongolism

1 reference

12 December 2020

Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer's disease brain.

1 reference

12 December 2020

Feulgen-DNA content of the Purkinje neuron: "diploid" or "tetraploid"?

1 reference

12 December 2020

Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death.

1 reference

12 December 2020

The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.

1 reference

12 December 2020

Radial and horizontal deployment of clonally related cells in the primate neocortex: relationship to distinct mitotic lineages

1 reference

12 December 2020

Vulnerability to Alzheimer's pathology in neocortex: the roles of plasticity and columnar organization.

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12 December 2020

Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders

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12 December 2020

Polyploidy of mononuclear and binuclear neurons in the upper cervical ganglia of the rabbit

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12 December 2020

Number of Purkinje cells with an increased DNA content in rat cerebellum

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12 December 2020

Chromosome changes in Alzheimer's presenile dementia

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12 December 2020

Feulgen-DNA and fast-green histone estimations in individual cell nuclei of the cerebellum of young and old rats

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12 December 2020

Enzymology of DNA replication and repair in the brain.

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12 December 2020

Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer's disease.

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12 December 2020

Histones and DNA increase synchronously in neurons during early postnatal development of the rat forebrain cortex

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12 December 2020

Mongolism; a chromosomal disease (trisomy).

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12 December 2020

DNA replication precedes neuronal cell death in Alzheimer's disease.

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12 December 2020

Fluorescence in situ hybridization and comparative genomic hybridization.

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12 December 2020

Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age

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12 December 2020

Identification of a cancer stem cell in human brain tumors

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12 December 2020

Optical errors in scanning stage absorbance cytophotometry. II. Application of correction factors for residual distributional error, glare and diffraction error in practical cytophotometry

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12 December 2020

Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.

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12 December 2020

Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells.

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12 December 2020

Modality and topographic properties of single neurons of cat's somatic sensory cortex

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12 December 2020

[Cytophotometric determination of DNA in nuclei of neurons and glia cells in the cerebral cortex of rats at different stages of ontogenesis]

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12 December 2020

DNA content in the Purkinje cells of the rat cerebellum spontaneously infected with Kilham virus

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12 December 2020

Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders

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12 December 2020

Cytophotometry and its Biological Application

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12 December 2020

Cytophotometric measurement of nucleic acid and protein content of the ganglia cells of rats during postnatal development and in old age

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12 December 2020

Sex chromosome loss and aging: in situ hybridization studies on human interphase nuclei

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12 December 2020

Schizophrenia and sex chromosome anomalies

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12 December 2020

The influence of sex chromosome aneuploidy on brain asymmetry

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12 December 2020

Cytogenetic changes in patients with senile dementia

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12 December 2020

Alteration of gene expression by chromosome loss in the postnatal mouse brain.

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12 December 2020

Basic factors in the polyploidization of cerebellar Purkinfe cells in chick embryogenesis. III. Kinetics of RNA and DNA in Purkinje cell nuclei

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12 December 2020

Chromosomal mosaicisms and occasional acentric chromosomal fragments in schizophrenic patients

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10.1007/S12035-012-8262-0

Identifiers

DOI

1 reference

PubMed ID

22528601

Dimensions Publication ID

26 August 2017

0 references

1 reference

PubMed ID

22528601