Effects of glucocorticoids and exercise on pancreatic β-cell function and diabetes development (Q38007405)

26 August 2017

Effects of glucocorticoids and exercise on pancreatic β-cell function and diabetes development (English)

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26 August 2017

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Jacqueline L Beaudry

1

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PubMed ID

22556149

26 August 2017

Michael C Riddell

series ordinal

2

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26 August 2017

1 October 2012

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Diabetes - Metabolism: Research and Reviews

26 August 2017

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26 August 2017

28

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26 August 2017

560-573

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26 August 2017

7

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Islet architecture: A comparative study

26 August 2017

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Glucocorticoid-induced diabetes and adrenal suppression: how to detect and manage them

21 January 2018

1 reference

Intense exercise has unique effects on both insulin release and its roles in glucoregulation: implications for diabetes

21 January 2018

1 reference

Plasma adiponectin increases postprandially in obese, but not in lean, subjects.

21 January 2018

1 reference

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

21 January 2018

1 reference

Dynamics of insulin sensitivity, -cell function, and -cell mass during the development of diabetes in fa/fa rats.

21 January 2018

1 reference

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

Advancing therapy in type 2 diabetes mellitus with early, comprehensive progression from oral agents to insulin therapy

21 January 2018

1 reference

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

21 January 2018

1 reference

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

21 January 2018

1 reference

Pancreatic beta-cell mass in European subjects with type 2 diabetes

21 January 2018

1 reference

{beta}-Cell mass dynamics and islet cell plasticity in human type 2 diabetes.

21 January 2018

1 reference

Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats.

21 January 2018

1 reference

Five stages of evolving beta-cell dysfunction during progression to diabetes

21 January 2018

1 reference

Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion

21 January 2018

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beta-cell neogenesis during prolonged hyperglycemia in rats

21 January 2018

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Adult human beta-cell neogenesis?

21 January 2018

1 reference

Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance.

21 January 2018

1 reference

Inflexibility in intramuscular triglyceride fractional synthesis distinguishes prediabetes from obesity in humans.

21 January 2018

1 reference

Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy?

21 January 2018

1 reference

beta-cell turnover: its assessment and implications

21 January 2018

1 reference

Mechanisms linking obesity to insulin resistance and type 2 diabetes

21 January 2018

1 reference

Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes

21 January 2018

1 reference

The effects of glucocorticoids on adipose tissue lipid metabolism

21 January 2018

1 reference

Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus

21 January 2018

1 reference

Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index.

21 January 2018

1 reference

Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?

21 January 2018

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Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restriction

21 January 2018

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The diabetogenic effects of glucocorticoids are more pronounced in low- than in high-insulin responders

21 January 2018

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Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids.

21 January 2018

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High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets

21 January 2018

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Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

21 January 2018

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Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats.

21 January 2018

1 reference

A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding

21 January 2018

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Interactive influences of peroxisome proliferator-activated receptor alpha activation and glucocorticoids on pancreatic beta cell compensation in insulin resistance induced by dietary saturated fat in the rat.

21 January 2018

1 reference

Connexin 36 controls synchronization of Ca2+ oscillations and insulin secretion in MIN6 cells.

21 January 2018

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The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets

21 January 2018

1 reference

The effects of dexamethasone on insulin release and biosynthesis are dependent on the dose and duration of treatment

21 January 2018

1 reference

Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets

21 January 2018

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Dexamethasone increases Na+/K+ ATPase activity in insulin secreting cells through SGK1.

21 January 2018

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Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells

21 January 2018

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Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes

21 January 2018

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Sub-chronic stimulation of glucocorticoid receptor impairs and mineralocorticoid receptor protects cytosolic Ca2+ responses to glucose in pancreatic beta-cells

21 January 2018

1 reference

Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes

21 January 2018

1 reference

Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men.

21 January 2018

1 reference

Insulin resistance and impaired beta cell function in rheumatoid arthritis

21 January 2018

1 reference

Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects.

21 January 2018

1 reference

Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial.

21 January 2018

1 reference

Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin.

21 January 2018

1 reference

Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans.

21 January 2018

1 reference

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial

21 January 2018

1 reference

Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells

21 January 2018

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Dissecting the role of glucocorticoids on pancreas development

21 January 2018

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Winged-helix transcription factors and pancreatic development

21 January 2018

1 reference

Glucocorticoids suppress β-cell development and induce hepatic metaplasia in embryonic pancreas

21 January 2018

1 reference

The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy

21 January 2018

1 reference

Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training

21 January 2018

1 reference

Recurrent intermittent restraint delays fed and fasting hyperglycemia and improves glucose return to baseline levels during glucose tolerance tests in the Zucker diabetic fatty rat--role of food intake and corticosterone.

21 January 2018

1 reference

Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and non-volitional exercise

21 January 2018

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Decreased pituitary sensitivity to glucocorticoids in endurance-trained men.

21 January 2018

1 reference

Voluntary exercise impacts on the rat hypothalamic-pituitary-adrenocortical axis mainly at the adrenal level.

21 January 2018

1 reference

Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamster.

21 January 2018

1 reference

Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats

21 January 2018

1 reference

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

21 January 2018

1 reference

Effects of lifestyle intervention in persons at risk for type 2 diabetes mellitus - results from a randomised, controlled trial

21 January 2018

1 reference

The role of physical activity in type 2 diabetes prevention: physiological and practical perspectives

21 January 2018

1 reference

Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats

21 January 2018

1 reference

The effects of physical training on insulin secretion and effectiveness and on glucose metabolism in obesity and type 2 (non-insulin-dependent) diabetes mellitus.

21 January 2018

1 reference

Physical training may enhance beta-cell function in type 2 diabetes.

21 January 2018

1 reference

Effects of nonglucose nutrients on insulin secretion and action in people with pre-diabetes.

21 January 2018

1 reference

Effects of exercise training intensity on pancreatic beta-cell function

21 January 2018

1 reference

Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats

21 January 2018

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Experimental intrauterine growth retardation in the rat causes a reduction of pancreatic B-cell mass, which persists into adulthood

21 January 2018

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Improved lactational nutrition and postnatal growth ameliorates impairment of glucose tolerance by uteroplacental insufficiency in male rat offspring.

21 January 2018

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Intrauterine growth retardation leads to the development of type 2 diabetes in the rat.

21 January 2018

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Role of stress in the pathogenesis of the metabolic syndrome

21 January 2018

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Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell function

21 January 2018

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Long-term AICAR administration and exercise prevents diabetes in ZDF rats

21 January 2018

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Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats

21 January 2018

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

21 January 2018

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Anti-inflammatory cytokines

21 January 2018

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C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

21 January 2018

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Exercise and dexamethasone oppositely modulate beta-cell function and survival via independent pathways in 90% pancreatectomized rats.

21 January 2018

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Estrogen and exercise may enhance beta-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats

21 January 2018

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Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats

21 January 2018

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The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes

21 January 2018

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Dexamethasone Induces Posttranslational Degradation of GLUT2 and Inhibition of Insulin Secretion in Isolated Pancreatic β Cells

21 January 2018

1 reference

Voluntary running exercise prevents β-cell failure in susceptible islets of the Zucker diabetic fatty rat

21 January 2018

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EFFECTS OF CARBOHYDRATES ON SECRETION OF INSULIN FROM ISOLATED RAT PANCREAS

21 January 2018

1 reference

7 January 2021

Dynamics of insulin secretion in obesity and diabetes

1 reference

7 January 2021

The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements

1 reference

7 January 2021

EFFECTS OF CORTISOL IN GUINEA PIGS WITH NORMAL AND ATROPHIC EXOCRINE PANCREAS

1 reference

7 January 2021

Morphofunctional alterations in endocrine pancreas of short- and long-term dexamethasone-treated rats

1 reference

7 January 2021

Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets

1 reference

7 January 2021

Glucose tolerance, insulin sensitivity and β-cell function in patients with rheumatoid arthritis treated with or without low-to-medium dose glucocorticoids

1 reference

7 January 2021

Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity

1 reference

7 January 2021

Effects of exercise training on skeletal muscle glucose uptake and transport

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7 January 2021

Effect of exercise on insulin action in human skeletal muscle

1 reference

7 January 2021

The effect of physical training on insulin secretion of rat pancreatic islets

1 reference

7 January 2021

Pancreatic islet insulin secretion is increased after resistance exercise in rats

1 reference

7 January 2021

Identifiers

DOI

10.1002/DMRR.2310

1 reference

26 August 2017

1 reference

PubMed ID

22556149