Pharmacogenomics of osteoporosis: a pathway approach. (Q38010749)

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1 February 2020

title

Pharmacogenomics of osteoporosis: a pathway approach (English)

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2

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1 February 2020

author name string

José A Riancho

series ordinal

1

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publication date

1 May 2012

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1 February 2020

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volume

13

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issue

7

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page(s)

815-829

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An estimate of the worldwide prevalence and disability associated with osteoporotic fractures

1 February 2020

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Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling

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Biochemical and molecular mechanisms of action of bisphosphonates.

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Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability

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Raloxifene: mechanism of action, effects on bone tissue, and applicability in clinical traumatology practice

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Bazedoxifene: a review of its use in the treatment of postmenopausal osteoporosis

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Osteoblasts play key roles in the mechanisms of action of strontium ranelate

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Strontium ranelate decreases receptor activator of nuclear factor-ΚB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor

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Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

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Teriparatide (biosynthetic human parathyroid hormone 1-34): a new paradigm in the treatment of osteoporosis

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Parathyroid hormone, its fragments and their analogs for the treatment of osteoporosis

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Teriparatide (1-34 human PTH) regulation of osterix during fracture repair

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New understanding and treatments for osteoporosis

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Role of aromatase in sex steroid action

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Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management

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Association of the aromatase gene alleles with BMD: epidemiological and functional evidence.

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Polymorphisms in the CYP19 gene that influence bone mineral density

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Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women

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Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein

21 January 2018

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Estrogen receptor alpha and beta polymorphisms: is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy?

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The bone mass density in postmenopausal women using hormonal replacement therapy in relation to polymorphism in vitamin D receptor and estrogen receptor genes

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Lack of association between oestrogen receptor polymorphisms and change in bone mineral density with tamoxifen therapy.

21 January 2018

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XbaI polymorphism of the estrogen receptor alpha gene influences the effect of raloxifene on the endothelial function

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A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

21 January 2018

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Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors

21 January 2018

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Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis

21 January 2018

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Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors

21 January 2018

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Association of estrogen receptor-alpha gene Pvull polymorphisms with the effect of calcium supplementation on skeletal development in Chinese pubertal girls

21 January 2018

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Denosumab for prevention of fractures in postmenopausal women with osteoporosis

21 January 2018

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Update on Wnt signaling in bone cell biology and bone disease.

21 January 2018

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Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

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LRP5 mutations in osteoporosis-pseudoglioma syndrome and high-bone-mass disorders

21 January 2018

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High-bone-mass disease and LRP5.

21 January 2018

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

21 January 2018

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

21 January 2018

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Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

21 January 2018

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LRP5 Polymorphisms and response to risedronate treatment in osteoporotic men.

21 January 2018

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Association between Wnt signaling pathway gene polymorphisms and bone response to hormone therapy in postmenopausal Korean women.

21 January 2018

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Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation.

21 January 2018

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BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

21 January 2018

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Wnt signaling in bone metabolism

21 January 2018

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A SNP in steroid receptor coactivator-1 disrupts a GSK3β phosphorylation site and is associated with altered tamoxifen response in bone

21 January 2018

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

21 January 2018

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Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case-control studies.

21 January 2018

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Variants of the serotonin transporter gene, selective serotonin reuptake inhibitors, and bone mineral density in risperidone-treated boys: a reanalysis of data from a cross-sectional study with emphasis on pharmacogenetics

21 January 2018

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Prediction of bone density from vitamin D receptor alleles

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Genome-wide association study of circulating vitamin D levels

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Calcium and vitamin D.

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Does vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization?

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Vitamin D receptor gene polymorphisms modulate the skeletal response to vitamin D supplementation in healthy girls

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BsmI vitamin D receptor genotypes influence the efficacy of antiresorptive treatments in postmenopausal osteoporotic women. A 1-year multicenter, randomized and controlled trial

21 January 2018

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Vitamin D receptor genotypes and response to zoledronic acid therapy in thalassemia-induced osteoporosis

21 January 2018

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Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women

21 January 2018

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Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis

21 January 2018

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Vascular endothelial growth factor genetic polymorphisms and haplotypes in female patients with bisphosphonate-related osteonecrosis of the jaws.

21 January 2018

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A peroxisome proliferator-activated receptor gamma (PPARG) polymorphism is associated with zoledronic acid-related osteonecrosis of the jaw in multiple myeloma patients: analysis by DMET microarray profiling.

21 January 2018

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Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw.

21 January 2018

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Multiple genetic loci for bone mineral density and fractures

21 January 2018

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New sequence variants associated with bone mineral density

21 January 2018

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Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.

21 January 2018

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Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk

21 January 2018

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A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.

21 January 2018

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Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women

21 January 2018

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Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups

21 January 2018

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Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis

21 January 2018

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Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

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Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies.

21 January 2018

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An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits

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Association analyses of 47,500 individuals identifies six fracture loci and 82 BMD loci clustering in biological pathways that regulate osteoblast and osteoclast activity

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Genetic predisposition for the development of ONJ

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Identifiers

DOI

10.2217/PGS.12.50

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22594513%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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