Apixaban: a novel oral inhibitor of factor Xa. (Q38020739)

27 August 2017

title

Apixaban: a novel oral inhibitor of factor Xa. (English)

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27 August 2017

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Edith Nutescu

1

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27 August 2017

publication date

1 July 2012

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American Journal of Health-System Pharmacy

27 August 2017

published in

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27 August 2017

volume

69

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27 August 2017

issue

13

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27 August 2017

page(s)

1113-1126

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The Worcester Venous Thromboembolism study: a population-based study of the clinical epidemiology of venous thromboembolism

27 August 2017

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New oral anticoagulants in development

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The new oral anticoagulants

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Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood [...]

31 March 2020

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Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro.

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Apixaban metabolism and pharmacokinetics after oral administration to humans

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Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.

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In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies

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Quantification of apixaban's therapeutic utility in prevention of venous thromboembolism: selection of phase III trial dose

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Apixaban or enoxaparin for thromboprophylaxis after knee replacement

31 March 2020

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Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial

31 March 2020

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Apixaban versus enoxaparin for thromboprophylaxis after hip replacement

31 March 2020

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Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial

31 March 2020

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Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients

31 March 2020

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Apixaban versus warfarin in patients with atrial fibrillation

31 March 2020

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31 March 2020

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Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study

31 March 2020

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Aspirin: promise and resistance in the new millennium

31 March 2020

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31 March 2020

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Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment

31 March 2020

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Apixaban in patients with atrial fibrillation

31 March 2020

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Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Effect of apixaban, an oral and direct factor Xa inhibitor, on coagulation activity biomarkers following acute coronary syndrome

31 March 2020

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Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor--after multiple dosing in healthy male subjects

31 March 2020

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Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects

31 March 2020

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The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

31 March 2020

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31 March 2020

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Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans

31 March 2020

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Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development

31 March 2020

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Dabigatran versus warfarin in patients with atrial fibrillation

31 March 2020

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Rivaroxaban versus warfarin in nonvalvular atrial fibrillation

31 March 2020

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Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial

31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Rivaroxaban vs dabigatran for thromboprophylaxis after joint-replacement surgery: exploratory indirect comparison based on meta-analysis of pivotal clinical trials

31 March 2020

1 reference

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Enoxaparin versus dabigatran or rivaroxaban for thromboprophylaxis after hip or knee arthroplasty: Results of separate pooled analyses of phase III multicenter randomized trials

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Efficacy and safety of dabigatran etexilate for the prevention of venous thromboembolism following total hip or knee arthroplasty. A meta-analysis.

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP110418

Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study

31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a randomized trial

31 March 2020

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Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial

31 March 2020

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Dabigatran versus warfarin in the treatment of acute venous thromboembolism

31 March 2020

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Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial

31 March 2020

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31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial.

31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

Rationale and design of the Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome-thrombolysis in myocardial infarction 51 (ATLAS-ACS 2 TIMI 51) trial: a randomized, double-blind, pla

31 March 2020

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Treatment of Proximal Deep-Vein Thrombosis With the Oral Direct Factor Xa Inhibitor Rivaroxaban (BAY 59-7939): The ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) Study

31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study

31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

Oral rivaroxaban for symptomatic venous thromboembolism

31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol

31 March 2020

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https://api.crossref.org/works/10.2146%2FAJHP110418

31 March 2020

Identifiers

DOI

10.2146/AJHP110418

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27 August 2017

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