Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver. (Q38023300)

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6 February 2020

title

Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver (English)

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6 February 2020

1

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6 February 2020

author name string

Chiara Degirolamo

series ordinal

2

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6 February 2020

Antonio Moschetta

series ordinal

3

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6 February 2020

language of work or name

English

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publication date

1 December 2012

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6 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22753116%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

56

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6 February 2020

issue

6

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6 February 2020

page(s)

2404-2411

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Evolution of the Fgf and Fgfr gene families

6 February 2020

cites work

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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Liver-specific activities of FGF19 require Klotho beta

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

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FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action

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High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

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FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption

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A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

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Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

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Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling

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FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

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Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).

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Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism

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Identification of a novel FGF, FGF-21, preferentially expressed in the liver

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

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PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis

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Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha.

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Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

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Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.

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Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes

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Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

21 January 2018

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betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

21 January 2018

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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

21 January 2018

1 reference

Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling

21 January 2018

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Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo

21 January 2018

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FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

21 January 2018

1 reference

Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.

21 January 2018

1 reference

Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis

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Fibroblast growth factor 21 corrects obesity in mice

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The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes

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Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

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Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers.

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Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans.

21 January 2018

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Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.

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The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

21 January 2018

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Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity.

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Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease

21 January 2018

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

21 January 2018

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FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

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Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

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