How can high-throughput screening deliver drugs to treat atherosclerosis? (Q38028514)

27 August 2017

How can high-throughput screening deliver drugs to treat atherosclerosis? (English)

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27 August 2017

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1 reference

Yuan Yang

1

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27 August 2017

Li Wang

series ordinal

2

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27 August 2017

Shuyi Si

series ordinal

3

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27 August 2017

Bin Hong

series ordinal

4

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27 August 2017

language of work or name

English

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publication date

1 December 2010

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Expert Opinion on Drug Discovery

27 August 2017

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27 August 2017

5

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27 August 2017

12

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27 August 2017

1175-1188

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Advancing therapy for hypercholesterolemia

27 August 2017

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https://api.crossref.org/works/10.1517%2F17460441.2010.529896

The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Future therapeutic directions in reverse cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Atherosclerosis: the new view

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

The assembly and secretion of apolipoprotein B-containing lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Scavenger receptors and oxidized low density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Development of a radiometric spot-wash assay for squalene synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

SCAP ligands are potent new lipid-lowering drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Berberine-induced LDLR up-regulation involves JNK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Traditional chinese medicine in treatment of metabolic syndrome

21 January 2018

1 reference

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Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

The discovery of ezetimibe: a view from outside the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Microsomal triglyceride transfer protein: a multifunctional protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

An unbiased chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Discovery of antagonists for human scavenger receptor CD36 via an ELISA-like high-throughput screening assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Identification of two antagonists of the scavenger receptor CD36 using a high-throughput screening model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Identification of upregulators of human ATP-binding cassette transporter A1 via high-throughput screening of a synthetic and natural compound library

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Transcriptional regulatory networks in lipid metabolism control ABCA1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.

21 January 2018

1 reference

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N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Miniaturization of cell-based beta-lactamase-dependent FRET assays to ultra-high throughput formats to identify agonists of human liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Mechanism of action of fibrates on lipid and lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Potent and selective PPAR-alpha agonist LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels on a background of atorvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Effects of torcetrapib in patients at high risk for coronary events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Effect of torcetrapib on the progression of coronary atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

The pharmacology and off-target effects of some cholesterol ester transfer protein inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Antiatherogenic functionality of high density lipoprotein: how much versus how good

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform

21 January 2018

1 reference

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Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer pro

21 January 2018

1 reference

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A high-precision fluorogenic cholesteryl ester transfer protein assay compatible with animal serum and 3456-well assay technology.

21 January 2018

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2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Dose-Dependent Acceleration of High-Density Lipoprotein Catabolism by Endothelial Lipase

21 January 2018

1 reference

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Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.529896

Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis

21 January 2018

1 reference

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A high-throughput screen for endothelial lipase using HDL as substrate

21 January 2018

1 reference

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Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors

21 January 2018

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Identification of scavenger receptor SR-BI as a high density lipoprotein receptor

21 January 2018

1 reference

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The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution

21 January 2018

1 reference

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Structure and localization of the human gene encoding SR-BI/CLA-1. Evidence for transcriptional control by steroidogenic factor 1.

21 January 2018

1 reference

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The HDL receptor SR-BI: a new therapeutic target for atherosclerosis?

21 January 2018

1 reference

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Identification of novel human high-density lipoprotein receptor Up-regulators using a cell-based high-throughput screening assay

21 January 2018

1 reference

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Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells

21 January 2018

1 reference

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The statins in preventive cardiology.

21 January 2018

1 reference

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High-throughput screening: update on practices and success

21 January 2018

1 reference

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Natural products as sources of new drugs over the last 25 years

21 January 2018

1 reference

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10.1517/17460441.2010.529896

21 January 2018

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DOI

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release_zddqaecb7jcbxek6meodv6huxu

27 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/zddqaecb7jcbxek6meodv6huxu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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