Lipophilicity in drug discovery (Q38028532)

27 August 2017

Lipophilicity in drug discovery (English)

1 reference

27 August 2017

1 reference

Michael J Waring

1

1 reference

PubMed ID

22823020

27 August 2017

language of work or name

English

0 references

publication date

1 March 2010

1 reference

Expert Opinion on Drug Discovery

27 August 2017

1 reference

27 August 2017

5

1 reference

27 August 2017

3

1 reference

27 August 2017

235-248

1 reference

Zur Theorie der Alkoholnarkose

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Accurate In Silico log PPredictions: One Can't Embrace the Unembraceable

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

logD7.4 modeling using Bayesian Regularized Neural Networks. Assessment and correction of the errors of prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Solubility and partitioning I: Solubility of nonelectrolytes in water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Prediction of aqueous solubility of organic compounds by the general solubility equation (GSE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

A consistent dataset of kinetic solubilities for early-phase drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

QSAR model for drug human oral bioavailability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Property-based design: optimization of drug absorption and pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Baseline lipophilicity relationships in human cytochromes P450 associated with drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Substrate SARs in human P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Using the Golden Triangle to optimize clearance and oral absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

21 January 2018

A bioavailability score.

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Prediction of intestinal first-pass effect of phenacetin in the rat from enzyme kinetic data--correlation with in vivo data using mucosal blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Fast gradient HPLC method to determine compounds binding to human serum albumin. Relationships with octanol/water and immobilized artificial membrane lipophilicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Do enthalpy and entropy distinguish first in class from best in class?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Physiochemical drug properties associated with in vivo toxicological outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

A quantitative assessment of hERG liability as a function of lipophilicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Medicinal chemistry of hERG optimizations: Highlights and hang-ups

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Global mapping of pharmacological space

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

A comparison of physiochemical property profiles of development and marketed oral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Why drugs fail--a study on side effects in new chemical entities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Ligand efficiency: a useful metric for lead selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Escape from flatland: increasing saturation as an approach to improving clinical success.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

Percutaneous absorption: a multiple pathway model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003605098

10.1517/17460441003605098

21 January 2018

Identifiers

DOI

1 reference

release_vlf7q5qzkvaunhj2l7kiqb2ngq

27 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vlf7q5qzkvaunhj2l7kiqb2ngq

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

22823020

1 reference

PubMed ID

22823020