Practical metabolomics in drug discovery (Q38028533)

27 August 2017

Practical metabolomics in drug discovery (English)

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27 August 2017

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Keith M Wilcoxen

1

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27 August 2017

Taisuke Uehara

2

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27 August 2017

Khin Than Myint

3

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27 August 2017

Yoshiaki Sato

4

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27 August 2017

Yoshiya Oda

5

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27 August 2017

language of work or name

English

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publication date

1 March 2010

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Expert Opinion on Drug Discovery

27 August 2017

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27 August 2017

5

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27 August 2017

3

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27 August 2017

249-263

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A network view of disease and compound screening

27 August 2017

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https://api.crossref.org/works/10.1517%2F17460441003631854

Metabolomics in systems biology

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

HMDB: a knowledgebase for the human metabolome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Mass spectrometry-based metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Cyclosporin A-induced changes in endogenous metabolites in rat urine: a metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Utility of separation science in metabolomic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

UPLC-MS-based analysis of human plasma for metabonomics using solvent precipitation or solid phase extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

The emerging field of lipidomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Analytical strategies in lipidomics and applications in disease biomarker discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Lipid-based biomarkers for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

21 January 2018

1 reference

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Development of a reverse-phase liquid chromatography electrospray ionization mass spectrometry method for lipidomics, improving detection of phosphatidic acid and phosphatidylserine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Brain phosphoinositide extraction, fractionation, and analysis by MALDI-TOF MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis

21 January 2018

1 reference

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Imaging mass spectrometry: a new tool for the analysis of skin biopsy. Application in Fabry's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Mass spectrometry: from proteomics to metabolomics and lipidomics

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Standardizing GC-MS metabolomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Quantitative profiling of polar cationic metabolites in human cerebrospinal fluid by reversed-phase nanoliquid chromatography/mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Polar anionic metabolome analysis by nano-LC/MS with a metal chelating agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: when does ESI turn into nano-ESI?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Charge competition and the linear dynamic range of detection in electrospray ionization mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

High Resolution Separations and Improved Ion Production and Transmission in Metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Analysis of highly polar compounds of plant origin: combination of hydrophilic interaction chromatography and electrospray ion trap mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Quantitative phosphorus metabolomics using nanoflow liquid chromatography-tandem mass spectrometry and culture-derived comprehensive global internal standards

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Focused lipidomics by tandem mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

A shotgun tandem mass spectrometric analysis of phospholipids with normal-phase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Lipidomics: an analysis of cellular lipids by ESI-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Fully automated chip-based mass spectrometry for complex carbohydrate system analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Basic analytical systems for lipidomics by mass spectrometry in Japan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Novel application of reversed-phase UPLC-oaTOF-MS for lipid analysis in complex biological mixtures: a new tool for lipidomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Profiling of human urinary phospholipids by nanoflow liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Quantitative profiling of phosphatidylcholine and phosphatidylethanolamine in a steatosis/fibrosis model of rat liver by nanoflow liquid chromatography/tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Shotgun analysis of phospholipids from mouse liver and brain by nanoflow liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Method for lipidomic analysis: p53 expression modulation of sulfatide, ganglioside, and phospholipid composition of U87 MG glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Nanoflow liquid chromatography-tandem mass spectrometry for the characterization of intact phosphatidylcholines from soybean, bovine brain, and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Data processing for mass spectrometry-based metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

MathDAMP: a package for differential analysis of metabolite profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

MeltDB: a software platform for the analysis and integration of metabolomics experiment data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

MetaboAnalyst: a web server for metabolomic data analysis and interpretation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Emerging bioinformatics for the metabolome

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Plant metabolomics: large-scale phytochemistry in the functional genomics era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Singular value decomposition for genome-wide expression data processing and modeling

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Cluster analysis and display of genome-wide expression patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

A bioinformatic approach to the identification of candidate genes for the development of new cancer diagnostics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

How to avoid over-fitting in multivariate calibration--the conventional validation approach and an alternative.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Metabolomic database annotations via query of elemental compositions: mass accuracy is insufficient even at less than 1 ppm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

The KEGG databases at GenomeNet

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

KEGG Atlas mapping for global analysis of metabolic pathways

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Applications of metabolomics in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Metabonomics in toxicology: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Metabolomics for assessment of nutritional status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

21 January 2018

Metabolomics of cancer

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Alzheimer's disease beyond the genomic era: nuclear magnetic resonance (NMR) spectroscopy-based metabolomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Metabolomics tools for identifying biomarkers for neuropsychiatric diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Application of metabolomics to cardiovascular biomarker and pathway discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

21 January 2018

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Reactome array: forging a link between metabolome and genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

The human cerebrospinal fluid metabolome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003631854

Urinary Lipid Profiling for the Identification of Fabry Hemizygotes and Heterozygotes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003631854

Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy

21 January 2018

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Cross-platform comparison of methods for quantitative metabolomics of primary metabolism

21 January 2018

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24 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1021/AC8022857

Identifiers

DOI

10.1517/17460441003631854

1 reference

27 August 2017

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