Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies (Q38029728)

27 August 2017

Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies (English)

1 reference

27 August 2017

Berina Eppink

1

1 reference

27 August 2017

Przemek M Krawczyk

series ordinal

2

1 reference

27 August 2017

Jan Stap

series ordinal

3

1 reference

27 August 2017

Roland Kanaar

series ordinal

4

1 reference

27 August 2017

26 July 2012

1 reference

International Journal of Hyperthermia

27 August 2017

1 reference

27 August 2017

28

1 reference

27 August 2017

6

1 reference

27 August 2017

509-517

1 reference

Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells.

27 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Alkylation damage in DNA and RNA--repair mechanisms and medical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

DNA repair helicases as targets for anti-cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

DNA intercalators in cancer therapy: organic and inorganic drugs and their spectroscopic tools of analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

The endless tale of non-homologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Role of Artemis in DSB repair and guarding chromosomal stability following exposure to ionizing radiation at different stages of cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Non-homologous end-joining, a sticky affair

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Rad51 accumulation at sites of DNA damage and in postreplicative chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

The importance of repairing stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Multiple interlinked mechanisms to circumvent DNA replication roadblocks

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Initiation of genetic recombination and recombination-dependent replication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

DNA double-strand break repair: all's well that ends well

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Homologous recombination: down to the wire

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Delaying S-phase progression rescues cells from heat-induced S-phase hypertoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Effects of heat shock on the Mre11/Rad50/Nbs1 complex in irradiated or unirradiated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

ATP-dependent and independent functions of Rad54 in genome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

The non-homologous end-joining pathway is not involved in the radiosensitization of mammalian cells by heat shock

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Thermal radiosensitization in heat- and radiation-sensitive mutants of CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Thermal radiosensitization in two pairs of CHO wild-type and radiation-sensitive mutant cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Selective targeting of homologous DNA recombination repair by gemcitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Radiosensitization by hyperthermia in the chicken B-lymphocyte cell line DT40 and its derivatives lacking nonhomologous end joining and/or homologous recombination pathways of DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Evaluation of recombination repair pathways in thermal radiosensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Transfection of human tumour cells with Mre11 siRNA and the increase in radiation sensitivity and the reduction in heat-induced radiosensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

The RAD51 gene family, genetic instability and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Induction of linear tracks of DNA double-strand breaks by alpha-particle irradiation of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Cell biological effects of hyperthermia alone or combined with radiation or drugs: a short introduction to newcomers in the field.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Heat shock proteins: stress proteins with Janus-like properties in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Phosphotyrosine confers client specificity to Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Understanding of the Hsp90 molecular chaperone reaches new heights.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

21 January 2018

Heat shock protein 90.

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Heat shock proteins in breast cancer progression--a suitable case for treatment?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Implication of heat shock protein 90 (HSP90) in tumor angiogenesis: a molecular target for anti-angiogenic therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Targeting the dynamic HSP90 complex in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hsp90 molecular chaperone inhibitors: are we there yet?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hsp90: a novel target for the disruption of multiple signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

HSP90 and the chaperoning of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Inhibition of hsp90 compromises the DNA damage response to radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hsp90 regulates the Fanconi anemia DNA damage response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Cervical cancer: radiotherapy and hyperthermia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Targeting HSP70-induced thermotolerance for design of thermal sensitizers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

A randomised phase II study on neo-adjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hyperthermia dose-effect relationship in 420 patients with cervical cancer treated with combined radiotherapy and hyperthermia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Radiochemotherapy for bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hyperthermia adds to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hyperthermia in combined treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Hyperthermia: a potent enhancer of radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F02656736.2012.695427

10.3109/02656736.2012.695427

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference