Molecular functions of metallothionein and its role in hematological malignancies (Q38030059)

27 August 2017

3 references

26 October 2020

20 December 2020

3 October 2022

Molecular functions of metallothionein and its role in hematological malignancies (English)

1 reference

tumor of hematopoietic and lymphoid tissues

27 August 2017

1 reference

17 December 2019

2 references

22 July 2020

3 October 2022

antineoplastic resistance

1 reference

26 October 2020

2 references

PubMed publication ID

20 December 2020

1

0 references

language of work or name

1 reference

27 July 2012

7 references

Journal of Hematology & Oncology

27 August 2017

3 April 2019

17 December 2019

22 July 2020

26 October 2020

20 December 2020

3 October 2022

7 references

27 August 2017

3 April 2019

17 December 2019

22 July 2020

26 October 2020

20 December 2020

3 October 2022

5

1 reference

27 August 2017

41

1 reference

Creative Commons Attribution 2.0 Generic

27 August 2017

6 references

3 April 2019

17 December 2019

22 July 2020

26 October 2020

20 December 2020

on focus list of Wikimedia project

3 October 2022

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Current findings for recurring mutations in acute myeloid leukemia

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Prognostic classification of patients with acute lymphoblastic leukemia by using gene copy number profiles identified from array-based comparative genomic hybridization data

6 September 2017

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Metallothionein-1 isoforms and vimentin are direct PU.1 downstream target genes in leukemia cells

6 September 2017

1 reference

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The role of metallothionein in oncogenesis and cancer prognosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Pathobiology of classical Hodgkin lymphoma.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein expression in human neoplasia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothioneins in human tumors and potential roles in carcinogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Differential expression of metallothionein 1 and 2 isoforms in breast cancer lines with different invasive potential: identification of a novel nonsilent metallothionein-1H mutant variant.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein: A Multifunctional Protein from Toxicity to Cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

A distinct role for apoptosis in the changes in lymphopoiesis and myelopoiesis created by deficiencies in zinc

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Influence of metallothionein-1 localization on its function

6 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

6 September 2017

12 December 2020

Prognostic evaluation of metallothionein expression in human colorectal neoplasms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metal ions as regulators of the conformation and function of the tumour suppressor protein p53: implications for carcinogenesis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein in radiation exposure: its induction and protective role

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Regulatory role of metallothionein in NF-kappaB activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Inhibitory sites in enzymes: zinc removal and reactivation by thionein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein and apoptosis in primary human hepatocellular carcinoma and metastatic adenocarcinoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Cell cycle regulation of metallothionein in human colonic cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Regulation, Linkage, and Sequence of Mouse Metallothionein I and II Genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Cell specificity and an effect of ras on human metallothionein gene expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein and the trace minerals

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblasts

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Zinc transfer from transcription factor IIIA fingers to thionein clusters

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Role of metallothionein in differentiation of leukemia cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Erythropoietin-Induced Metallothionein Gene Expression: Role in Proliferation of K562 Cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein Is a Potential Negative Regulator of Apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein expression prevents apoptosis: a study with antisense phosphorothioate oligodeoxynucleotides in a human T cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein accretion in human hepatic cells is linked to cellular proliferation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Oxygen free radicals and metallothionein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Role of metallothionein in carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein null cells have increased sensitivity to anticancer drugs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Detailed analysis of FLT3 expression levels in acute myeloid leukemia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Expression of metallothionein (MT) and gluthatione s-transferase pi (SGTP) in the bone marrow of patients with myeloproliferative disorders (MPD).

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein and apoptosis in primary human hepatocellular carcinoma (HCC) from northern China.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Enhanced apoptosis in metallothionein null cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein in physiological and physiopathological processes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Cadmium induces apoptosis in a human T cell line

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

DNA radiation damage and its modification by metallothionein

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Regulation of human metallothionein (MT) genes. Differential expression of MTI-F, MTI-G, and MTII-A genes in the hepatoblastoma cell line (HepG2).

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Differential quantitative zinc-induced expression of human metallothionein isogenes in haematopoietic precursor cell lines

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Metallothionein as a useful marker in Hodgkin lymphoma subclassification.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Role of metallothionein as a protective factor against radiation carcinogenesis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Induction of astrocyte metallothioneins (MTs) by zinc confers resistance against the acute cytotoxic effects of methylmercury on cell swelling, Na+ uptake, and K+ release

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Multiple resistance mechanisms in acute nonlymphoblastic leukemia (ANLL).

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3419633

Prognostic significance of metallothionein in B-cell lymphomas

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1756-8722-5-41

Reversible zinc exchange between metallothionein and the estrogen receptor zinc finger

21 January 2018

1 reference

12 December 2020

Characterization of Metallothionein-I-Transgenic Mice

1 reference

12 December 2020

Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias

1 reference

12 December 2020

Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro

1 reference

12 December 2020

Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine

1 reference

12 December 2020

Localization of metallothionein in nuclei of growing primary cultured adult rat hepatocytes

1 reference

12 December 2020

Markers of chemoresistance in ovarian carcinomas: an immunohistochemical study of 86 cases

1 reference

12 December 2020

Zinc metabolism and metallothionein expression in bone marrow during erythropoiesis

1 reference

12 December 2020

Metallothionein expression prevents apoptosis. II: Evaluation of the role of metallothionein expression on the chemotherapy-induced apoptosis during the treatment of acute leukemia

1 reference

12 December 2020

Nucleophilic distribution of metallothionein in human tumor cells

1 reference

12 December 2020

Metallothionein: a potential marker for differentiating benign and neoplastic gastrointestinal lymphoid infiltrates

1 reference

12 December 2020

Expression of metallothionein in initial and relapsed childhood acute lymphoblastic leukemia

1 reference

12 December 2020

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

1 reference

12 December 2020

Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation

1 reference

12 December 2020

Downregulated expression of metallothionein and its clinicopathological significance in hepatocellular carcinoma

1 reference

12 December 2020

Prognostic significance of PU.1 in follicular lymphoma

1 reference

12 December 2020

Metallothionein in human immunomagnetically selected CD34+haematopoietic progenitor cells

1 reference

12 December 2020

Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency

1 reference

12 December 2020

Identifiers

DOI

10.1186/1756-8722-5-41

1 reference

PMC publication ID

3419633

Dimensions Publication ID

27 August 2017

0 references

1 reference

PMC publication ID

3419633

27 August 2017

PubMed publication ID

22839501

1 reference

PMC publication ID

3419633