The implications of viral reservoirs on the elite control of HIV-1 infection (Q38032153)

27 August 2017

title

The implications of viral reservoirs on the elite control of HIV-1 infection (English)

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27 August 2017

Robert W Buckheit

1

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27 August 2017

Maria Salgado

series ordinal

2

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27 August 2017

Karen O Martins

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3

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27 August 2017

Joel N Blankson

series ordinal

4

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27 August 2017

publication date

4 August 2012

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Cellular and Molecular Life Sciences

27 August 2017

published in

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27 August 2017

volume

70

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27 August 2017

issue

6

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27 August 2017

page(s)

1009-1019

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Epidemiology and clinical characteristics of elite controllers

27 August 2017

cites work

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HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

21 January 2018

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HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles

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Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

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HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

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Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication

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Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy

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Antibody-dependent cellular cytotoxicity against primary HIV-infected CD4+ T cells is directly associated with the magnitude of surface IgG binding

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CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21

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21 January 2018

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CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors

21 January 2018

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Unstimulated Primary CD4 + T Cells from HIV-1-Positive Elite Suppressors Are Fully Susceptible to HIV-1 Entry and Productive Infection

21 January 2018

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Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by a two-amino-acid insertion in HIV-1 Vif from a nonprogressing mother and child

21 January 2018

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Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection

21 January 2018

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Entire genome of a strain of human immunodeficiency virus type 1 with a deletion of nef that was recovered 20 years after primary infection: large pool of proviruses with deletions of env.

21 January 2018

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

21 January 2018

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Characterization of gag and pol sequences from long-term survivors of human immunodeficiency virus type 1 infection

21 January 2018

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

21 January 2018

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

21 January 2018

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HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition

21 January 2018

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The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

21 January 2018

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Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.

21 January 2018

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Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor

21 January 2018

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Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

21 January 2018

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Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses

21 January 2018

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Impaired replication capacity of acute/early viruses in persons who become HIV controllers

21 January 2018

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Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes

21 January 2018

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Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations

21 January 2018

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Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors

21 January 2018

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21 January 2018

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HIV evolution: CTL escape mutation and reversion after transmission

21 January 2018

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Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

21 January 2018

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Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.

21 January 2018

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Comprehensive analysis of unique cases with extraordinary control over HIV replication

21 January 2018

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Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy

21 January 2018

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Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection

21 January 2018

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Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters

21 January 2018

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A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy

21 January 2018

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Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells

21 January 2018

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Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy

21 January 2018

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HIV-1 continues to replicate and evolve in patients with natural control of HIV infection

21 January 2018

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Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus

21 January 2018

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Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors

21 January 2018

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Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy

21 January 2018

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Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors

21 January 2018

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Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication

21 January 2018

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Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

21 January 2018

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Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics

21 January 2018

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Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor

21 January 2018

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Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy

21 January 2018

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CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load

21 January 2018

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T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors

21 January 2018

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Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study

21 January 2018

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Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape.

21 January 2018

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Spontaneous control of viral replication during primary HIV infection: when is "HIV controller" status established?

21 January 2018

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12 December 2020

High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.

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12 December 2020

Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals

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12 December 2020

Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual

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12 December 2020

HIV-1 Gag evolution in recently infected human leukocyte antigen-B*57 patients with low-level viremia.

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12 December 2020

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

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12 December 2020

Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection

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12 December 2020

Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)

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12 December 2020

Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

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12 December 2020

10.1007/S00018-012-1101-7

Identifiers

DOI

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27 August 2017

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