Plasma biomarkers for Alzheimer's disease: much needed but tough to find (Q38037157)

27 August 2017

Plasma biomarkers for Alzheimer's disease: much needed but tough to find (English)

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27 August 2017

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Simon Lovestone

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author name string

Chantal Bazenet

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1

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27 August 2017

1 August 2012

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27 August 2017

Biomarkers in Medicine

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27 August 2017

6

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27 August 2017

4

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27 August 2017

441-454

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2012 Alzheimer's disease facts and figures

27 August 2017

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Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer-type dementia: implications for trial design

21 January 2018

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Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

21 January 2018

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Biomarkers for Alzheimer's disease and other forms of dementia: clinical needs, limitations and future aspects

21 January 2018

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Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease

21 January 2018

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Biomarkers for Alzheimer's disease therapeutic trials

21 January 2018

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Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset

21 January 2018

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Clinical trial methodologies for disease-modifying therapeutic approaches

21 January 2018

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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

21 January 2018

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Are biomarkers harmful to recruitment and retention in Alzheimer's disease clinical trials? An international perspective.

21 January 2018

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Biological markers of amyloid beta-related mechanisms in Alzheimer's disease

21 January 2018

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Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview.

21 January 2018

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Total and phosphorylated tau protein as biological markers of Alzheimer's disease

21 January 2018

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Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

21 January 2018

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Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease.

21 January 2018

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Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease

21 January 2018

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21 January 2018

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Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease

21 January 2018

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Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants

21 January 2018

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Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease

21 January 2018

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Plasma levels of amyloid beta-protein 42 are increased in women with mild cognitive impairment.

21 January 2018

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Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.

21 January 2018

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Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study

21 January 2018

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A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease

21 January 2018

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Proteomic research in psychiatry

21 January 2018

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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

21 January 2018

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A serum protein-based algorithm for the detection of Alzheimer disease

21 January 2018

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A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI

21 January 2018

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A blood-based algorithm for the detection of Alzheimer's disease

21 January 2018

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Proteome-based plasma biomarkers for Alzheimer's disease

21 January 2018

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Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma.

21 January 2018

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Tandem Mass Tags: A Novel Quantification Strategy for Comparative Analysis of Complex Protein Mixtures by MS/MS

21 January 2018

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Cytoplasmic gelsolin increases mitochondrial activity and reduces Abeta burden in a mouse model of Alzheimer's disease.

21 January 2018

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Gelsolin is proteolytically cleaved in the brains of individuals with Alzheimer's disease

21 January 2018

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Peripheral transgene expression of plasma gelsolin reduces amyloid in transgenic mouse models of Alzheimer's disease.

21 January 2018

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Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer's disease

21 January 2018

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Alzheimer's disease beyond the genomic era: nuclear magnetic resonance (NMR) spectroscopy-based metabolomics.

21 January 2018

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Metabolomics: a global biochemical approach to the study of central nervous system diseases

21 January 2018

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Metabolomics tools for identifying biomarkers for neuropsychiatric diseases

21 January 2018

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Current strategies in the discovery of small-molecule biomarkers for Alzheimer's disease

21 January 2018

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Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics

21 January 2018

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Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/mass spectrometry

21 January 2018

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Serum sphingomyelins and ceramides are early predictors of memory impairment

21 January 2018

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Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology

21 January 2018

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Analysis of the adult human plasma metabolome

21 January 2018

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Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes

21 January 2018

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Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples

21 January 2018

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Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics

21 January 2018

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Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

21 January 2018

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Metabolome in progression to Alzheimer's disease

21 January 2018

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Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study

21 January 2018

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The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease

21 January 2018

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3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia

21 January 2018

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A high confidence, manually validated human blood plasma protein reference set

21 January 2018

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Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategy.

21 January 2018

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A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top-down and bottom-up proteomic analyses

21 January 2018

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A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells

21 January 2018

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Alterations of the microRNA network cause neurodegenerative disease.

21 January 2018

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MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.

21 January 2018

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Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus.

21 January 2018

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Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome

21 January 2018

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Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics

21 January 2018

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Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows

21 January 2018

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Oxidative stress hypothesis in Alzheimer's disease: a reappraisal

21 January 2018

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The role of inflammation in Alzheimer's disease

21 January 2018

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Identification of oxidized plasma proteins in Alzheimer's disease

21 January 2018

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Circulating biomarkers of protein oxidation for Alzheimer disease: expectations within limits

21 January 2018

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Aberrant profiles of native and oxidized glycoproteins in Alzheimer plasma

21 January 2018

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Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution

21 January 2018

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Plasma biomarkers of brain atrophy in Alzheimer's disease

21 January 2018

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Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

21 January 2018

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Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment

21 January 2018

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

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Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant.

21 January 2018

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Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

21 January 2018

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Proteomic analyses of human plasma: Venus versus Mars

21 January 2018

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A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.

21 January 2018

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Sample preparation for serum/plasma profiling and biomarker identification by mass spectrometry

21 January 2018

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Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease

21 January 2018

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Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease

21 January 2018

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Differences in abundances of cell-signalling proteins in blood reveal novel biomarkers for early detection of clinical Alzheimer's disease

21 January 2018

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Liquid Chromatography-Mass Spectrometry (LC-MS)-Based Lipidomics for Studies of Body Fluids and Tissues

21 January 2018

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A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease

21 January 2018

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Biomarkers for Alzheimer’s disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/BMM.12.48

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27 August 2017

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PubMed ID

22917146