The impact of differential antiviral immunity in children and adults (Q38037339)

27 August 2017

The impact of differential antiviral immunity in children and adults (English)

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27 August 2017

2

Paul Klenerman

1 reference

27 August 2017

Andrew J Prendergast

1

1 reference

PubMed ID

22918466

27 August 2017

Philip J R Goulder

series ordinal

3

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27 August 2017

1 September 2012

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Nature Reviews Immunology

27 August 2017

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27 August 2017

12

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27 August 2017

636-648

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27 August 2017

9

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Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis

27 August 2017

1 reference

Children who acquire HIV infection perinatally are at higher risk of early death than those acquiring infection through breastmilk: a meta-analysis

31 March 2020

1 reference

Child mortality according to maternal and infant HIV status in Zimbabwe

31 March 2020

1 reference

Virus levels in untreated African infants infected with human immunodeficiency virus type 1.

31 March 2020

1 reference

Pediatric HIV-1 in Kenya: pattern and correlates of viral load and association with mortality

31 March 2020

1 reference

Age- and time-related changes in extracellular viral load in children vertically infected by human immunodeficiency virus

31 March 2020

1 reference

Global epidemiology of hepatitis B virus

31 March 2020

1 reference

Risks of chronicity following acute hepatitis B virus infection: a review

31 March 2020

1 reference

Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine

31 March 2020

1 reference

Role of placental tissues in the intrauterine transmission of hepatitis B virus

31 March 2020

1 reference

A meta-analysis of lamivudine for interruption of mother-to-child transmission of hepatitis B virus

31 March 2020

1 reference

Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state

31 March 2020

1 reference

Age at first establishment of chronic hepatitis B virus infection and hepatocellular carcinoma risk. A birth order study

31 March 2020

1 reference

Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection

31 March 2020

1 reference

New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection

31 March 2020

1 reference

Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome.

31 March 2020

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Long-term outcome in preterm children with human cytomegalovirus infection transmitted via breast milk.

31 March 2020

1 reference

Low HCMV DNA copies can establish infection and result in significant symptoms in extremely preterm infants: a prospective study.

31 March 2020

1 reference

Urine viral load and correlation with disease severity in infants with congenital or postnatal cytomegalovirus infection.

31 March 2020

1 reference

Specific Cell-Mediated Immunity and the Natural History of Congenital Infection with Cytomegalovirus

31 March 2020

1 reference

Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells

31 March 2020

1 reference

Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

31 March 2020

1 reference

Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.

31 March 2020

1 reference

A critical role for murine complement regulator crry in fetomaternal tolerance

31 March 2020

1 reference

Regulatory T cells mediate maternal tolerance to the fetus

31 March 2020

1 reference

Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment

31 March 2020

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Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.

31 March 2020

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Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero

31 March 2020

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CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene.

31 March 2020

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Neonatal innate TLR-mediated responses are distinct from those of adults.

31 March 2020

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Innate immunity of the newborn: basic mechanisms and clinical correlates

31 March 2020

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Cytomegalovirus infection during pregnancy with maternofetal transmission induces a proinflammatory cytokine bias in placenta and amniotic fluid

31 March 2020

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Reduced levels of antimicrobial proteins and peptides in human cord blood plasma.

31 March 2020

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TLR3 deficiency in patients with herpes simplex encephalitis

31 March 2020

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Type I interferons in host defense

31 March 2020

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Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life.

31 March 2020

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Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors

31 March 2020

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The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.

31 March 2020

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Acquisition of adult-like TLR4 and TLR9 responses during the first year of life

31 March 2020

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Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells

31 March 2020

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Development of interleukin-12-producing capacity throughout childhood

31 March 2020

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Later development of Fas ligand-mediated cytotoxicity as compared with granule-mediated cytotoxicity during the maturation of natural killer cells

31 March 2020

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The expression of human natural killer cell receptors in early life

31 March 2020

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Characterization of cord blood natural killer cells: implications for transplantation and neonatal infections

31 March 2020

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Neonatal natural killer cells produce chemokines and suppress HIV replication in vitro

31 March 2020

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Natural killer cytotoxicity and antibody-dependent cellular cytotoxicity of human immunodeficiency virus-infected cells by leukocytes from human neonates and adults

31 March 2020

1 reference

Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection

31 March 2020

1 reference

Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

31 March 2020

1 reference

The influence of HLA genotype on AIDS

31 March 2020

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Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

31 March 2020

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Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

31 March 2020

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Novel, cross-restricted, conserved, and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type 1 infection

31 March 2020

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CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

31 March 2020

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HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

31 March 2020

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Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection

31 March 2020

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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

31 March 2020

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Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication

31 March 2020

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Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression

31 March 2020

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

31 March 2020

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

31 March 2020

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Differential Gag-specific polyfunctional T cell maturation patterns in HIV-1 elite controllers

31 March 2020

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HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

31 March 2020

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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control

31 March 2020

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Virus inhibition activity of effector memory CD8(+) T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection

31 March 2020

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HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control

31 March 2020

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Central role of reverting mutations in HLA associations with human immunodeficiency virus set point

31 March 2020

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

31 March 2020

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

31 March 2020

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Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

31 March 2020

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Restoring function in exhausted CD8 T cells during chronic viral infection

31 March 2020

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Enhancing SIV-specific immunity in vivo by PD-1 blockade

31 March 2020

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Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

31 March 2020

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

31 March 2020

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Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

31 March 2020

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Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

31 March 2020

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Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

31 March 2020

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HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

31 March 2020

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HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome

31 March 2020

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Antibody neutralization and escape by HIV-1

31 March 2020

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B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection

31 March 2020

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Antibodies, viruses and vaccines

31 March 2020

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Fc receptor but not complement binding is important in antibody protection against HIV.

31 March 2020

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Association of human immunodeficiency virus (HIV) load early in life with disease progression among HIV-infected infants. New York City Perinatal HIV Transmission Collaborative Study Group

31 March 2020

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Viral levels in newborn African infants undergoing primary HIV-1 infection

31 March 2020

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Early prognostic indicators in primary perinatal human immunodeficiency virus type 1 infection: importance of viral RNA and the timing of transmission on long-term outcome

31 March 2020

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High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis

31 March 2020

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Pediatric viral human immunodeficiency virus type 1 RNA levels, timing of infection, and disease progression in African HIV-1-infected children

31 March 2020

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Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group

31 March 2020

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Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infants

31 March 2020

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Identification of human immunodeficiency virus-1 specific CD8+ and CD4+ T cell responses in perinatally-infected infants and their mothers

31 March 2020

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Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants

31 March 2020

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Evolution and transmission of stable CTL escape mutations in HIV infection

31 March 2020

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Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection

31 March 2020

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Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants

31 March 2020

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HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load

31 March 2020

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Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment

31 March 2020

1 reference

Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infection

31 March 2020

1 reference

Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection

31 March 2020

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Factors influencing T cell activation and programmed death 1 expression in HIV-infected children

31 March 2020

1 reference

The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda

31 March 2020

1 reference

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

31 March 2020

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Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate

31 March 2020

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HIV-1-specific CD8+ T cell responses and viral evolution in women and infants

31 March 2020

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Correlates of spontaneous viral control among long-term survivors of perinatal HIV-1 infection expressing human leukocyte antigen-B57.

31 March 2020

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Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression

31 March 2020

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Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection

31 March 2020

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Profile of T cell immune responses in HIV-infected children from Uganda

31 March 2020

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Predictors of immunologic long-term nonprogression in HIV-infected children: implications for initiating therapy

31 March 2020

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Persistent immune activation in HIV-1 infection is associated with progression to AIDS.

31 March 2020

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Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

31 March 2020

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Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

31 March 2020

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Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.

31 March 2020

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Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host species

31 March 2020

1 reference

Hepatitis B virus immunopathogenesis

31 March 2020

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Hepatitis B infection: current concepts and future challenges.

31 March 2020

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The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.

31 March 2020

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Hepatitis B virus infection--natural history and clinical consequences

31 March 2020

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Hepatitis B: the virus and disease

31 March 2020

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Risk of hepatitis B virus (HBV) reactivation in hepatitis B surface antigen negative/hepatitis B core antibody positive patients receiving rituximab-containing combination chemotherapy without routine antiviral prophylaxis

31 March 2020

1 reference

Immune effectors required for hepatitis B virus clearance

31 March 2020

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Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms

31 March 2020

1 reference

Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection

31 March 2020

1 reference

Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection

31 March 2020

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Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection

31 March 2020

1 reference

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

31 March 2020

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Bayesian estimates of the evolutionary rate and age of hepatitis B virus

31 March 2020

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Temporal analysis of early immune responses in patients with acute hepatitis B virus infection

31 March 2020

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Genomic analysis of the host response to hepatitis B virus infection

31 March 2020

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Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

31 March 2020

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IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.

31 March 2020

1 reference

Immune response in neonates to hepatitis B vaccine

31 March 2020

1 reference

Effect of age on the incidence of acute hepatitis B after 25 years of a universal newborn hepatitis B immunization program in Taiwan.

31 March 2020

1 reference

Prevention of the HBsAg carrier state in newborn infants of mothers who are chronic carriers of HBsAg and HBeAg by administration of hepatitis-B vaccine and hepatitis-B immunoglobulin. Double-blind randomised placebo-controlled study

31 March 2020

1 reference

Antibody levels and immune memory 23 years after primary plasma-derived hepatitis B vaccination: results of a randomized placebo-controlled trial cohort from China where endemicity is high.

31 March 2020

1 reference

Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg+/HBeAg- mothers

31 March 2020

1 reference

Cellular immunity in children with successful immunoprophylactic treatment for mother-to-child transmission of hepatitis B virus

31 March 2020

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Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus

31 March 2020

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Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection

31 March 2020

1 reference

Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects

31 March 2020

1 reference

Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses

31 March 2020

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

31 March 2020

1 reference

Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8 T cells correlates with 'memory inflation' in human cytomegalovirus infection.

31 March 2020

1 reference

Report from the second cytomegalovirus and immunosenescence workshop

31 March 2020

1 reference

Memory inflation: continuous accumulation of antiviral CD8+ T cells over time.

31 March 2020

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Memory T cell inflation: understanding cause and effect

31 March 2020

1 reference

Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection

31 March 2020

1 reference

Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants

31 March 2020

1 reference

Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection

31 March 2020

1 reference

Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation

31 March 2020

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Maintenance of large subpopulations of differentiated CD8 T-cells two years after cytomegalovirus infection in Gambian infants

31 March 2020

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Cellular immune response of fetuses to cytomegalovirus

31 March 2020

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Mature CD8(+) T lymphocyte response to viral infection during fetal life

31 March 2020

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Comparison of CD8+ T Cell responses to cytomegalovirus between human fetuses and their transmitter mothers

31 March 2020

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Human cytomegalovirus elicits fetal gammadelta T cell responses in utero

31 March 2020

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Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children.

31 March 2020

1 reference

Herpesvirus latency confers symbiotic protection from bacterial infection

31 March 2020

1 reference

gamma-Herpesvirus-induced protection against bacterial infection is transient

31 March 2020

1 reference

Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity

31 March 2020

1 reference

Vaccine prevention of maternal cytomegalovirus infection

31 March 2020

1 reference

A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial.

31 March 2020

1 reference

Development of newborn and infant vaccines

31 March 2020

1 reference

Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial

31 March 2020

1 reference

Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system

31 March 2020

1 reference

Cytomegalovirus infection and HIV-1 disease progression in infants born to HIV-1-infected women. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection Study Group

31 March 2020

1 reference

Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy

31 March 2020

1 reference

Refined characterization and reference values of the pediatric T- and B-cell compartments

31 March 2020

1 reference

Long-term nonprogression of HIV infection in children: evaluation of the ANRS prospective French Pediatric Cohort

31 March 2020

1 reference

Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

31 March 2020

1 reference

Survival and prognostic indicators in hepatitis B surface antigen-positive cirrhosis of the liver

31 March 2020

1 reference

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

31 March 2020

1 reference

12 December 2020

The significance of spontaneous hepatitis B e antigen seroconversion in childhood: with special emphasis on the clearance of hepatitis B e antigen before 3 years of age

1 reference

12 December 2020

HIV-1-specific cytotoxic T lymphocyte responses in the first year of life

1 reference

12 December 2020

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1 reference

12 December 2020

1 reference

12 December 2020

Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge

1 reference

12 December 2020

Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile

1 reference

12 December 2020

Rates of mother-to-child transmission of HIV-1 in Africa, America, and Europe: results from 13 perinatal studies. The Working Group on Mother-To-Child Transmission of HIV

1 reference

12 December 2020

HIV-1 superinfection--a word of caution

1 reference

12 December 2020

Demography and presentation of chronic hepatitis B virus infection

1 reference

12 December 2020

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3277

1 reference

release_6rnuopklajac5nvkgtr4xn6lvq

27 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6rnuopklajac5nvkgtr4xn6lvq

24 November 2022

mapped directly with Wikidata item

PubMed ID

22918466

1 reference

PubMed ID

22918466