DNA methylation profiling in the clinic: applications and challenges (Q38040319)

27 August 2017

DNA methylation profiling in the clinic: applications and challenges (English)

1 reference

27 August 2017

0 references

2

1 reference

27 August 2017

Holger Heyn

1

0 references

language of work or name

1 reference

4 September 2012

1 reference

27 August 2017

Nature Reviews Genetics

1 reference

27 August 2017

13

1 reference

27 August 2017

10

1 reference

27 August 2017

679-692

1 reference

https://scigraph.springernature.com/pub.10.1038/nrg3270

27 August 2017

0 references

cites work

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

1 reference

High density DNA methylation array with single CpG site resolution

31 March 2020

1 reference

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications.

31 March 2020

1 reference

A decade of exploring the cancer epigenome - biological and translational implications

31 March 2020

1 reference

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

31 March 2020

1 reference

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

31 March 2020

1 reference

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains

31 March 2020

1 reference

Increased methylation variation in epigenetic domains across cancer types

31 March 2020

1 reference

Functions of DNA methylation: islands, start sites, gene bodies and beyond

31 March 2020

1 reference

Cancer epigenetics reaches mainstream oncology

31 March 2020

1 reference

Cancer epigenetics: from mechanism to therapy

31 March 2020

1 reference

BLUEPRINT to decode the epigenetic signature written in blood.

31 March 2020

1 reference

The NIH Roadmap Epigenomics Mapping Consortium

31 March 2020

1 reference

31 March 2020

Epigenetics in cancer

1 reference

Epigenetic gene silencing in cancer: the DNA hypermethylome

31 March 2020

1 reference

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

31 March 2020

1 reference

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

31 March 2020

1 reference

A DNA methylation fingerprint of 1628 human samples

31 March 2020

1 reference

Next-generation stool DNA test accurately detects colorectal cancer and large adenomas

31 March 2020

1 reference

Long interspersed nuclear element-1 hypomethylation is a potential biomarker for the prediction of response to oral fluoropyrimidines in microsatellite stable and CpG island methylator phenotype-negative colorectal cancer.

31 March 2020

1 reference

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

31 March 2020

1 reference

Phenotypic plasticity and the epigenetics of human disease

31 March 2020

1 reference

Aberrant epigenetic landscape in cancer: how cellular identity goes awry

31 March 2020

1 reference

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

31 March 2020

1 reference

Hypermethylation of CpG islands in primary and metastatic human prostate cancer.

31 March 2020

1 reference

Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma.

31 March 2020

1 reference

Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci.

31 March 2020

1 reference

The epigenetic promise for prostate cancer diagnosis

31 March 2020

1 reference

Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-captur

31 March 2020

1 reference

Promoter hypermethylation of GSTP1, AR, and 14-3-3sigma in serum of prostate cancer patients and its clinical relevance

31 March 2020

1 reference

CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer

31 March 2020

1 reference

Multimarker circulating DNA assay for assessing blood of prostate cancer patients

31 March 2020

1 reference

DNA-based detection of prostate cancer in urine after prostatic massage

31 March 2020

1 reference

Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects.

31 March 2020

1 reference

High concordance of gene methylation in post-digital rectal examination and post-biopsy urine samples for prostate cancer detection

31 March 2020

1 reference

Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening: a meta-analysis

31 March 2020

1 reference

CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer.

31 March 2020

1 reference

Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer.

31 March 2020

1 reference

DNA methylation biomarkers for blood-based colorectal cancer screening

31 March 2020

1 reference

Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer

31 March 2020

1 reference

Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer

31 March 2020

1 reference

Tumour and serum MGMT promoter methylation and protein expression in glioblastoma patients.

31 March 2020

1 reference

NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva.

31 March 2020

1 reference

Epigenetic modifications and human disease

31 March 2020

1 reference

Epigenetic differences arise during the lifetime of monozygotic twins

31 March 2020

1 reference

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

31 March 2020

1 reference

Twenty years of Alzheimer's disease-causing mutations

31 March 2020

1 reference

Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease

31 March 2020

1 reference

Distinct DNA methylomes of newborns and centenarians

31 March 2020

1 reference

DNA methylation markers and early recurrence in stage I lung cancer

31 March 2020

1 reference

Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression

31 March 2020

1 reference

Epigenetic disruption of cadherin-11 in human cancer metastasis.

31 March 2020

1 reference

A microRNA DNA methylation signature for human cancer metastasis

31 March 2020

1 reference

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia.

31 March 2020

1 reference

Genome-scale analysis of aberrant DNA methylation in colorectal cancer

31 March 2020

1 reference

The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer

31 March 2020

1 reference

DNA methylation profiling reveals a predominant immune component in breast cancers.

31 March 2020

1 reference

Breast cancer methylomes establish an epigenomic foundation for metastasis

31 March 2020

1 reference

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

31 March 2020

1 reference

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

31 March 2020

1 reference

MGMT gene silencing and benefit from temozolomide in glioblastoma

31 March 2020

1 reference

Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma

31 March 2020

1 reference

Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

31 March 2020

1 reference

Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms

31 March 2020

1 reference

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

31 March 2020

1 reference

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

31 March 2020

1 reference

CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer

31 March 2020

1 reference

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

31 March 2020

1 reference

BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors

31 March 2020

1 reference

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

31 March 2020

1 reference

Highly integrated single-base resolution maps of the epigenome in Arabidopsis

31 March 2020

1 reference

Human DNA methylomes at base resolution show widespread epigenomic differences

31 March 2020

1 reference

Dynamic changes in the human methylome during differentiation

31 March 2020

1 reference

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

31 March 2020

1 reference

The DNA methylome of human peripheral blood mononuclear cells

31 March 2020

1 reference

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis

31 March 2020

1 reference

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

31 March 2020

1 reference

Comprehensive high-throughput arrays for relative methylation (CHARM).

31 March 2020

1 reference

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

31 March 2020

1 reference

Epigenetic memory in induced pluripotent stem cells

31 March 2020

1 reference

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

31 March 2020

1 reference

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

31 March 2020

1 reference

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

31 March 2020

1 reference

MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome

31 March 2020

1 reference

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas

31 March 2020

1 reference

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

31 March 2020

1 reference

Methyl-DNA immunoprecipitation (MeDIP): hunting down the DNA methylome.

31 March 2020

1 reference

Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.

31 March 2020

1 reference

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

31 March 2020

1 reference

Conserved role of intragenic DNA methylation in regulating alternative promoters

31 March 2020

1 reference

Evaluation of the Infinium Methylation 450K technology

31 March 2020

1 reference

Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.

31 March 2020

1 reference

Identification of methylation and acetylation sites on mouse histone H3 using matrix-assisted laser desorption/ionization time-of-flight and nanoelectrospray ionization tandem mass spectrometry

31 March 2020

1 reference

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

31 March 2020

1 reference

Rapid analysis of CpG methylation patterns using RNase T1 cleavage and MALDI-TOF

31 March 2020

1 reference

Epigenetic modifications as therapeutic targets

31 March 2020

1 reference

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides

31 March 2020

1 reference

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

31 March 2020

1 reference

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

31 March 2020

1 reference

Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes

31 March 2020

1 reference

Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma

31 March 2020

1 reference

Selective inhibition of BET bromodomains

31 March 2020

1 reference

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

31 March 2020

1 reference

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

31 March 2020

1 reference

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

31 March 2020

1 reference

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

31 March 2020

1 reference

Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells

31 March 2020

1 reference

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

31 March 2020

1 reference

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

31 March 2020

1 reference

Epigenetic inactivation of CHFR in human tumors

31 March 2020

1 reference

Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant

31 March 2020

1 reference

Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

31 March 2020

1 reference

DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

31 March 2020

1 reference

IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer.

31 March 2020

1 reference

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

31 March 2020

1 reference

DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaborati

31 March 2020

1 reference

Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer.

31 March 2020

1 reference

Epigenetic alteration of PRKCDBP in colorectal cancers and its implication in tumor cell resistance to TNFα-induced apoptosis

31 March 2020

1 reference

14-3-3sigma methylation in pretreatment serum circulating DNA of cisplatin-plus-gemcitabine-treated advanced non-small-cell lung cancer patients predicts survival: The Spanish Lung Cancer Group

31 March 2020

1 reference

Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas

31 March 2020

1 reference

SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15.

31 March 2020

1 reference

TFAP2E-DKK4 and chemoresistance in colorectal cancer

31 March 2020

1 reference

The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer

31 March 2020

1 reference

Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

31 March 2020

1 reference

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

31 March 2020

1 reference

Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells

31 March 2020

1 reference

Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimens.

31 March 2020

1 reference

12 December 2020

Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients

1 reference

12 December 2020

A gene hypermethylation profile of human cancer

1 reference

12 December 2020

Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer

1 reference

12 December 2020

Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2

1 reference

12 December 2020

Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation.

1 reference

12 December 2020

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

1 reference

12 December 2020

Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis.

1 reference

12 December 2020

Molecular detection of prostate cancer in urine by GSTP1 hypermethylation

1 reference

12 December 2020

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

1 reference

12 December 2020

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients

1 reference

12 December 2020

Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG3270

1 reference

PubMed ID

22945394

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22945394