Cardioprotection: chances and challenges of its translation to the clinic (Q38055280)

27 August 2017

Cardioprotection: chances and challenges of its translation to the clinic (English)

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27 August 2017

Gerd Heusch

1

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PubMed ID

23095318

27 August 2017

language of work or name

English

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publication date

22 October 2012

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27 August 2017

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27 August 2017

381

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27 August 2017

166-175

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27 August 2017

9861

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The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis

27 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Pathophysiology of myocardial infarction: protection by ischemic pre- and postconditioning.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Myocardial hibernation: a delicate balance.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Coronary artery reperfusion. I. Early effects on local myocardial function and the extent of myocardial necrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

The role of glucose in the survival and 'recovery' of the anoxic isolated perfused rat heart

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Myocardial reperfusion: a double-edged sword?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

The "no-reflow" phenomenon after temporary coronary occlusion in the dog.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Postconditioning: old wine in a new bottle?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Myocardial reperfusion injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Cellular mechanisms of ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

We think we see a pattern emerging here

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

The late phase of preconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Bidirectional role of tumor necrosis factor-alpha in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Coronary microembolization: from bedside to bench and back to bedside

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote ischemic preconditioning: current knowledge, unresolved questions, and future priorities

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Cardioprotection: nitric oxide, protein kinases, and mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Postconditioning inhibits mitochondrial permeability transition

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

STAT5 activation and cardioprotection by remote ischemic preconditioning in humans: short communication

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Preconditioning the human heart during aorto-coronary bypass surgery.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Ischemic preconditioning in cardiac surgery: a word of caution

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Ischemic preconditioning prior to myocardial protection with cold blood cardioplegia in coronary surgery.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Ischaemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Normothermic retrograde blood cardioplegia with or without preceding ischemic preconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Preconditioning improves myocardial preservation in patients undergoing open heart operations.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Prospective, randomized clinical study of ischemic preconditioning as an adjunct to intermittent cold blood cardioplegia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Ischemic preconditioning improves preservation with cold blood cardioplegia in valve replacement patients

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of ischemic preconditioning on myocardial protection in coronary artery bypass graft patients : can the free radicals act as a trigger for ischemic preconditioning?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

The effect of preconditioning (ischemic and pharmacological) on myocardial necrosis following coronary artery bypass graft surgery

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

A comparison between ischemic preconditioning, intermittent cross-clamp fibrillation and cold crystalloid cardioplegia for myocardial protection during coronary artery bypass graft surgery

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Protection of the human heart with ischemic preconditioning during cardiac surgery: role of cardiopulmonary bypass

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effects of ischemic preconditioning in human heart

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Evaluation by cardiac troponin I: the effect of ischemic preconditioning as an adjunct to intermittent blood cardioplegia on coronary artery bypass grafting

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Postconditioning the human heart

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of postconditioning on coronary blood flow velocity and endothelial function in patients with acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Concordant improvements in coronary flow reserve and ST-segment resolution during percutaneous coronary intervention for acute myocardial infarction: a benefit of postconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Long-term benefit of postconditioning

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

A 60-s postconditioning protocol by percutaneous coronary intervention inhibits myocardial apoptosis in patients with acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Postconditioning the human heart in percutaneous coronary intervention

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Long-term follow-up of patients undergoing postconditioning during ST-elevation myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary intervention.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Does remote organ ischaemia trigger cardiac preconditioning during coronary artery surgery?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Increased C reactive protein and cardiac enzyme levels after coronary stent implantation. Is there protection by remote ischaemic preconditioning?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) Study: a prospective, randomized control trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

The effect of remote ischaemic preconditioning on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote perconditioning reduces myocardial injury in adult valve replacement: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote Ischemic Conditioning in Patients With Myocardial Infarction Treated With Primary Angioplasty: Impact on Left Ventricular Function Assessed by Comprehensive Echocardiography and Gated Single-Photon Emission CT.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Cardioprotective role of remote ischemic periconditioning in primary percutaneous coronary intervention: enhancement by opioid action

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of limb ischemic preconditioning on myocardial injury in patients undergoing mitral valve replacement surgery. -A randomized controlled trial-.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of remote ischaemic preconditioning on ischaemic-reperfusion injury in pulmonary hypertensive infants receiving ventricular septal defect repair

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass: a randomized controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote ischemic preconditioning applied during isoflurane inhalation provides no benefit to the myocardium of patients undergoing on-pump coronary artery bypass graft surgery: lack of synergy or evidence of antagonism in cardioprotection?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Remote ischaemic preconditioning reduces myocardial injury in patients undergoing heart valve surgery: randomised controlled trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

A pilot study investigating the effects of remote ischemic preconditioning in high-risk cardiac surgery using a randomised controlled double-blind protocol

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II).

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of high-dose intracoronary adenosine administration during primary percutaneous coronary intervention in acute myocardial infarction: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Myocardial salvage in acute myocardial infarction--challenges in clinical translation

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Erythropoietin in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a randomized, double-blind trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of cyclosporine on reperfusion injury in acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Beneficial impact of preconditioning during PTCA on creatine kinase release

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Nitroglycerin and delayed preconditioning in humans: yet another new mechanism for an old drug?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Ischemic preconditioning and preinfarction angina in the clinical arena

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Transient limb ischemia induces remote ischemic preconditioning in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Determination of the myocardial area at risk with pre- versus post-reperfusion imaging techniques in the pig model

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Loss of cardioprotection with ageing.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Failure to protect the myocardium against ischemia/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment: a potential role for phosphatase and tensin homolog deleted on chromosome ten?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Is impairment of ischaemic preconditioning by sulfonylurea drugs clinically important?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

SCIPIO brings new momentum to cardiac cell therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

Effect of remote ischemic preconditioning on clinical outcomes in patients undergoing coronary artery bypass graft surgery (ERICCA): rationale and study design of a multi-centre randomized double-blinded controlled clinical trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2812%2960916-7

7 January 2021

10.1016/S0140-6736(12)60916-7

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

23095318