Development of new drugs for an old target: the penicillin binding proteins. (Q38055325)

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16 February 2020

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30 January 2021

Development of new drugs for an old target: the penicillin binding proteins (English)

1 reference

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beta-lactamase inhibitors

16 February 2020

main subject

1 reference

30 January 2021

Astrid Zervosen

1

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16 February 2020

Eric Sauvage

2

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16 February 2020

Jean-Marie Frère

3

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16 February 2020

Paulette Charlier

4

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16 February 2020

André Luxen

5

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16 February 2020

language of work or name

English

0 references

publication date

24 October 2012

2 references

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16 February 2020

30 January 2021

2 references

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16 February 2020

30 January 2021

17

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16 February 2020

issue

11

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16 February 2020

page(s)

12478-12505

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Creative Commons Attribution 3.0 Unported

16 February 2020

copyright license

1 reference

Carbapenems: past, present, and future

30 January 2021

0 references

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Microbial drug discovery: 80 years of progress

21 January 2018

1 reference

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β-Lactam and glycopeptide antibiotics: first and last line of defense?

21 January 2018

1 reference

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Three decades of beta-lactamase inhibitors

21 January 2018

1 reference

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What antimicrobial resistance has taught us about horizontal gene transfer

21 January 2018

1 reference

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A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Diversity of beta-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

beta-lactam-resistant Streptococcus pneumoniae: epidemiology and evolutionary mechanism

21 January 2018

1 reference

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Bacterial resistance to antibiotics: modified target sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Of Pseudomonas, porins, pumps and carbapenems.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Has the era of untreatable infections arrived?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

The clinical consequences of antimicrobial resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Sustainable farming: Get pigs off antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

The 10 x '20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Newer antibacterial drugs for a new century

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Predictable and unpredictable evolution of antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Current challenges in antimicrobial chemotherapy: focus on ß-lactamase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

In vitro activity of NXL104 in combination with beta-lactams against Klebsiella pneumoniae isolates producing KPC carbapenemases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

In vitro activity of the {beta}-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

The future of the β-lactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Resistance drives antibacterial drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Ceftobiprole: first cephalosporin with activity against methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Ceftaroline fosamil: a new broad-spectrum cephalosporin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

In vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Large ring 1,3-bridged 2-azetidinones: experimental and theoretical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Inactivators in competition. How to deal with them ... and not!

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Use of biotinylated beta-lactams and chemiluminescence for study and purification of penicillin-binding proteins in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Soluble penicillin-binding protein 2a: beta-lactam binding and inhibition by non-beta-lactams using a 96-well format.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

A microtiter plate-based beta-lactam binding assay for inhibitors of high-molecular-mass penicillin-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Microtiter plate-based assay for inhibitors of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA)

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Structural Basis of the Inhibition of Class A β-Lactamases and Penicillin-Binding Proteins by 6-β-Iodopenicillanate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Novel fluorogenic substrates for imaging beta-lactamase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Cell-permeable near-infrared fluorogenic substrates for imaging beta-lactamase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

A detergent-based assay for the detection of promiscuous inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Screening in a spirit haunted world

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Serine Proteases: Structure and Mechanism of Catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Bridging cell wall biosynthesis and bacterial morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Potential transition state analogue inhibitors for the penicillin-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Crystal structure of Escherichia coli penicillin-binding protein 5 bound to a tripeptide boronic acid inhibitor: a role for Ser-110 in deacylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Crystal structure of a complex between the Actinomadura R39 DD-peptidase and a peptidoglycan-mimetic boronate inhibitor: interpretation of a transition state analogue in terms of catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Inhibition of a class C beta-lactamase by a specific phosphonate monoester

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Phosphonate monoester inhibitors of class A beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Crystal structure of an acylation transition-state analog of the TEM-1 beta-lactamase. Mechanistic implications for class A beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Inverse acyl phosph(on)ates: substrates or inhibitors of beta-lactam-recognizing enzymes?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Toward better antibiotics: crystallographic studies of a novel class of DD-peptidase/beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

pH, inhibitor, and substrate specificity studies on Escherichia coli penicillin-binding protein 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Hydrolytic stability versus ring size in lactams: implications for the development of lactam antibiotics and other serine protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Novel peptide inhibiting both TEM-1 β-lactamase and penicillin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

4-quinolones as noncovalent inhibitors of high molecular mass penicillin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

Binding of a non- β -lactam antibiotic to penicillin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES171112478

The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors

21 January 2018

1 reference

12 December 2020

Antibacterial properties of the bicyclic pyrazolidinones

1 reference

12 December 2020

Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams

1 reference

12 December 2020

Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications.

1 reference

12 December 2020

Breakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates

1 reference

12 December 2020

Lactivicin, a naturally occurring non-beta-lactam antibiotic having beta-lactam-like action: biological activities and mode of action.

1 reference

12 December 2020

Gamma-lactam analogues of beta-lactam antibiotics

1 reference

12 December 2020

Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C

1 reference

12 December 2020

Mode of interaction between beta-lactam antibiotics and the exocellular DD-carboxypeptidase--transpeptidase from Streptomyces R39

1 reference

12 December 2020

Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

1 reference

12 December 2020

3-Alkoxy-5-isoxazolidinones mimic β-lactams

1 reference

12 December 2020

Penicillin binding protein 2x as a major contributor to intrinsic beta-lactam resistance of Streptococcus pneumoniae

1 reference

12 December 2020

Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic Acid-based inhibitors of penicillin-binding proteins.

1 reference

12 December 2020

Synthesis, purification and kinetic properties of fluorescein-labelled penicillins

1 reference

12 December 2020

Synthesis and antibacterial activity of lactivicin derivatives

1 reference

12 December 2020

Synthesis and evaluation of ketophosph(on)ates as beta-lactamase inhibitors

1 reference

12 December 2020

Structure-activity studies of the inhibition of serine beta-lactamases by phosphonate monoesters

1 reference

12 December 2020

BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins

1 reference

12 December 2020

Chromogenic depsipeptide substrates for beta-lactamases and penicillin-sensitive DD-peptidases

1 reference

12 December 2020

Streptomyces K15 DD-peptidase-catalysed reactions with suicide beta-lactam carbonyl donors

1 reference

12 December 2020

Design and synthesis of bridged gamma-lactams as analogues of beta-lactam antibiotics.

1 reference

12 December 2020

10.3390/MOLECULES171112478

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23095893%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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16 February 2020

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