New concepts in the generation and functions of IgA. (Q38056035)

27 August 2017

title

New concepts in the generation and functions of IgA. (English)

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27 August 2017

Oliver Pabst

1

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27 August 2017

language of work or name

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29 October 2012

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Nature Reviews Immunology

27 August 2017

published in

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27 August 2017

volume

12

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27 August 2017

issue

12

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27 August 2017

page(s)

821-832

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Mucosal immunity: induction, dissemination, and effector functions

27 August 2017

cites work

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Secretory IgA: arresting microbial pathogens at epithelial borders

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21 January 2018

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Transient suppression of Shigella flexneri type 3 secretion by a protective O-antigen-specific monoclonal IgA

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Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer's patches with restriction to mucosal compartment.

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Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut

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The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity

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The human intestinal IgA response; burning questions.

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How vitamin A metabolizing dendritic cells are generated in the gut mucosa

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Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces

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The immune geography of IgA induction and function

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Memory B and memory plasma cells

21 January 2018

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Blood-borne human plasma cells in steady state are derived from mucosal immune responses

21 January 2018

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The life span of IgA plasma cells from the mouse intestine

21 January 2018

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Long-lived plasma cells from human small intestine biopsies secrete immunoglobulins for many weeks in vitro.

21 January 2018

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High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.

21 January 2018

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Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses

21 January 2018

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Organization of immunological memory by bone marrow stroma

21 January 2018

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Eosinophils are required for the maintenance of plasma cells in the bone marrow.

21 January 2018

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Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.

21 January 2018

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Human intestinal epithelial and smooth muscle cells are potent producers of IL-6.

21 January 2018

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Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation.

21 January 2018

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BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.

21 January 2018

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APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells

21 January 2018

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Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI.

21 January 2018

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Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.

21 January 2018

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A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.

21 January 2018

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Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine

21 January 2018

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Disquisitions of Original Antigenic Sin. I. Evidence in man

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Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.

21 January 2018

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Peyer's patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit

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Collaboration of epithelial cells with organized mucosal lymphoid tissues.

21 January 2018

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Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer's patches--a personal and historical perspective

21 January 2018

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Peyer's patch dendritic cells sample antigens by extending dendrites through M cell-specific transcellular pores

21 January 2018

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Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response

21 January 2018

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TACI and BAFF-R mediate isotype switching in B cells

21 January 2018

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Intestinal bacteria condition dendritic cells to promote IgA production

21 January 2018

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The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.

21 January 2018

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Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.

21 January 2018

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Identification and characterization of a novel regulatory factor: IgA-inducing protein

21 January 2018

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Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells

21 January 2018

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Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

21 January 2018

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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.

21 January 2018

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Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.

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Isolated lymphoid follicles can function as sites for induction of mucosal immune responses

21 January 2018

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Aging impacts isolated lymphoid follicle development and function

21 January 2018

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Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses?

21 January 2018

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Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

21 January 2018

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Critical roles of chemokine receptor CCR10 in regulating memory IgA responses in intestines

21 January 2018

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Isolated Lymphoid Follicles are Dynamic Reservoirs for the Induction of Intestinal IgA.

21 January 2018

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In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

21 January 2018

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Regulation of AID expression in the immune response

21 January 2018

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T cell-independent IgA class switch recombination is restricted to the GALT and occurs prior to manifest germinal center formation.

21 January 2018

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IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut.

21 January 2018

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Human intestinal IgA response is generated in the organized gut-associated lymphoid tissue but not in the lamina propria.

21 January 2018

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Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

21 January 2018

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Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria

21 January 2018

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Regulation of B1 cell migration by signals through Toll-like receptors

21 January 2018

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From the fetal liver to spleen and gut: the highway to natural antibody

21 January 2018

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Somatic hypermutation in peritoneal B1b cells.

21 January 2018

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Determinism and stochasticity during maturation of the zebrafish antibody repertoire

21 January 2018

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High-throughput sequencing of the zebrafish antibody repertoire

21 January 2018

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High-resolution description of antibody heavy-chain repertoires in humans

21 January 2018

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Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse

21 January 2018

1 reference

Evidence for local expansion of IgA plasma cell precursors in human ileum

21 January 2018

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Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts

21 January 2018

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IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated

21 January 2018

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IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans.

21 January 2018

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The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific

21 January 2018

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Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

21 January 2018

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Functional flexibility of intestinal IgA - broadening the fine line

21 January 2018

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In vivo IgA coating of anaerobic bacteria in human faeces

21 January 2018

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Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children

21 January 2018

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Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

21 January 2018

1 reference

Natural polyreactive immunoglobulin A antibodies produced in mouse Peyer's patches

21 January 2018

1 reference

Autoreactivity in human IgG+ memory B cells

21 January 2018

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Glycans on secretory component participate in innate protection against mucosal pathogens

21 January 2018

1 reference

Recognition of gram-positive intestinal bacteria by hybridoma- and colostrum-derived secretory immunoglobulin A is mediated by carbohydrates

21 January 2018

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Innate secretory antibodies protect against natural Salmonella typhimurium infection

21 January 2018

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Update on mucosal immunoglobulin A in gastrointestinal disease

21 January 2018

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Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut.

21 January 2018

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Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism

21 January 2018

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Rapid generation of rotavirus-specific human monoclonal antibodies from small-intestinal mucosa.

21 January 2018

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Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL

21 January 2018

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A mucosal IgA-mediated excretory immune system in vivo

21 January 2018

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THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT.

31 March 2020

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Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction

31 March 2020

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A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria

31 March 2020

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Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor

31 March 2020

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Cell surface recycling of internalized antigen permits dendritic cell priming of B cells

31 March 2020

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TGF-beta receptor signaling is critical for mucosal IgA responses

31 March 2020

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Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling

31 March 2020

1 reference

Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes

31 March 2020

1 reference

Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production

31 March 2020

1 reference

Long-Term Follow-Up and Outcome of a Large Cohort of Patients with Common Variable Immunodeficiency

31 March 2020

1 reference

The peritoneal micromilieu commits B cells to home to body cavities and the small intestine

31 March 2020

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Sequence analysis of light chain genes from human intestinal plasma cells demonstrates that lambda genes are almost all in-frame and highly mutated and most kappa genes are highly mutatedwhen in-frame and minimally mutated when out-of-frame

31 March 2020

2 references

31 March 2020

12 December 2020

Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses

1 reference

IgA response to symbiotic bacteria as a mediator of gut homeostasis

31 March 2020

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Protection against cholera toxin after oral immunization is thymus-dependent and associated with intestinal production of neutralizing IgA antitoxin

31 March 2020

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The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut

31 March 2020

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Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity

31 March 2020

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Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice.

31 March 2020

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

31 March 2020

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Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency

31 March 2020

1 reference

12 December 2020

Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut.

1 reference

12 December 2020

Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection

1 reference

12 December 2020

Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans

1 reference

12 December 2020

Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria

1 reference

12 December 2020

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12 December 2020

APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa

1 reference

12 December 2020

Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria.

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12 December 2020

Identifiers

DOI

10.1038/NRI3322

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27 August 2017

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