Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives. (Q38058785)

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Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives (English)

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pharmaceutical preparation

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Valeria Maria Morittu

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Domenico Britti

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Donato Cosco

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author name string

Cinzia Federico

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Elena Trapasso

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language of work or name

English

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publication date

1 November 2012

9 references

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International Journal of Nanomedicine

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25 June 2019

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5423-5436

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Creative Commons Attribution-NonCommercial 3.0 Unported

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copyright license

start time

1 November 2012

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April 2022 Public Data File from Crossref

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Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice

6 September 2017

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Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: the 'personalised' approach?

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In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer

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Targeted nanomedicines: effective treatment modalities for cancer, AIDS and brain disorders

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Recent advances in protection against doxorubicin-induced toxicity

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Novel approaches to deliver gemcitabine to cancers

6 September 2017

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Liposomal delivery improves the growth-inhibitory and apoptotic activity of low doses of gemcitabine in multiple myeloma cancer cells.

6 September 2017

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Polyaspartylhydrazide copolymer-based supramolecular vesicular aggregates as delivery devices for anticancer drugs.

6 September 2017

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Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes

6 September 2017

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Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential

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Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?

6 September 2017

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Pros and cons of the liposome platform in cancer drug targeting

6 September 2017

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Cellular pharmacology of gemcitabine

6 September 2017

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What is the best schedule for administration of gemcitabine-taxane?

6 September 2017

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PEGylation, successful approach to drug delivery

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Liposome opsonization

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The role of the liposomal anthracyclines and other systemic therapies in the management of advanced breast cancer

6 September 2017

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Cytotoxic effects of gemcitabine-loaded liposomes in human anaplastic thyroid carcinoma cells

6 September 2017

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Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies

6 September 2017

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Role of Gemcitabine in the Treatment of Advanced and Metastatic Breast Cancer

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Gemcitabine and tamoxifen-loaded liposomes as multidrug carriers for the treatment of breast cancer diseases

6 September 2017

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Folate-targeted supramolecular vesicular aggregates based on polyaspartyl-hydrazide copolymers for the selective delivery of antitumoral drugs

6 September 2017

1 reference

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Establishment and characterization of multidrug-resistant gastric cancer cell lines

14 September 2017

1 reference

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Anti-metastatic effects of liposomal gemcitabine in a human orthotopic LNCaP prostate cancer xenograft model

14 September 2017

1 reference

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Drug ratio-dependent antitumor activity of irinotecan and cisplatin combinations in vitro and in vivo.

14 September 2017

1 reference

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Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer

14 September 2017

1 reference

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Improved in vitro anti-tumoral activity, intracellular uptake and apoptotic induction of gemcitabine-loaded pegylated unilamellar liposomes

14 September 2017

1 reference

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Cytotoxic effects of a novel pyrazolopyrimidine derivative entrapped in liposomes in anaplastic thyroid cancer cells in vitro and in xenograft tumors in vivo

14 September 2017

1 reference

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Antitumoral activity of PEG-gemcitabine prodrugs targeted by folic acid

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

A new liposomal formulation of Gemcitabine is active in an orthotopic mouse model of pancreatic cancer accessible to bioluminescence imaging.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen

14 September 2017

1 reference

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Squalenoyl nanomedicines as potential therapeutics

14 September 2017

1 reference

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Combined effect of surface electrostatic charge and poly(ethyl glycol) on the association of liposomes with colon carcinoma cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Folate-mediated targeting of polymeric conjugates of gemcitabine.

14 September 2017

1 reference

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Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Antitumor activity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation

23 June 2018

1 reference

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Evasion of the Accelerated Blood Clearance Phenomenon by Coating of Nanoparticles with Various Hydrophilic Polymers

31 August 2018

1 reference

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Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Increased preclinical efficacy of irinotecan and floxuridine coencapsulated inside liposomes is associated with tumor delivery of synergistic drug ratios

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

The effective dispersion of nanovectors within the tumor microvasculature.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

ATP-containing immunoliposomes specific for cardiac myosin

31 August 2018

1 reference

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Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

A mechanistic study of the permeation kinetics through biomembrane models: gemcitabine-phospholipid bilayer interaction

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Change in pharmacokinetic and pharmacodynamic behavior of gemcitabine in human tumor xenografts upon entrapment in vesicular phospholipid gels

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes.

31 August 2018

1 reference

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Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490684

Antibody-modified liposomes for cancer chemotherapy

5 November 2018

1 reference

12 December 2020

Effects of Lipid Composition and Preparation Conditions on Physical-Chemical Properties, Technological Parameters and In Vitro Biological Activity of Gemcitabine-Loaded Liposomes

1 reference

12 December 2020

Liposomes as multicompartmental carriers for multidrug delivery in anticancer chemotherapy

1 reference

12 December 2020

Preparation and characterization of doxorubicin liposomes

1 reference

12 December 2020

Effect of liposome charge and PEG polymer layer thickness on cell-liposome electrostatic interactions

1 reference

12 December 2020

Gemcitabine: vascular toxicity and prothrombotic potential

1 reference

12 December 2020

Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo

1 reference

12 December 2020

Identifiers

DOI

10.2147/IJN.S34025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23139626%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23139626%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

PubMed publication ID

23139626

1 reference