The nuclear lamins: flexibility in function (Q38065087)

28 August 2017

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title

The nuclear lamins: flexibility in function (English)

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28 August 2017

Brian Burke

1

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28 August 2017

Colin L Stewart

series ordinal

2

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28 August 2017

language of work or name

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5 December 2012

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Nature Reviews Molecular Cell Biology

28 August 2017

published in

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28 August 2017

volume

14

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28 August 2017

issue

1

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28 August 2017

page(s)

13-24

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The nuclear lamina comes of age.

28 August 2017

cites work

1 reference

Transcription and the nuclear periphery: edge of darkness?

31 March 2020

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The nuclear envelope--a scaffold for silencing?

31 March 2020

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"Laminopathies": a wide spectrum of human diseases

31 March 2020

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Laminopathies and the long strange trip from basic cell biology to therapy

31 March 2020

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Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

31 March 2020

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Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models.

31 March 2020

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Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.

31 March 2020

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The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton

31 March 2020

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Blurring the boundary: the nuclear envelope extends its reach.

31 March 2020

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Functional architecture of the nuclear pore complex

31 March 2020

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Nuclear membrane proteins with potential disease links found by subtractive proteomics

31 March 2020

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Nuclear envelope transmembrane proteins (NETs) that are up-regulated during myogenesis

31 March 2020

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NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation

31 March 2020

1 reference

The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture

31 March 2020

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Regulation of myoblast differentiation by the nuclear envelope protein NET39

31 March 2020

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Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations

31 March 2020

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Nuclear lamina at the crossroads of the cytoplasm and nucleus

31 March 2020

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A modified procedure for the isolation of a pore complex-lamina fraction from rat liver nuclei

31 March 2020

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The nuclear envelope lamina is reversibly depolymerized during mitosis

31 March 2020

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Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution

31 March 2020

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31 March 2020

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cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins

31 March 2020

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Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins

31 March 2020

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Structure of the globular tail of nuclear lamin

31 March 2020

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The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy

31 March 2020

2 references

31 March 2020

12 December 2020

Cloning and sequencing of cDNA clones encoding chicken lamins A and B1 and comparison of the primary structures of vertebrate A- and B-type lamins

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A second higher vertebrate B-type lamin. cDNA sequence determination and in vitro processing of chicken lamin B2.

31 March 2020

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Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice

31 March 2020

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An alternative splicing product of the lamin A/C gene lacks exon 10.

31 March 2020

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Structural organization of the human gene (LMNB1) encoding nuclear lamin B1

31 March 2020

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cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells.

31 March 2020

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Isoprenylation is required for the processing of the lamin A precursor

31 March 2020

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The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2.

31 March 2020

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The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope

31 March 2020

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Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

31 March 2020

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Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

31 March 2020

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Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina

31 March 2020

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Evolution of the lamin protein family: what introns can tell

31 March 2020

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Characterization of the Hydra lamin and its gene: A molecular phylogeny of metazoan lamins

31 March 2020

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Solubility properties and specific assembly pathways of the B-type lamin from Caenorhabditis elegans

31 March 2020

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The nuclear lamina is a meshwork of intermediate-type filaments

31 March 2020

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The supramolecular organization of the C. elegans nuclear lamin filament

31 March 2020

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Expression of chicken lamin B2 in Escherichia coli: characterization of its structure, assembly, and molecular interactions

31 March 2020

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Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins

31 March 2020

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Filaments made from A- and B-type lamins differ in structure and organization

31 March 2020

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The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

31 March 2020

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Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

31 March 2020

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A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C.

31 March 2020

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31 March 2020

Lamin-binding Proteins

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Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B

31 March 2020

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Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy

31 March 2020

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Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

31 March 2020

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Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

31 March 2020

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Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

31 March 2020

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Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy

31 March 2020

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The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines

31 March 2020

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Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

31 March 2020

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LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090).

31 March 2020

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Lamin a truncation in Hutchinson-Gilford progeria.

31 March 2020

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

31 March 2020

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A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects

31 March 2020

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Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

31 March 2020

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Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

31 March 2020

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Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy

31 March 2020

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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

31 March 2020

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Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

31 March 2020

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An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

31 March 2020

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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

31 March 2020

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Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

31 March 2020

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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

31 March 2020

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A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

31 March 2020

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A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

31 March 2020

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Mapping of lamin A- and progerin-interacting genome regions

31 March 2020

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Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of beta-catenin

31 March 2020

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Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling

31 March 2020

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Breach of the nuclear lamina during assembly of herpes simplex viruses

31 March 2020

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Post-natal myogenic and adipogenic developmental: defects and metabolic impairment upon loss of A-type lamins.

31 March 2020

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Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease.

31 March 2020

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Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice

31 March 2020

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Prelamin A and lamin A appear to be dispensable in the nuclear lamina

31 March 2020

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Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.

31 March 2020

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Lamin B1 loss is a senescence-associated biomarker.

31 March 2020

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The role of nuclear lamin B1 in cell proliferation and senescence.

31 March 2020

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31 March 2020

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Lamin B1 is required for mouse development and nuclear integrity

31 March 2020

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Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

31 March 2020

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Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells

31 March 2020

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A mitotic lamin B matrix induced by RanGTP required for spindle assembly

31 March 2020

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Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency.

31 March 2020

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An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair.

31 March 2020

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Are B-type lamins essential in all mammalian cells?

31 March 2020

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Lamin B1 duplications cause autosomal dominant leukodystrophy

31 March 2020

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The nuclear localization of WAP and CSN genes is modified by lactogenic hormones in HC11 cells.

31 March 2020

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

31 March 2020

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Characterization of the Drosophila melanogaster genome at the nuclear lamina.

31 March 2020

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Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus.

31 March 2020

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Recruitment to the nuclear periphery can alter expression of genes in human cells

31 March 2020

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Transcriptional repression mediated by repositioning of genes to the nuclear lamina

31 March 2020

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A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence

31 March 2020

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Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

31 March 2020

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Binding of matrix attachment regions to lamin B1

31 March 2020

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Specific and conserved sequences in D. melanogaster and C. elegans lamins and histone H2A mediate the attachment of lamins to chromosomes

31 March 2020

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A chromatin binding site in the tail domain of nuclear lamins that interacts with core histones

31 March 2020

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Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase

31 March 2020

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Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR

31 March 2020

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LAP2 binds to BAF.DNA complexes: requirement for the LEM domain and modulation by variable regions

31 March 2020

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MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans

31 March 2020

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The Functions of Klarsicht and Nuclear Lamin in Developmentally Regulated Nuclear Migrations of Photoreceptor Cells in theDrosophilaEye

31 March 2020

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Role of ANC-1 in tethering nuclei to the actin cytoskeleton.

31 March 2020

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Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans

31 March 2020

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Coupling of the nucleus and cytoplasm: role of the LINC complex

31 March 2020

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SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton

31 March 2020

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The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope

31 March 2020

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LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins

31 March 2020

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Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye.

31 March 2020

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The nucleoskeleton as a genome-associated dynamic 'network of networks'.

31 March 2020

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Nuclei take a position: managing nuclear location

31 March 2020

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Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction

31 March 2020

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Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

31 March 2020

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Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin

31 March 2020

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Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope.

31 March 2020

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SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice

31 March 2020

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Understanding the roles of nuclear A- and B-type lamins in brain development

31 March 2020

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Nuclear envelope and lamin B2 function in the central nervous system

31 March 2020

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Local translation of extranuclear lamin B promotes axon maintenance

31 March 2020

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Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans

31 March 2020

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Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

31 March 2020

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Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

31 March 2020

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B-type lamins and their elusive roles in metazoan cell proliferation and senescence

31 March 2020

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The nuclear envelope as a signaling node in development and disease.

31 March 2020

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A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

31 March 2020

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Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope

31 March 2020

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Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells

31 March 2020

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Multiple modes of cytoplasmic dynein regulation

31 March 2020

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31 March 2020

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A role for cytoplasmic dynein and LIS1 in directed cell movement

31 March 2020

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Nucleokinesis in tangentially migrating neurons comprises two alternating phases: forward migration of the Golgi/centrosome associated with centrosome splitting and myosin contraction at the rear.

31 March 2020

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Cytoskeletal coordination during neuronal migration

31 March 2020

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Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue

31 March 2020

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Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy

31 March 2020

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12 December 2020

Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study.

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12 December 2020

Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C

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12 December 2020

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues

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12 December 2020

Identification of essential genes in cultured mammalian cells using small interfering RNAs.

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12 December 2020

Evidence for modification of lamin B by a product of mevalonic acid

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12 December 2020

Cells of the cellular immune and hemopoietic system of the mouse lack lamins A/C: distinction versus other somatic cells

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12 December 2020

The processing pathway of prelamin A

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12 December 2020

Organization and modulation of nuclear lamina structure

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12 December 2020

Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C

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12 December 2020

Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF

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12 December 2020

Characterization and quantitation of three B-type lamins in Xenopus oocytes and eggs: increase of lamin LI protein synthesis during meiotic maturation.

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12 December 2020

Identifiers

DOI

10.1038/NRM3488

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Dimensions Publication ID

28 August 2017

1042163948

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