Leptin therapy in type 2 diabetes (Q38065316)

28 August 2017

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title

Leptin therapy in type 2 diabetes (English)

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28 August 2017

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B P Cummings

1

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28 August 2017

21 January 2013

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Diabetes, Obesity and Metabolism

28 August 2017

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28 August 2017

15

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28 August 2017

7

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28 August 2017

607-612

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National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

28 August 2017

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Diabetes mellitus and cancer

21 January 2018

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Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies

21 January 2018

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End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions

21 January 2018

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Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats

21 January 2018

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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

21 January 2018

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Making insulin-deficient type 1 diabetic rodents thrive without insulin

21 January 2018

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Obese, a new mutation in the house mouse

21 January 2018

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Positional cloning of the mouse obese gene and its human homologue

21 January 2018

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Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

21 January 2018

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Leptin and the central nervous system control of glucose metabolism

21 January 2018

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Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

21 January 2018

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Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

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Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

21 January 2018

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Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

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Antidiabetic effects of IGFBP2, a leptin-regulated gene

21 January 2018

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Lipodystrophy: pathophysiology and advances in treatment

21 January 2018

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Efficacy of leptin therapy in the different forms of human lipodystrophy

21 January 2018

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Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.

21 January 2018

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Leptin-replacement therapy for lipodystrophy.

21 January 2018

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

21 January 2018

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Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

21 January 2018

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Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.

21 January 2018

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Serum leptin concentrations in children with type 1 diabetes mellitus: relationship to body mass index, insulin dose, and glycemic control.

21 January 2018

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Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes

21 January 2018

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Leptin deficiency causes insulin resistance induced by uncontrolled diabetes

21 January 2018

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Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

21 January 2018

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Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia

21 January 2018

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Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats

21 January 2018

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From lesions to leptin: hypothalamic control of food intake and body weight.

21 January 2018

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From observation to experimentation: leptin action in the mediobasal hypothalamus

21 January 2018

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Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

21 January 2018

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Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation

21 January 2018

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Leptin-dependent control of glucose balance and locomotor activity by POMC neurons.

21 January 2018

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Leptin therapy in insulin-deficient type I diabetes

21 January 2018

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

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Mechanisms for insulin resistance: common threads and missing links

21 January 2018

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Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin

21 January 2018

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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve

21 January 2018

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Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

21 January 2018

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Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

21 January 2018

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The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity

21 January 2018

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Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat

21 January 2018

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

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Consequences of stress in the secretory pathway: The ER stress response and its role in the metabolic syndrome

21 January 2018

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Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

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Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes

21 January 2018

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Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans

21 January 2018

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Leptin levels in obese women with and without type 2 diabetes mellitus

21 January 2018

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Leptin levels in diabetic and nondiabetic subjects.

21 January 2018

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Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

21 January 2018

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Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms

21 January 2018

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Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy

21 January 2018

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Leveraging leptin for type I diabetes?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/DOM.12048

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28 August 2017

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PubMed ID

23216672