BACE2 as a new diabetes target: a patent review (2010 - 2012). (Q38090741)

28 August 2017

BACE2 as a new diabetes target: a patent review (2010 - 2012). (English)

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28 August 2017

1

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PubMed ID

23506624

28 August 2017

language of work or name

English

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publication date

18 March 2013

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Expert Opinion on Therapeutic Patents

28 August 2017

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28 August 2017

23

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28 August 2017

5

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28 August 2017

649-663

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The worldwide diabetes epidemic

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Pharmacological management of type 2 diabetes mellitus: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Developing β-secretase inhibitors for treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

BACE1 dependent neuregulin processing: review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

InChI in the wild: an assessment of InChIKey searching in Google

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Conformationally biased P3 amide replacements of beta-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

BACE2 plays a role in the insulin receptor trafficking in pancreatic ß-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

Identification of BACE2 as an avid ß-amyloid-degrading protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.780032

10.1517/13543776.2013.780032

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23506624