The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies (Q38095200)

28 August 2017

The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies (English)

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28 August 2017

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4

G N De Iuliis

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28 August 2017

R J Aitken

1

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PubMed ID

23548339

28 August 2017

R Bronson

series ordinal

2

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PubMed ID

23548339

28 August 2017

T B Smith

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3

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28 August 2017

1 April 2013

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Molecular Human Reproduction

28 August 2017

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28 August 2017

19

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28 August 2017

8

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28 August 2017

475-485

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First recorded pregnancy and normal birth after ICSI using electrophoretically isolated spermatozoa.

28 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Free radicals, lipid peroxidation and sperm function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Redox regulation of human sperm function: from the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

On the possible origins of DNA damage in human spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Oxidative stress, DNA damage and the Y chromosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Prospective analysis of sperm-oocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Biological and clinical significance of DNA damage in the male germ line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

DNA fragmentation in morphologically normal spermatozoa: how much should we be concerned in the ICSI era?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

The importance of redox regulated pathways in sperm cell biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications--a position report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

A comparative study of oxidative DNA damage in mammalian spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Mouse spermatozoa contain a nuclease that is activated by pretreatment with EGTA and subsequent calcium incubation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Comparison of chromatin assays for DNA fragmentation evaluation in human sperm

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

The origins, patterns and implications of human spontaneous mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Reactive oxygen-induced reactive oxygen formation during human sperm capacitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Evaluation of correct endogenous reactive oxygen species content for human sperm capacitation and involvement of the NADPH oxidase system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Effects of H(2)O(2) exposure on human sperm motility parameters, reactive oxygen species levels and nitric oxide levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Sperm nuclear instability and staining with aniline blue: abnormal persistence of histones in spermatozoa in infertile men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Ascorbic acid protects against endogenous oxidative DNA damage in human sperm

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Smoking and low antioxidant levels increase oxidative damage to sperm DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Rare congenital disorders, imprinted genes, and assisted reproductive technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Outcomes for offspring of men having ICSI for male factor infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

DNA damage response during chromatin remodeling in elongating spermatids of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Atomic force microscope analysis of chromatin volumes in human sperm with head-shape abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Oxidative DNA damage in human sperm influences time to pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Spontaneous DNA fragmentation in swim-up selected human spermatozoa during long term incubation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Low rates of DNA fragmentation in selected motile human spermatozoa assessed by the TUNEL assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Effect of human sperm chromatin anomalies on fertilization outcome post-ICSI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Leukocytospermia is associated with increased reactive oxygen species production by human spermatozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Quantitative analysis of gene-specific DNA damage in human spermatozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

In vitro isoflavone supplementation reduces hydrogen peroxide-induced DNA damage in sperm

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Relative impact of oxidative stress on male reproductive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Clinical significance of sperm DNA damage in assisted reproduction outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

An endogenous nuclease in hamster, mouse, and human spermatozoa cleaves DNA into loop-sized fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Melatonin protects ram spermatozoa from cryopreservation injuries in a dose-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Impaired fertilizing ability of superoxide dismutase 1-deficient mouse sperm during in vitro fertilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Function of sperm chromatin structural elements in fertilization and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Are sperm chromatin and DNA defects relevant in the clinic?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

Are tests of sperm DNA damage clinically useful? Pros and cons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: development of an improved methodology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMOLEHR%2FGAT025

21 January 2018

Identifiers

DOI

10.1093/MOLEHR/GAT025

1 reference

28 August 2017

1 reference

PubMed ID

23548339