Strategies for enhanced peptide and protein delivery (Q38104408)

28 August 2017

Strategies for enhanced peptide and protein delivery (English)

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28 August 2017

Maelíosa T C McCrudden

1

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28 August 2017

Thakur Raghu Raj Singh

2

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28 August 2017

Katarzyna Migalska

3

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28 August 2017

Ryan F Donnelly

4

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28 August 2017

1 May 2013

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28 August 2017

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28 August 2017

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28 August 2017

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28 August 2017

593-614

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Expression in Escherichia coli of chemically synthesized genes for human insulin

28 August 2017

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The future of peptide-based drugs

21 January 2018

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Prospects in the total synthesis of protein therapeutics.

21 January 2018

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Longer action means better drug: tuning up protein therapeutics

21 January 2018

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Stability of protein pharmaceuticals

21 January 2018

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Stability of protein pharmaceuticals: an update

21 January 2018

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Past, present, and future technologies for oral delivery of therapeutic proteins

21 January 2018

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Protein aggregation--pathways and influencing factors

21 January 2018

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Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics

21 January 2018

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Immunogenicity assessment of therapeutic proteins and peptides

21 January 2018

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Pre-clinical considerations in the assessment of immunogenicity for protein therapeutics

21 January 2018

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Clinical pharmacology considerations in biologics development

21 January 2018

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Pharmacokinetic considerations for antibody drug conjugates

21 January 2018

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Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins

21 January 2018

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Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism

21 January 2018

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Pharmacokinetic aspects of biotechnology products

21 January 2018

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Techniques: new approaches to the delivery of biopharmaceuticals

21 January 2018

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Drug delivery systems: An updated review

21 January 2018

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Solid lipid nanoparticles as a drug delivery system for peptides and proteins

21 January 2018

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Nanoparticles as drug delivery systems.

21 January 2018

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Novel delivery technologies for protein and peptide therapeutics

21 January 2018

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Paracellular drug absorption enhancement through tight junction modulation

21 January 2018

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Zonula occludens toxin synthetic peptide derivative AT1002 enhances in vitro and in vivo intestinal absorption of low molecular weight heparin

21 January 2018

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Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo

21 January 2018

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Thiomers: a new generation of mucoadhesive polymers

21 January 2018

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Tight junction modulation and its relationship to drug delivery

21 January 2018

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Analysis of absorption enhancers in epithelial cell models

21 January 2018

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Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy

21 January 2018

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PEGylation of proteins and liposomes: a powerful and flexible strategy to improve the drug delivery

21 January 2018

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Acyl modified chitosan derivatives for oral delivery of insulin and curcumin

21 January 2018

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Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein

21 January 2018

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The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier.

21 January 2018

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Conjugated chitosan as a novel platform for oral delivery of paclitaxel

21 January 2018

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Diverse approaches for the enhancement of oral drug bioavailability

21 January 2018

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Enhanced bioavailability of nano-sized chitosan-atorvastatin conjugate after oral administration to rats

21 January 2018

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An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery

21 January 2018

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Preactivated thiomers as mucoadhesive polymers for drug delivery.

21 January 2018

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Thiomers: potential excipients for non-invasive peptide delivery systems

21 January 2018

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Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium

21 January 2018

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Protein and Peptide drug delivery: oral approaches

21 January 2018

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Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus: the glucose stabilization effects of HIM2.

21 January 2018

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Development of oral insulin: progress and current status

21 January 2018

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Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial

21 January 2018

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21 January 2018

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A dose range finding study of novel oral insulin (IN-105) under fed conditions in type 2 diabetes mellitus subjects

21 January 2018

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Chitosan-based delivery systems for protein therapeutics and antigens

21 January 2018

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Alternative routes of administration for systemic delivery of protein pharmaceuticals

21 January 2018

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Recent advances in buccal drug delivery and absorption--in vitro and in vivo studies

21 January 2018

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Buccal bioadhesive drug delivery--a promising option for orally less efficient drugs

21 January 2018

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Factors and strategies for improving buccal absorption of peptides.

21 January 2018

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Advances in oral transmucosal drug delivery

21 January 2018

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Peptidase activity on the surface of the porcine buccal mucosa

21 January 2018

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Evaluation of a novel, natural oligosaccharide gum as a sustained-release and mucoadhesive component of calcitonin buccal tablets.

21 January 2018

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Bioadhesive-based dosage forms: the next generation

21 January 2018

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Mucoadhesive interactions of amphiphilic cationic copolymers based on [2-(methacryloyloxy)ethyl]trimethylammonium chloride.

21 January 2018

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Chitosan and its derivatives: potential excipients for peroral peptide delivery systems

21 January 2018

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Lectin-mediated mucosal delivery of drugs and microparticles

21 January 2018

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Hydrogels for protein delivery

21 January 2018

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The buccal mucosa as an alternative route for the systemic delivery of risperidone

21 January 2018

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Nanoparticles for local drug delivery to the oral mucosa: proof of principle studies

21 January 2018

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Buccal penetration enhancers--how do they really work?

21 January 2018

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Modeling the oral cavity: in vitro and in vivo evaluations of buccal drug delivery systems.

21 January 2018

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Nasal drug delivery--possibilities, problems and solutions

21 January 2018

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Delivery of peptide and non-peptide drugs through the respiratory tract

21 January 2018

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Transport of drugs from the nasal cavity to the central nervous system

21 January 2018

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Nasal route and drug delivery systems

21 January 2018

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Nanoparticles for direct nose-to-brain delivery of drugs.

21 January 2018

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Nasal delivery of high molecular weight drugs.

21 January 2018

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The nasal mucociliary clearance: relevance to nasal drug delivery

21 January 2018

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Drug metabolism in the nasal mucosa

21 January 2018

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Nasal delivery of insulin using bioadhesive chitosan gels

21 January 2018

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Aminated gelatin microspheres as a nasal delivery system for peptide drugs: evaluation of in vitro release and in vivo insulin absorption in rats.

21 January 2018

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Effects of proteolytic enzyme inhibitors as absorption enhancers on the transdermal iontophoretic delivery of calcitonin in rats

21 January 2018

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Commercial challenges of protein drug delivery

21 January 2018

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Absorption enhancers in pulmonary protein delivery

21 January 2018

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21 January 2018

Pfizer dumps Exubera.

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Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery

21 January 2018

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Technosphere insulin: defining the role of Technosphere particles at the cellular level

21 January 2018

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Pharmacokinetic characterization of the novel pulmonary delivery excipient fumaryl diketopiperazine

21 January 2018

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Technosphere insulin technology.

21 January 2018

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Technosphere insulin effectively controls postprandial glycemia in patients with type 2 diabetes mellitus.

21 January 2018

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Interleukin-2 liposomes for primary immune deficiency using the aerosol route

21 January 2018

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Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers.

21 January 2018

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Liposomal delivery of proteins and peptides

21 January 2018

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Degradation of insulin by trypsin and alpha-chymotrypsin.

21 January 2018

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The effect of absorption enhancers on the initial degradation kinetics of insulin by alpha-chymotrypsin

21 January 2018

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The use of mucoadhesive polymers in vaginal delivery

21 January 2018

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Vaginal absorption of a potent luteinizing hormone-releasing hormone analog (leuprolide) in rats I: absorption by various routes and absorption enhancement.

21 January 2018

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Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans

21 January 2018

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Niosomes with sorbitan monoester as a carrier for vaginal delivery of insulin: studies in rats

21 January 2018

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Niosomes: a controlled and novel drug delivery system

21 January 2018

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Vaginal DNA vaccination against infectious diseases transmitted through the vagina

21 January 2018

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Characterisation of protein stability in rod-insert vaginal rings.

21 January 2018

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Effect of different bile salts on the relative hypoglycemia of witepsol W35 suppositories containing insulin in diabetic Beagle dogs

21 January 2018

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Approaches for breaking the barriers of drug permeation through transdermal drug delivery

21 January 2018

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Emerging strategies for the transdermal delivery of peptide and protein drugs

21 January 2018

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Proteins and peptides: strategies for delivery to and across the skin

21 January 2018

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Penetration of nanoparticles and nanomaterials in the skin: fiction or reality?

21 January 2018

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Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs

21 January 2018

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Novel mechanisms and devices to enable successful transdermal drug delivery

21 January 2018

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Transdermal delivery of nalbuphine and its prodrugs by electroporation

21 January 2018

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Effect of controlled laser microporation on drug transport kinetics into and across the skin

21 January 2018

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Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety

21 January 2018

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Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique

21 January 2018

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Transdermal delivery of insulin using microneedles in vivo

21 January 2018

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Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery

21 January 2018

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Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization

21 January 2018

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Dissolving microneedle patch for transdermal delivery of human growth hormone

21 January 2018

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Microneedle delivery of plasmid DNA to living human skin: Formulation coating, skin insertion and gene expression

21 January 2018

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DNA vaccination in the skin using microneedles improves protection against influenza

21 January 2018

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A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens

21 January 2018

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Infusion pressure and pain during microneedle injection into skin of human subjects

21 January 2018

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Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery

21 January 2018

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Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery

21 January 2018

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Buccal drug delivery: A challenge already won?

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/TDE.13.31

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28 August 2017

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