HMGA2 and high-grade serous ovarian carcinoma (Q38107833)

29 August 2017

title

HMGA2 and high-grade serous ovarian carcinoma (English)

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29 August 2017

Jingjing Wu

1

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29 August 2017

Jian-Jun Wei

series ordinal

2

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29 August 2017

publication date

19 May 2013

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Journal of Molecular Medicine

29 August 2017

published in

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29 August 2017

volume

91

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29 August 2017

issue

10

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29 August 2017

page(s)

1155-1165

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Roles of HMGA proteins in cancer

29 August 2017

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HMGA2 participates in transformation in human lung cancer

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HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes

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Fusion of HMGA2 to COG5 in uterine leiomyoma

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Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease.

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HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma

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Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers.

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Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis

21 January 2018

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Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

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Let-7 expression defines two differentiation stages of cancer

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Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2

21 January 2018

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The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

21 January 2018

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miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors

21 January 2018

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MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.

21 January 2018

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Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells

21 January 2018

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WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer

21 January 2018

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Suppression of lung adenocarcinoma progression by Nkx2-1

21 January 2018

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Chromatin immunoprecipitation to analyze DNA binding sites of HMGA2

21 January 2018

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Genome-wide analysis of HMGA2 transcription factor binding sites by ChIP on chip in gastric carcinoma cells

21 January 2018

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HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

21 January 2018

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Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.

21 January 2018

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Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

21 January 2018

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HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells

21 January 2018

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The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?

21 January 2018

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DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells

21 January 2018

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High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells

21 January 2018

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Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells

21 January 2018

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Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression

21 January 2018

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let-7 regulates self renewal and tumorigenicity of breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

Critical role of the HMGA2 gene in pituitary adenomas

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2

21 January 2018

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p14Arf acts as an antagonist of HMGA2 in senescence of mesenchymal stem cells-implications for benign tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

Suppression of nonhomologous end joining repair by overexpression of HMGA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells

21 January 2018

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Comment re: HMGA2 is a negative regulator of DNA-PK pathway.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

Genomic analysis of epithelial ovarian cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

The biology of ovarian cancer: new opportunities for translation

21 January 2018

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Rethinking ovarian cancer: recommendations for improving outcomes

21 January 2018

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Integrated genomic analyses of ovarian carcinoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

HMGA2 gene is a promising target for ovarian cancer silencing therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

HMGA2 overexpression in non-small cell lung cancer.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

Fusion genes in solid tumors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

21 January 2018

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The genesis and evolution of high-grade serous ovarian cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1055-8

New insights into the pathogenesis of serous ovarian cancer and its clinical impact

21 January 2018

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A candidate precursor to serous carcinoma that originates in the distal fallopian tube.

21 January 2018

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Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada

21 January 2018

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Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

21 January 2018

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Modulation of microRNA processing by p53

21 January 2018

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Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest

21 January 2018

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

21 January 2018

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Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer

21 January 2018

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Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

21 January 2018

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The role of BRCA1 in DNA damage response

21 January 2018

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Functional interaction between FOXO3a and ATM regulates DNA damage response

21 January 2018

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Primary ex vivo cultures of human fallopian tube epithelium as a model for serous ovarian carcinogenesis.

21 January 2018

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Changes in nuclear proteins on transformation of rat epithelial thyroid cells by a murine sarcoma retrovirus

21 January 2018

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12 December 2020

Probing into the biological processes influenced by ESC factor and oncoprotein HMGA2 using iPSCs

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12 December 2020

Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells.

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12 December 2020

HMGA2: a potential biomarker complement to P53 for detection of early-stage high-grade papillary serous carcinoma in fallopian tubes

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12 December 2020

HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors

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12 December 2020

The HMGA proteins: a myriad of functions (Review).

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12 December 2020

Misexpression of full-length HMGA2 induces benign mesenchymal tumors in mice

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12 December 2020

HMGA2: a biomarker significantly overexpressed in high-grade ovarian serous carcinoma

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12 December 2020

Thymosin {beta}(10) inhibits angiogenesis and tumor growth by interfering with Ras function

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12 December 2020

Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15

1 reference

12 December 2020

Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?

1 reference

12 December 2020

The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.

1 reference

12 December 2020

Assessment of TP53 mutation using purified tissue samples of ovarian serous carcinomas reveals a higher mutation rate than previously reported and does not correlate with drug resistance

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12 December 2020

Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma

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12 December 2020

Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas

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12 December 2020

Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer

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12 December 2020

The oncogenic properties of the HMG-I gene family.

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12 December 2020

Evidence for RAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma

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12 December 2020

Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases

1 reference

12 December 2020

HMGA2 elicits EMT by activating the Wnt/β-catenin pathway in gastric cancer

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12 December 2020

HMGA2 protein expression in ovarian serous carcinoma effusions, primary tumors, and solid metastases

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12 December 2020

MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2

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12 December 2020

Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma: identification of a novel type of LPP-HMGA2 transcript in four cases.

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12 December 2020

10.1007/S00109-013-1055-8

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

1051732079

0 references

1 reference