Preclinical models of multiple myeloma: a critical appraisal (Q38112468)

29 August 2017

Preclinical models of multiple myeloma: a critical appraisal (English)

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29 August 2017

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Julia Schüler

1

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29 August 2017

Daniel Ewerth

2

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29 August 2017

Johannes Waldschmidt

3

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29 August 2017

Ralph Wäsch

4

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29 August 2017

Monika Engelhardt

5

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29 August 2017

language of work or name

English

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publication date

7 June 2013

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Expert Opinion on Biological Therapy

29 August 2017

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29 August 2017

13 Suppl 1

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29 August 2017

S111-23

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European Myeloma Network: the 3rd Trialist Forum Consensus Statement from the European experts meeting on multiple myeloma.

29 August 2017

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Challenging the current approaches to multiple myeloma- and other cancer-related bone diseases: from bisphosphonates to targeted therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Human hemato-lymphoid system mice: current use and future potential for medicine

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Early and mature endothelial progenitors and VEGFR2+-cells in multiple myeloma: association with disease characteristics and variation in different cell compartments.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Characterization of in vitro growth of multiple myeloma cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Extravasation and homing mechanisms in multiple myeloma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Hallmarks of Cancer: The Next Generation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Hallmarks of cancer: interactions with the tumor stroma.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Leukemia stem cells and microenvironment: biology and therapeutic targeting

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

The leukemic stem cell niche: current concepts and therapeutic opportunities

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

IL-6 regulates CD44 cell surface expression on human myeloma cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Hypoxia-inducible factors, stem cells, and cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Molecular pathogenesis and a consequent classification of multiple myeloma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Potent in vitro and in vivo activity of sorafenib in multiple myeloma: induction of cell death, CD138-downregulation and inhibition of migration through actin depolymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Phenotypic characterization of the human myeloma cell growth fraction

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Conditions controlling the proliferation of haemopoietic stem cells in vitro

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Role of decorin in the antimyeloma effects of osteoblasts

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Osteoblastogenesis and tumor growth in myeloma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A comparison of cytokine production in 2-dimensional and 3-dimensional cultures of bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Growth and differentiation of bone marrow stromal cells on biodegradable polymer scaffolds: an in vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Evaluation of mineralized collagen and alpha-tricalcium phosphate as scaffolds for tissue engineering of bone using human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Diversity of human leukemia xenograft mouse models: implications for disease biology

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Of mice and humans: are they the same?--Implications in cancer translational research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A model of multiple myeloma: culture of 5T33 murine myeloma cells and evaluation of tumorigenicity in the C57BL/KaLwRij mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Increased regulatory versus effector T cell development is associated with thymus atrophy in mouse models of multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

An update on the xenograft and mouse models suitable for investigating new therapeutic compounds for the treatment of B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A germline-competent embryonic stem cell line from NOD.Cg-Prkdc ( scid ) Il2rg ( tm1Wjl )/SzJ (NSG) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Highly activated and expanded natural killer cells for multiple myeloma immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Antimyeloma efficacy of thalidomide in the SCID-hu model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A clinically relevant SCID-hu in vivo model of human multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Therapeutic effects of intrabone and systemic mesenchymal stem cell cytotherapy on myeloma bone disease and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Human placenta-derived adherent cells prevent bone loss, stimulate bone formation, and suppress growth of multiple myeloma in bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Preclinical molecular imaging using PET and MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Sensitive dual color in vivo bioluminescence imaging using a new red codon optimized firefly luciferase and a green click beetle luciferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Optical imaging of disseminated leukemia models in mice with near-infrared probe conjugated to a monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Emerging therapies targeting tumor vasculature in multiple myeloma and other hematologic and solid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2013.799131

10.1517/14712598.2013.799131

21 January 2018

Identifiers

DOI

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29 August 2017

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