Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease (Q38116974)

29 August 2017

Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease (English)

1 reference

29 August 2017

0 references

Emma Louise Ashby

1

1 reference

29 August 2017

Patrick G Kehoe

series ordinal

2

1 reference

29 August 2017

language of work or name

English

0 references

publication date

26 June 2013

1 reference

Expert Opinion on Investigational Drugs

29 August 2017

1 reference

29 August 2017

22

1 reference

29 August 2017

10

1 reference

29 August 2017

1229-1242

1 reference

Distinguishing Alzheimer's disease from other major forms of dementia

29 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Toward a pathological definition of vascular dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Pathology and pathogenesis of vascular cognitive impairment-a critical update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Alzheimer's disease: clinical trials and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Renin-angiotensin system revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Cellular mechanism of vasoconstriction induced by angiotensin II: it remains to be determined.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Roles of Brain Angiotensin II in Cognitive Function and Dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Safety and efficacy of aliskiren in the treatment of hypertension and associated clinical conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Role of Hypertension in Aggravating Abeta Neuropathology of AD Type and Tau-Mediated Motor Impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Blood pressure trajectories from midlife to late life in relation to dementia in women followed for 37 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Midlife blood pressure and dementia: the Honolulu-Asia aging study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Antihypertensive therapy is associated with reduced rate of conversion to Alzheimer's disease in midregional proatrial natriuretic peptide stratified subjects with mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Antihypertensive medication use and incident Alzheimer disease: the Cache County Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Placebo-controlled trials of blood pressure-lowering therapies for primary prevention of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

The Study on COgnition and Prognosis in the Elderly (SCOPE); outcomes in patients not receiving add-on therapy after randomization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: results of a pilot randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Influence of losartan and atenolol on memory function in very elderly hypertensive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Effect of telmisartan/hydrochlorothiazide vs lisinopril/hydrochlorothiazide combination on ambulatory blood pressure and cognitive function in elderly hypertensive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Abeta-degrading enzymes in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Examination of the current top candidate genes for AD in a genome-wide association study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II-induced calcium signalling in neurons and astrocytes of rat circumventricular organs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II binding to angiotensin I-converting enzyme triggers calcium signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Telmisartan prevented cognitive decline partly due to PPAR-gamma activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Glycogen synthase kinase-3beta negatively regulates TGF-beta1 and Angiotensin II-mediated cellular activity through interaction with Smad3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Acetylcholinesterase inhibitors: a patent review (2008 - present).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Identification and characterization of a functional mitochondrial angiotensin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II induced cerebral microvascular inflammation and increased blood-brain barrier permeability via oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II modulates BBB permeability via activation of the AT(1) receptor in brain endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Precocious activation of genes of the renin-angiotensin system and the fibrogenic cascade in IgA glomerulonephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II sustains brain inflammation in mice via TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Direct stimulation of angiotensin II type 2 receptor enhances spatial memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Drug repositioning for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensins in Alzheimer's disease - friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Strain differences in the effects of angiotensin IV on mouse cognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Brain renin-angiotensin--a new look at an old system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Commentary ( The Renin Angiotensin System in Alzheimers Disease - Do Updates Highlight a Clinical and Biological Dichotomy? )

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.812631

10.1517/13543784.2013.812631

21 January 2018

Identifiers

DOI

1 reference

release_xktb7jfmbjcthppouudfya2zji

29 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xktb7jfmbjcthppouudfya2zji

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference