Targeting metallo-β-lactamase enzymes in antibiotic resistance (Q38121932)

29 August 2017

Targeting metallo-β-lactamase enzymes in antibiotic resistance (English)

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29 August 2017

antibiotic resistance

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Dustin T King

1

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PubMed ID

23859206

29 August 2017

Natalie C J Strynadka

series ordinal

2

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29 August 2017

1 July 2013

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Future Medicinal Chemistry

29 August 2017

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29 August 2017

5

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29 August 2017

1243-1263

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29 August 2017

11

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Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics

29 August 2017

1 reference

An Enzyme from Bacteria able to Destroy Penicillin

21 January 2018

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Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily

21 January 2018

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Zinc as a cofactor for cephalosporinase from Bacillus cereus 569.

21 January 2018

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Transferable imipenem resistance in Pseudomonas aeruginosa

21 January 2018

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Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636.

21 January 2018

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Standard numbering scheme for class B beta-lactamases

21 January 2018

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Aztreonam. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

21 January 2018

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Detection of NDM-1-producing Klebsiella pneumoniae in Kenya

21 January 2018

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IMP-1 metallo-beta-lactamase: effect of chelators and assessment of metal requirement by electrospray mass spectrometry.

21 January 2018

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Therapeutic iron chelators and their potential side-effects

21 January 2018

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An X-ray-crystallographic study of beta-lactamase II from Bacillus cereus at 0.35 nm resolution

21 January 2018

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Metallo-beta-lactamase: structure and mechanism

21 January 2018

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Role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-beta-lactamases

21 January 2018

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Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance

21 January 2018

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The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form

21 January 2018

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Analysis of the importance of the metallo-beta-lactamase active site loop in substrate binding and catalysis

21 January 2018

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A metallo-beta-lactamase enzyme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem

21 January 2018

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Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.

21 January 2018

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The mechanisms of catalysis by metallo beta-lactamases

21 January 2018

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Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril

21 January 2018

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Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase

21 January 2018

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Role of zinc content on the catalytic efficiency of B1 metallo beta-lactamases

21 January 2018

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Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1.

21 January 2018

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Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism

21 January 2018

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New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition

21 January 2018

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Catalytic mechanism of class B2 metallo-beta-lactamase.

21 January 2018

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Crystal structure of Serratia fonticola Sfh-I: activation of the nucleophile in mono-zinc metallo-β-lactamases.

21 January 2018

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Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography

21 January 2018

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The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria.

21 January 2018

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A thiono-beta-lactam substrate for the beta-lactamase II of Bacillus cereus. Evidence for direct interaction between the essential metal ion and substrate

21 January 2018

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The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives

21 January 2018

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Inhibitors of metallo-beta-lactamase generated from beta-lactam antibiotics.

21 January 2018

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Inactivation of Aeromonas hydrophila metallo-beta-lactamase by cephamycins and moxalactam

21 January 2018

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Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases

21 January 2018

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NMR characterization of the metallo-beta-lactamase from Bacteroides fragilis and its interaction with a tight-binding inhibitor: role of an active-site loop

21 January 2018

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In vitro antibacterial activity and mechanism of action of J-111,225, a novel 1beta-methylcarbapenem, against transferable IMP-1 metallo-beta-lactamase producers.

21 January 2018

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Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

21 January 2018

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Cyclobutanone mimics of penicillins: effects of substitution on conformation and hemiketal stability

21 January 2018

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Cyclobutanone analogues of beta-lactams revisited: insights into conformational requirements for inhibition of serine- and metallo-beta-lactamases

21 January 2018

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Zinc and sulfur: a critical biological partnership

21 January 2018

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Coordination geometries of metal ions in d- or l-captopril-inhibited metallo-beta-lactamases

21 January 2018

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The 1.5-A structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, D-captopril

21 January 2018

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Structural insights into the design of inhibitors for the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia

21 January 2018

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Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols

21 January 2018

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Homo-cysteinyl peptide inhibitors of the L1 metallo-beta-lactamase, and SAR as determined by combinatorial library synthesis

21 January 2018

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Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.

21 January 2018

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Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor

21 January 2018

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Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies

21 January 2018

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The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding

21 January 2018

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Irreversible inhibition of metallo-beta-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)propionic acid pentafluorophenyl ester

21 January 2018

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Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase

21 January 2018

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Novel IMP-1 metallo-beta-lactamase inhibitors can reverse meropenem resistance in Escherichia coli expressing IMP-1.

21 January 2018

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In vitro potentiation of carbapenems with ME1071, a novel metallo-beta-lactamase inhibitor, against metallo-beta-lactamase- producing Pseudomonas aeruginosa clinical isolates

21 January 2018

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Metallo-beta-lactamase inhibitory activity of phthalic acid derivatives.

21 January 2018

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Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa.

21 January 2018

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Competitive Inhibitors of the CphA Metallo- -Lactamase from Aeromonas hydrophila

21 January 2018

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New leads of metallo-beta-lactamase inhibitors from structure-based pharmacophore design.

21 January 2018

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NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies

21 January 2018

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Antibiotic resistance in bacteria: novel metalloenzyme inhibitors

21 January 2018

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A specific peptide inhibitor of the class B metallo-beta-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display

21 January 2018

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Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases

21 January 2018

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N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-beta-lactamase

21 January 2018

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Rapid identification of metallo- and serine beta-lactamases

21 January 2018

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Efficacy of calcium-EDTA as an inhibitor for metallo-β-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia

21 January 2018

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Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase

21 January 2018

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N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.13.55

1 reference

29 August 2017

1 reference

PubMed ID

23859206