Hype or hypervirulence: a reflection on problematic C. difficile strains. (Q38141579)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

2 references

13 November 2020

18 October 2022

Hype or hypervirulence: a reflection on problematic C. difficile strains (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json

biomedical investigative technique

22 February 2020

main subject

Clostridium difficile

0 references

1 reference

19 September 2019

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2 November 2019

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13 November 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author name string

Wiep Klaas Smits

series ordinal

1

1 reference

29 August 2017

10 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 October 2013

2 references

13 November 2020

18 October 2022

6 references

23 March 2019

19 September 2019

2 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

13 November 2020

18 October 2022

4

1 reference

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22 February 2020

issue

7

1 reference

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22 February 2020

page(s)

592-596

1 reference

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Creative Commons Attribution-NonCommercial 3.0 Unported

22 February 2020

copyright license

5 references

23 March 2019

19 September 2019

2 November 2019

13 November 2020

Novel molecular type of Clostridium difficile in neonatal pigs, Western Australia

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cites work

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Current application and future perspectives of molecular typing methods to study Clostridium difficile infections.

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Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing

6 September 2017

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C. difficile 630Δerm Spo0A regulates sporulation, but does not contribute to toxin production, by direct high-affinity binding to target DNA

6 September 2017

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The continually evolving Clostridium difficile species

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TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm

6 September 2017

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6 September 2017

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Clostridium difficile infection: toxins and non-toxin virulence factors, and their contributions to disease establishment and host response

6 September 2017

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Clostridium difficile infection in the community: a zoonotic disease?

6 September 2017

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Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations

6 September 2017

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Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts

6 September 2017

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The role of toxin A and toxin B in the virulence of Clostridium difficile

6 September 2017

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The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile

6 September 2017

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Reconsidering the sporulation characteristics of hypervirulent Clostridium difficile BI/NAP1/027.

6 September 2017

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Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

6 September 2017

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Binary toxin and death after Clostridium difficile infection

6 September 2017

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Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT).

6 September 2017

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Clostridium difficile infection in humans and animals, differences and similarities

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Clostridium difficile infection: An overview of the disease and its pathogenesis, epidemiology and interventions

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The role of toxin A and toxin B in Clostridium difficile infection

6 September 2017

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Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile

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The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives.

6 September 2017

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The changing epidemiology of Clostridium difficile infections

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The emergence of 'hypervirulence' in Clostridium difficile

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Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria

6 September 2017

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Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts

6 September 2017

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Clostridium difficile infection: new developments in epidemiology and pathogenesis

6 September 2017

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Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain

6 September 2017

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Clostridium difficile toxin synthesis is negatively regulated by TcdC.

6 September 2017

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Increased sporulation rate of epidemic Clostridium difficile Type 027/NAP1

6 September 2017

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Historical perspectives on studies of Clostridium difficile and C. difficile infection

6 September 2017

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Antimicrobial-associated risk factors for Clostridium difficile infection

6 September 2017

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Binary toxin production in Clostridium difficile is regulated by CdtR, a LytTR family response regulator

6 September 2017

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tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile

6 September 2017

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Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains

6 September 2017

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The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

6 September 2017

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Correlation of disease severity with fecal toxin levels in patients with Clostridium difficile-associated diarrhea and distribution of PCR ribotypes and toxin yields in vitro of corresponding isolates

6 September 2017

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An epidemic, toxin gene-variant strain of Clostridium difficile

6 September 2017

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A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality

6 September 2017

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A comparative genomic view of clostridial sporulation and physiology

6 September 2017

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Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec

6 September 2017

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Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile

6 September 2017

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Characterization of spo0A homologues in diverse Bacillus and Clostridium species identifies a probable DNA-binding domain

6 September 2017

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Antibiotic-Associated Pseudomembranous Colitis Due to Toxin-Producing Clostridia

6 September 2017

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Clostridium difficile using DNA microarrays

6 September 2017

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Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium

6 September 2017

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Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage

6 September 2017

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Multidrug resistance in European Clostridium difficile clinical isolates

6 September 2017

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Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts

14 September 2017

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Bacterial toxins that target Rho proteins

14 September 2017

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Diversity of cwp loci in clinical isolates of Clostridium difficile

14 September 2017

1 reference

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The Clostridium difficile spo0A gene is a persistence and transmission factor

23 June 2018

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TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing

23 June 2018

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Enhanced virulence of Salmonella enterica serovar typhimurium after passage through mice

23 June 2018

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23 June 2018

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Human Hypervirulent Clostridium difficile Strains Exhibit Increased Sporulation as Well as Robust Toxin Production

23 June 2018

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Fluoroquinolone resistance and Clostridium difficile, Germany

23 June 2018

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Effects of subinhibitory concentrations of antibiotics on colonization factor expression by moxifloxacin-susceptible and moxifloxacin-resistant Clostridium difficile strains

23 June 2018

1 reference

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Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production

23 June 2018

1 reference

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Clindamycin-induced colitis

23 June 2018

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Clostridium difficile infection caused by binary toxin-positive strains

23 June 2018

1 reference

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Two cases of fulminant colitis due to binary toxin-positive Clostridium difficile that are not PCR ribotype 027 or type 078.

31 August 2018

1 reference

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Surface-layer (S-layer) of human and animal Clostridium difficile strains and their behaviour in adherence to epithelial cells and intestinal colonization

31 August 2018

1 reference

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Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages

31 August 2018

1 reference

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Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production.

31 August 2018

1 reference

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Type-specific risk factors and outcome in an outbreak with 2 different Clostridium difficile types simultaneously in 1 hospital.

31 August 2018

1 reference

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Clostridium difficile PCR ribotype 176 in the Czech Republic and Poland.

31 August 2018

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TcdB or not TcdB: a tale of two Clostridium difficile toxins.

31 August 2018

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The diverse sporulation characteristics of Clostridium difficile clinical isolates are not associated with type

31 August 2018

1 reference

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Expression, purification and cell cytotoxicity of actin-modifying binary toxin from Clostridium difficile.

31 August 2018

1 reference

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Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078.

31 August 2018

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Emergence of reduced susceptibility to metronidazole in Clostridium difficile

31 August 2018

1 reference

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Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe

31 August 2018

1 reference

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Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters.

31 August 2018

1 reference

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A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use.

31 August 2018

1 reference

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INTESTINAL FLORA IN NEW-BORN INFANTS

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FVIRU.26297

Clostridium difficile infection in Europe: a hospital-based survey

21 January 2018

2 references

Crossref

https://api.crossref.org/works/10.4161%2FVIRU.26297

21 January 2018

12 December 2020

Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FVIRU.26297

Clinical features of Clostridium difficile-associated diarrhoea due to binary toxin (actin-specific ADP-ribosyltransferase)-producing strains

21 January 2018

1 reference

12 December 2020

Clostridium difficile toxin expression is inhibited by the novel regulator TcdC

1 reference

12 December 2020

Predicting recurrence of C. difficile colitis using bacterial virulence factors: binary toxin is the key

1 reference

12 December 2020

Comparison of toxin and spore production in clinically relevant strains of Clostridium difficile

1 reference

12 December 2020

Identifiers

DOI

10.4161/VIRU.26297

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

24060961

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24060961%20AND%20SRC:MED&resulttype=core&format=json