Mutational specificity of alkylating agents and the influence of DNA repair (Q38146054)

29 August 2017

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title

Mutational specificity of alkylating agents and the influence of DNA repair (English)

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29 August 2017

Horsfall MJ

1

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29 August 2017

Gordon AJ

2

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29 August 2017

Burns PA

3

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29 August 2017

Zielenska M

4

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29 August 2017

van der Vliet GM

5

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29 August 2017

Glickman BW

6

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29 August 2017

publication date

1 January 1990

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Environmental and Molecular Mutagenesis

29 August 2017

published in

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29 August 2017

volume

15

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29 August 2017

issue

2

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29 August 2017

page(s)

107-122

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DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

29 August 2017

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Isolation of a formamidopyrimidine-DNA glycosylase (fpg) mutant of Escherichia coli K12.

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7 January 2021

Influence of neighbouring base sequence on N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in the lacI gene of Escherichia coli.

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7 January 2021

Mutational specificity of N-methyl-N-nitrosourea in the lacI gene of Escherichia coli

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7 January 2021

uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174.

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7 January 2021

In vivo effect of DNA repair on the transition frequency produced from a single O6-methyl- or O6-n-butyl-guanine in a T:G base pair.

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7 January 2021

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

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7 January 2021

Empirical Predictions of Protein Conformation

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7 January 2021

Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli

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7 January 2021

Separation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesis

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7 January 2021

Abasic frameshift in DNA. Solution conformation determined by proton NMR and molecular mechanics calculations

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7 January 2021

Endonuclease IV (nfo) mutant of Escherichia coli

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7 January 2021

Effect of the adaptive response on the induction of the SOS pathway in E. coli K-12

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7 January 2021

Structure of a B-DNA dodecamer. II. Influence of base sequence on helix structure

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7 January 2021

Mutagenesis of bacteriophage T7 in vitro by incorporation of O6-methylguanine during DNA synthesis

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7 January 2021

Sequence specificity of guanine alkylation and repair.

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7 January 2021

The biochemistry of mutagenesis

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7 January 2021

Structure of a B-DNA dodecamer: conformation and dynamics

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7 January 2021

Estimation of apurinic/apyrimidinic sites and phosphotriesters in deoxyribonucleic acid treated with electrophilic carcinogens and mutagens.

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7 January 2021

Correlation of O4-ethyldeoxythymidine accumulation, hepatic initiation and hepatocellular carcinoma induction in rats continuously administered diethylnitrosamine.

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7 January 2021

Mechanism of mutagenesis by O6-methylguanine

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7 January 2021

Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea

1 reference

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7 January 2021

Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Adaptation to alkylation resistance involves the induction of a DNA glycosylase

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Sequence of the lacI gene

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation

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7 January 2021

Induction of transversion mutations in Escherichia coli by N-methyl-N'-nitro-N-nitrosoguanidine is SOS dependent

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7 January 2021

Loss of an apurinic/apyrimidinic site endonuclease increases the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine to Escherichia coli

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7 January 2021

Random components in mutagenesis

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7 January 2021

Mutagenicity of methyl-, ethyl-, propyl- and butylnitrosourea towards Escherichia coli WP2 strains with varying DNA repair capabilities

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7 January 2021

Induced mutagenesis in dam − mutants of Escherichia coli: A role for 6-methyladenine residues in mutation avoidance

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7 January 2021

Nearest neighbor affects G:C to A:T transitions induced by alkylating agents

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Protein domain structure influences observed distribution of mutation

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7 January 2021

Missense mutation in the lacI gene of Escherichia coli. Inferences on the structure of the repressor protein

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7 January 2021

N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation in a RecA strain of Escherichia coli

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7 January 2021

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

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7 January 2021

Repair of O6-methylguanine, O6-ethylguanine, O6-isopropylguanine and O4-methylthymine in synthetic oligodeoxynucleotides by Escherichia coli ada gene O6-alkylguanine-DNA-alkyltransferase

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Site-specific mutagenesis in vivo by single methylated or deaminated purine bases

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Mutation site specificity of N-nitroso-N-methyl-N-alpha-acetoxybenzylamine: a model derivative of an esophageal carcinogen

1 reference

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7 January 2021

Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli. I. The direct-acting analogue N-nitroso-N-methyl-N-alpha-acetoxymethylamine

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7 January 2021

Mutational specificities of environmental carcinogens in the lacl gene of Escherichia coli. II: A host-mediated approach to N-nitroso-N,N-dimethylamine and endogenous mutagenesis in vivo

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7 January 2021

Evidence for a major premutagenic ethyldeoxythymidine-DNA adduct in an in vivo system: N-nitroso-N-ethylurea-treated Salmonella typhimurium.

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7 January 2021

An inducible DNA replication–cell division coupling mechanism in E. coli

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7 January 2021

Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro.

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7 January 2021

Mutational specificities of 1'-acetoxysafrole, N-benzoyloxy-N-methyl-4-aminoazobenzene, and ethyl methanesulfonate in human cells

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7 January 2021

Comparative analysis of deletion and base-change mutabilities of Escherichia coli B strains differing in DNA repair capacity (Wild-type, uvra-, pola-, reca-) by various mutagens

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7 January 2021

An adaptive response of E. coli to low levels of alkylating agent: Comparison with previously characterised DNA repair pathways

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7 January 2021

N-Methyl-N'-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair

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7 January 2021

Amplified expression of the tag+ and alkA+ genes in Escherichia coli: identification of gene products and effects on alkylation resistance

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7 January 2021

Base pair mismatches and carcinogen-modified bases in DNA: an NMR study of G.T and G.O4meT pairing in dodecanucleotide duplexes

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7 January 2021

Mismatch correction at O 6 -methylguanine residues in E. coli DNA

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7 January 2021

Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase

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7 January 2021

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

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7 January 2021

Role of neighbouring bases and assessment of strand specificity in ethylmethanesulphonate and N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in the SUP4-o gene of Saccharomyces cerevisiae

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7 January 2021

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards

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7 January 2021

Mutational specificity of depurination

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7 January 2021

Depurination-induced infidelity of deoxyribonucleic acid synthesis with purified deoxyribonucleic acid replication proteins in vitro

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7 January 2021

Mechanism of mutation by thymine starvation in Escherichia coli: clues from mutagenic specificity

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7 January 2021

Methylation-induced blocks to in vitro DNA replication

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7 January 2021

Some chemical aspects of dose-response relationships in alkylation mutagenesis

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7 January 2021

Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group.

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7 January 2021

Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea

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7 January 2021

Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase

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7 January 2021

Regulation and expression of the adaptive response to alkylating agents

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7 January 2021

Apurinic sites as mutagenic intermediates

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7 January 2021

Fidelity of DNA synthesis

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7 January 2021

Mutagenesis by apurinic/apyrimidinic sites

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7 January 2021

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome

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7 January 2021

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

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7 January 2021

Analysis of forward mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the bacteriophage P22 mnt repressor gene

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7 January 2021

Response of S. cerevisiae to N-methyl-N'-nitro-N-nitrosoguanidine: mutagenesis, survival and DDR gene expression

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7 January 2021

DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards

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7 January 2021

Mutational specificity in bacteria

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7 January 2021

Specificity of mutagenesis resulting from the induction of the SOS system in the absence of mutagenic treatment

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7 January 2021

Correlation of nonsense sites in the lacI gene with specific codons in the nucleotide sequence.

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7 January 2021

Reaction of 1-n-propyl-1-nitrosourea with DNA in vitro

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7 January 2021

Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli

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7 January 2021

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

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7 January 2021

Ring-opened 7-methylguanine residues in DNA are a block to in vitro DNA synthesis

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7 January 2021

Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites

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7 January 2021

An optimized potential function for the calculation of nucleic acid interaction energies I. base stacking

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7 January 2021

Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion

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7 January 2021

Conformation of O6-alkylguanosines: molecular mechanism of mutagenesis.

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7 January 2021

Covalent carcinogenic lesions in DNA: NMR studies of O6-methylguanosine containing oligonucleotide duplexes

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7 January 2021

Structural studies of the O6meG.T interaction in the d(C-G-T-G-A-A-T-T-C-O6meG-C-G) duplex

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7 January 2021

A theoretical study of the effect of methylation or ethylation at O6-guanine in the structure and energy of DNA double strands.

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7 January 2021

Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.

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7 January 2021

Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli

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7 January 2021

Mutagenic specificity: reversion of iso-1-cytochrome c mutants of yeast

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7 January 2021

Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis

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7 January 2021

Molecular electrostatic potential of the nucleic acids

1 reference

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7 January 2021

In vitro bypass of UV-induced lesions by Escherichia coli DNA polymerase I: specificity of nucleotide incorporation.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Mismatch repair in Escherichia coli

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

A second DNA methyltransferase repair enzyme in Escherichia coli

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Effect of the direction of DNA replication on mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine in adapted cells of Escherichia coli

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Properties of 3-methyladenine-DNA glycosylase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Differential repair of O4-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

DNA base changes induced following in vivo exposure of unadapted, adapted or ada- Escherichia coli to N-methyl-N'-nitro-N-nitrosoguanidine

1 reference

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7 January 2021

DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea

1 reference

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7 January 2021

Mutation spectra of N-ethyl-N'-nitro-N-nitrosoguanidine and 1-(2-hydroxyethyl)-1-nitrosourea in Escherichia coli

1 reference

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7 January 2021

Excision repair of O6-methylguanine synthesized at the rat H-ras N-methyl-N-nitrosourea activation site and introduced into Escherichia coli.

1 reference

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7 January 2021

In vitro reaction of N-n-butyl-N-nitrosourea and n-butyl methanesulphonate with guanine and thymine bases of DNA

1 reference

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7 January 2021

Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Signal of induction of rec A protein in E. coli

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

A new pathway for DNA repair in Escherichia coli

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7 January 2021

https://api.crossref.org/works/10.1002%2FEM.2850150208

1 reference

7 January 2021

Origin of DNA helical structure and its sequence dependence

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Depurination causes mutations in SOS-induced cells.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Infidelity of DNA synthesis associated with bypass of apurinic sites

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Mechanisms of spontaneous mutagenesis: an analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene.

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Repair of O6-methylguanine in adapted Escherichia coli

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

The role of umuC gene product in mutagenesis by simple alkylating agents

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7 January 2021

Construction of an Escherichia coli K-12 ada deletion by gene replacement in a recD strain reveals a second methyltransferase that repairs alkylated DNA

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7 January 2021

https://api.crossref.org/works/10.1002%2FEM.2850150208

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7 January 2021

Do carcinogen-modified deoxynucleotide precursors contribute to cellular mutagenesis?

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

DNA base modification: ionized base pairs and mutagenesis

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https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

O4-ethyldeoxythymidine, but not O6-ethyldeoxyguanosine, accumulates in hepatocyte DNA of rats exposed continuously to diethylnitrosamine

1 reference

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7 January 2021

Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine

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7 January 2021

DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

The complexity of nitrosoguanidine mutagenesis increases with size: observations of the mutational specificity of N-propyl-N'-nitro-N-nitrosoguanidine.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage by ABC excinuclease.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Inhibition of the SOS response of Escherichia coli by the Ada protein

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Adaptive response of Escherichia coli to alkylation damage

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Altered induction of the adaptive response to alkylation damage in Escherichia coli recF mutants

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Expression of DNA damage-inducible genes of Escherichia coli upon treatment with methylating, ethylating and propylating agents

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Inequality in mutation rates of the two strands of DNA.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

The effect of DNA sequence, ionic strength, and cationic DNA affinity binders on the methylation of DNA by N-methyl-N-nitrosourea

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Differential mutagenicities of 6 N-nitroso-N-alkylurea derivatives in Escherichia coli strains with different DNA-repair capacities

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Different mutational profiles induced by N-nitroso-N-ethylurea: effects of dose and error-prone DNA repair and correlations with DNA adducts.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850150208

7 January 2021

Identifiers

DOI

10.1002/EM.2850150208

1 reference

29 August 2017

1 reference