Applying insights from biofilm biology to drug development - can a new approach be developed? (Q38147863)

29 August 2017

Applying insights from biofilm biology to drug development - can a new approach be developed? (English)

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29 August 2017

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3

Søren Molin

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Niels Høiby

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5

object named as

Niels Høiby

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Oana Ciofu

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2

object named as

Oana Ciofu

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Thomas Bjarnsholt

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1

object named as

Thomas Bjarnsholt

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29 August 2017

Michael Givskov

4

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publication date

1 October 2013

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Nature Reviews Drug Discovery

29 August 2017

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29 August 2017

12

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29 August 2017

791-808

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29 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd4000

29 August 2017

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Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

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Why chronic wounds will not heal: a novel hypothesis

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Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients.

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Azithromycin exhibits bactericidal effects on Pseudomonas aeruginosa through interaction with the outer membrane

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Azithromycin retards Pseudomonas aeruginosa biofilm formation

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31 March 2020

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The interconnection between biofilm formation and horizontal gene transfer

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

31 March 2020

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Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants

31 March 2020

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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

31 March 2020

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The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling

31 March 2020

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A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels

31 March 2020

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Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa

31 March 2020

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Two-component regulatory systems in Pseudomonas aeruginosa: an intricate network mediating fimbrial and efflux pump gene expression

31 March 2020

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Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

31 March 2020

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Pseudomonas aeruginosa cupA-encoded fimbriae expression is regulated by a GGDEF and EAL domain-dependent modulation of the intracellular level of cyclic diguanylate

31 March 2020

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SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation

31 March 2020

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Iron and Pseudomonas aeruginosa biofilm formation.

31 March 2020

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Targeting iron uptake to control Pseudomonas aeruginosa infections in cystic fibrosis.

31 March 2020

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Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

31 March 2020

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Aminoglycoside antibiotics induce bacterial biofilm formation

31 March 2020

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The implication of Pseudomonas aeruginosa biofilms in infections

31 March 2020

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Chemical communication among bacteria.

31 March 2020

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Quorum-sensing regulators control virulence gene expression in Vibrio cholerae

31 March 2020

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Microbiology of airway disease in patients with cystic fibrosis

31 March 2020

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Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa

31 March 2020

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Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens.

31 March 2020

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Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili

31 March 2020

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The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility

31 March 2020

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Biochemical and genetic characterization of a competence pheromone from B. subtilis

31 March 2020

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Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence

31 March 2020

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Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

31 March 2020

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The Nonsteroidal Antiinflammatory Drug Diclofenac Potentiates the In Vivo Activity of Caspofungin Against Candida albicans Biofilms

31 March 2020

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Bacterial biofilms: a common cause of persistent infections

31 March 2020

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Bacterial biofilms in nature and disease

31 March 2020

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Importance of DNase and alginate lyase for enhancing free and liposome encapsulated aminoglycoside activity against Pseudomonas aeruginosa

31 March 2020

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Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosa

31 March 2020

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Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms.

31 March 2020

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Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions.

31 March 2020

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Arginine or nitrate enhances antibiotic susceptibility of Pseudomonas aeruginosa in biofilms

31 March 2020

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Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

31 March 2020

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Mathematical model of beta-lactam penetration into a biofilm of Pseudomonas aeruginosa while undergoing simultaneous inactivation by released beta-lactamases.

31 March 2020

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Dynamics and spatial distribution of beta-lactamase expression in Pseudomonas aeruginosa biofilms

31 March 2020

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Molecular basis of azithromycin-resistant Pseudomonas aeruginosa biofilms

31 March 2020

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The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

31 March 2020

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Bacterial stress responses as determinants of antimicrobial resistance

31 March 2020

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Inactivation of efflux pumps abolishes bacterial biofilm formation

31 March 2020

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Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation

31 March 2020

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High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms

31 March 2020

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Increased mutability of Pseudomonas aeruginosa in biofilms

31 March 2020

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Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation

31 March 2020

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Gene expression and protein levels of the stationary phase sigma factor, RpoS, in continuously-fed Pseudomonas aeruginosa biofilms

31 March 2020

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Stress-induced mutagenesis in bacteria

31 March 2020

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31 March 2020

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Dynamics of mutator and antibiotic-resistant populations in a pharmacokinetic/pharmacodynamic model of Pseudomonas aeruginosa biofilm treatment.

31 March 2020

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Endogenous oxidative stress produces diversity and adaptability in biofilm communities

31 March 2020

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A common mechanism of cellular death induced by bactericidal antibiotics

31 March 2020

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31 March 2020

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Infection risk with nitrofurazone-impregnated urinary catheters in trauma patients: a randomized trial.

31 March 2020

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31 March 2020

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Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial

31 March 2020

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Antimicrobial activity of gentamicin palmitate against high concentrations of Staphylococcus aureus

31 March 2020

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Are Antimicrobial-Impregnated Catheters Effective? When Does Repetition Reach the Point of Exhaustion?

31 March 2020

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Prophylactic efficacy of a new gentamicin-releasing urethral catheter in short-term catheterized rabbits

31 March 2020

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Evaluation of the antimicrobial efficacy of urinary catheters impregnated with antiseptics in an in vitro urinary tract model

31 March 2020

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Systematic review: antimicrobial urinary catheters to prevent catheter-associated urinary tract infection in hospitalized patients

31 March 2020

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New strategies to prevent catheter-associated urinary tract infections

31 March 2020

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Antimicrobial catheters for reduction of symptomatic urinary tract infection in adults requiring short-term catheterisation in hospital: a multicentre randomised controlled trial.

31 March 2020

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Antibacterial surfaces for biomedical devices.

31 March 2020

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A UVC device for intra-luminal disinfection of catheters: in vitro tests on soft polymer tubes contaminated with Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Candida albicans

31 March 2020

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Effects of photoactivated titanium dioxide nanopowders and coating on planktonic and biofilm growth of Pseudomonas aeruginosa.

31 March 2020

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Resolution of Staphylococcus aureus biofilm infection using vaccination and antibiotic treatment

31 March 2020

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A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients

31 March 2020

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Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients

31 March 2020

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Effect of aerosolized rhDNase (Pulmozyme) on pulmonary colonization in patients with cystic fibrosis

31 March 2020

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Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

31 March 2020

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Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

31 March 2020

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Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa

31 March 2020

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Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo

31 March 2020

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Pathogenicity of staphylococci; a comparison of alpha-hemolysin production with the coagulase test and clinical observations of virulence

31 March 2020

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Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

31 March 2020

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Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

31 March 2020

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Antibodies against beta-lactamase can improve ceftazidime treatment of lung infection with beta-lactam-resistant Pseudomonas aeruginosa in a rat model of chronic lung infection.

31 March 2020

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Antibodies against Pseudomonas aeruginosa chromosomal beta-lactamase inpatients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to beta-lactams

31 March 2020

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Avidity of anti-P aeruginosa antibodies during chronic infection in patients with cystic fibrosis

31 March 2020

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Quorum sensing inhibitory drugs as next generation antimicrobials: worth the effort?

31 March 2020

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Agr-mediated dispersal of Staphylococcus aureus biofilms

31 March 2020

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In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

31 March 2020

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Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice

31 March 2020

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Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.

31 March 2020

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Quorum sensing antagonism from marine organisms

31 March 2020

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Quorum-sensing inhibitors as anti-pathogenic drugs

31 March 2020

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Identity and effects of quorum-sensing inhibitors produced by Penicillium species.

31 March 2020

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Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector

31 March 2020

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Controlling infection by tuning in and turning down the volume of bacterial small-talk

31 March 2020

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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

31 March 2020

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Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

31 March 2020

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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

31 March 2020

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Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

31 March 2020

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Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

31 March 2020

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Antimicrobial properties of allicin from garlic

31 March 2020

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Panax ginseng has anti-infective activity against opportunistic pathogen Pseudomonas aeruginosa by inhibiting quorum sensing, a bacterial communication process critical for establishing infection

31 March 2020

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Effects of ginseng onPseudomonas aeruginosamotility and biofilm formation

31 March 2020

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Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer

31 March 2020

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Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

31 March 2020

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Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patients

31 March 2020

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Influence of quorum sensing and iron on twitching motility and biofilm formation in Pseudomonas aeruginosa.

31 March 2020

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Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm.

31 March 2020

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Siderophore-antibiotic conjugates used as trojan horses against Pseudomonas aeruginosa

31 March 2020

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Iron transport-mediated drug delivery using mixed-ligand siderophore-β-lactam conjugates

31 March 2020

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Iron chelation directed against biofilms as an adjunct to conventional antibiotics

31 March 2020

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Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells

31 March 2020

1 reference

The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent.

31 March 2020

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The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity

31 March 2020

1 reference

Small RNA gene identification and mRNA target predictions in bacteria

31 March 2020

1 reference

The small regulatory RNA molecule MicA is involved in Salmonella enterica serovar Typhimurium biofilm formation

31 March 2020

1 reference

Hacking into bacterial biofilms: a new therapeutic challenge

31 March 2020

1 reference

Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants.

31 March 2020

1 reference

Bacterial colonization and infection of electrophysiological cardiac devices detected with sonication and swab culture

31 March 2020

1 reference

A biofilm approach to detect bacteria on removed spinal implants

31 March 2020

1 reference

Sonication is superior to scraping for retrieval of bacteria in biofilm on titanium and steel surfaces in vitro

31 March 2020

1 reference

Therapeutic ultrasound as treatment for chronic rhinosinusitis: preliminary observations.

31 March 2020

1 reference

Efficacy of the lithotripsy in treating lower pole renal stones.

31 March 2020

1 reference

Therapeutic potential of biofilm-dispersing enzymes.

31 March 2020

1 reference

Alginate lyase enhances antibiotic killing of mucoid Pseudomonas aeruginosa in biofilms

31 March 2020

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Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm

31 March 2020

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A fatty acid messenger is responsible for inducing dispersion in microbial biofilms

31 March 2020

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Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa

31 March 2020

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Proteins with GGDEF and EAL domains regulate Pseudomonas putida biofilm formation and dispersal.

31 March 2020

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Engineering a novel c-di-GMP-binding protein for biofilm dispersal.

31 March 2020

1 reference

Monitoring of diguanylate cyclase activity and of cyclic-di-GMP biosynthesis by whole-cell assays suitable for high-throughput screening of biofilm inhibitors

31 March 2020

1 reference

Inhaled medication and inhalation devices for lung disease in patients with cystic fibrosis: A European consensus

31 March 2020

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Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America

31 March 2020

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Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: results from a prospective trial.

31 March 2020

1 reference

Role of hydrochloric acid in the treatment of central venous catheter infections in children with cancer.

31 March 2020

1 reference

Antibiotic susceptabilities of Pseudomonas aeruginosa isolates derived from patients with cystic fibrosis under aerobic, anaerobic, and biofilm conditions.

31 March 2020

1 reference

Ribosome protection prevents azithromycin-mediated quorum-sensing modulation and stationary-phase killing of Pseudomonas aeruginosa

31 March 2020

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Heterogeneous bacterial persisters and engineering approaches to eliminate them

31 March 2020

1 reference

Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A.

31 March 2020

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Prostaglandin production during growth of Candida albicans biofilms

31 March 2020

1 reference

Effects of aspirin and other nonsteroidal anti-inflammatory drugs on biofilms and planktonic cells of Candida albicans

31 March 2020

1 reference

The role of diclofenac sodium in the dimorphic transition in Candida albicans

31 March 2020

1 reference

Bacterial efflux systems and efflux pumps inhibitors

31 March 2020

1 reference

Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation

31 March 2020

1 reference

High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis

31 March 2020

1 reference

Biofilm susceptibility to bacteriophage attack: the role of phage-borne polysaccharide depolymerase

31 March 2020

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Cell death in Pseudomonas aeruginosa biofilm development.

31 March 2020

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Pulmonary bacteriophage therapy on Pseudomonas aeruginosa cystic fibrosis strains: first steps towards treatment and prevention

31 March 2020

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Bacteriophages φMR299-2 and φNH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells

31 March 2020

1 reference

Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials

31 March 2020

1 reference

Bacteriophage cocktail for the prevention of biofilm formation by Pseudomonas aeruginosa on catheters in an in vitro model system.

31 March 2020

1 reference

In vitro destruction of Streptococcus pneumoniae biofilms with bacterial and phage peptidoglycan hydrolases

31 March 2020

1 reference

Application of a bacteriophage lysin to disrupt biofilms formed by the animal pathogen Streptococcus suis

31 March 2020

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Bacteriophages as vehicles of the resistome in cystic fibrosis.

31 March 2020

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Metagenomic analysis of respiratory tract DNA viral communities in cystic fibrosis and non-cystic fibrosis individuals

31 March 2020

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The role of regulated clinical trials in the development of bacteriophage therapeutics

31 March 2020

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A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa ; a preliminary report of efficacy

31 March 2020

1 reference

Pseudomonas biofilms, cystic fibrosis, and phage: a silver lining?

31 March 2020

1 reference

Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice

31 March 2020

1 reference

Effects of intratracheal administration of novispirin G10 on a rat model of mucoid Pseudomonas aeruginosa lung infection

31 March 2020

1 reference

Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in a mouse peritonitis model

31 March 2020

1 reference

Drugs for bad bugs: confronting the challenges of antibacterial discovery

31 March 2020

1 reference

Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.

31 March 2020

1 reference

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

31 March 2020

1 reference

Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis

31 March 2020

1 reference

Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin

31 March 2020

1 reference

A method for growing a biofilm under low shear at the air-liquid interface using the drip flow biofilm reactor

31 March 2020

1 reference

Measuring antimicrobial effects on biofilm bacteria: from laboratory to field

31 March 2020

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An in vitro model of bacterial infections in wounds and other soft tissues

31 March 2020

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Growing and analyzing static biofilms

31 March 2020

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Distribution, organization, and ecology of bacteria in chronic wounds

31 March 2020

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Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control

31 March 2020

1 reference

Effect of the growth rate of Pseudomonas aeruginosa biofilms on the susceptibility to antimicrobial agents: beta-lactams and fluoroquinolones

31 March 2020

1 reference

Involvement of a novel efflux system in biofilm-specific resistance to antibiotics

31 March 2020

1 reference

Establishment of aging biofilms: possible mechanism of bacterial resistance to antimicrobial therapy

31 March 2020

1 reference

Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms

31 March 2020

1 reference

MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa to aminoglycosides.

31 March 2020

1 reference

A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance

31 March 2020

1 reference

Experimental and clinical studies on the release of gentamicin from bone cement

31 March 2020

1 reference

12 December 2020

Development of antibiotic resistance in Pseudomonas aeruginosa during two decades of antipseudomonal treatment at the Danish CF Center.

1 reference

12 December 2020

Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. A survey

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12 December 2020

Comparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa bofilms displaying rapid-transport characteristics

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12 December 2020

High rates of conjugation in bacterial biofilms as determined by quantitative in situ analysis

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12 December 2020

Tolerance of dormant and active cells in Pseudomonas aeruginosa PA01 biofilm to antimicrobial agents

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12 December 2020

The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms.

1 reference

12 December 2020

Scanning and transmission electron microscopy of in situ bacterial colonization of intravenous and intraarterial catheters.

1 reference

12 December 2020

Theoretical aspects of antibiotic diffusion into microbial biofilms

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12 December 2020

Pseudomonas aeruginosa chromosomal beta-lactamase in patients with cystic fibrosis and chronic lung infection. Mechanism of antibiotic resistance and target of the humoral immune response.

1 reference

12 December 2020

Surface motility of serratia liquefaciens MG1

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12 December 2020

Resistance development of bacterial biofilms against bacteriophage attack

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12 December 2020

Morphology of Pseudomonas aeruginosa phages from the sputum of cystic fibrosis patients and from the phage typing set. An electron microscopy study

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12 December 2020

Antibacterial activity of antibiotic coated silicone grafts

1 reference

12 December 2020

Brief ultrasonication improves detection of biofilm-formative bacteria around a metal implant.

1 reference

12 December 2020

The ArgR regulatory protein, a helper to the anaerobic regulator ANR during transcriptional activation of the arcD promoter in Pseudomonas aeruginosa

1 reference

12 December 2020

Biomaterial-centered infection: microbial adhesion versus tissue integration. 1987.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD4000

1 reference

PubMed ID

24080700

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

24080700