The psymberin story--biological properties and approaches towards total and analogue syntheses (Q38150788)

29 August 2017

The psymberin story--biological properties and approaches towards total and analogue syntheses (English)

1 reference

29 August 2017

2

Jörg Pietruszka

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29 August 2017

Max Bielitza

1

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PubMed ID

24105772

29 August 2017

language of work or name

English

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publication date

17 September 2013

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Angewandte Chemie International Edition

29 August 2017

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volume

52

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29 August 2017

42

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29 August 2017

10960-10985

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4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

29 August 2017

1 reference

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Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

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Insights from the sea: structural biology of marine polyketide synthases

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Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family

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Paederus, sensu lato (Coleoptera: Staphylinidae): natural history and medical importance

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Rove beetle blistering--(Nairobi Eye).

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Paederus dermatitis in northern Iran: a report of 156 cases

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Blister beetles and the ten plagues

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Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products

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Mycalamides, pederin and psymberin as natural carbohydrates and potential antitumor agents: past and future perspectives.

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Total synthesis of pederin and analogues

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A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

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Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles

21 January 2018

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Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa.

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Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

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Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta

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Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina

21 January 2018

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Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians.

21 January 2018

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Change of ras-Transformed NRK-Cells Back to Normal Morphology by Mycalamides A and B, Antitumor Agents from a Marine Sponge

21 January 2018

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Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine.

21 January 2018

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Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products

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13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit

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Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.

21 January 2018

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Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs

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Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin

21 January 2018

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The Complete Structure of Maitotoxin, Part I: Configuration of the C1C14 Side Chain

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Total synthesis of (+)-psymberin (irciniastatin A): catalytic reagent control as the strategic cornerstone

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Highly enantioselective inverse-electron-demand hetero-diels-alder reactions of alpha,beta-unsaturated aldehydes.

21 January 2018

1 reference

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Progress toward the total synthesis of psymberin/irciniastatin A.

21 January 2018

1 reference

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Total synthesis of irciniastatin A (Psymberin).

21 January 2018

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Stereoselective synthesis of 2,6-trans-tetrahydropyran via primary diamine-catalyzed oxa-conjugate addition reaction of α,β-unsaturated ketone: total synthesis of psymberin.

21 January 2018

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Studies toward the unique pederin family member psymberin: full structure elucidation, two alternative total syntheses, and analogs

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Iridium-catalyzed oxidative lactonization and intramolecular Tishchenko reaction of delta-ketoaldehydes for the synthesis of isocoumarins and 3,4-dihydroisocoumarins

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Efficient and flexible synthesis of chiral gamma- and delta-lactones

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Enantioselective synthesis of spirocyclic benzopyranones by rhodium-catalyzed intermolecular [4+2] annulation

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Stereochemical assignment of the C1-C6 fragment of psymberin by synthesis and natural product degradation.

21 January 2018

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Two-step synthesis of carbohydrates by selective aldol reactions

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Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates

21 January 2018

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Multicomponent approach to the synthesis of oxidized amides through nitrile hydrozirconation

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Multicomponent synthesis of alpha-branched amides

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Stereoselective synthesis of spirooxindole amides through nitrile hydrozirconation

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Total synthesis of (-)-irciniastatin B and structural confirmation via chemical conversion to (+)-irciniastatin A (psymberin)

21 January 2018

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Total synthesis of (+)-irciniastatin A (a.k.a. psymberin) and (-)-irciniastatin B

21 January 2018

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Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products

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The discovery of potent antitumor agent C11-deoxypsymberin/irciniastatin A: total synthesis and biology of advanced psymberin analogs.

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Antineoplastic agents. 257. Isolation and structure of spongistatin 1

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Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.

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Isolation and structure of bryostatin 1

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Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to α-hydroxyacid and amide derivatives

21 January 2018

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Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides

21 January 2018

1 reference

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Synthesis of 8-Desmethoxy Psymberin: A Putative Biosynthetic Intermediate Towards the Marine Polyketide Psymberin

21 January 2018

1 reference

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Chemoenzymatic Synthesis of (Protected) Psymberic Acid

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201301259

1 reference

release_sfla5lfvjfgpjajgqqelotxxy4

29 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sfla5lfvjfgpjajgqqelotxxy4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

24105772

1 reference

PubMed ID

24105772