Implications of intratumour heterogeneity for treatment stratification (Q38151633)

29 August 2017

Implications of intratumour heterogeneity for treatment stratification (English)

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29 August 2017

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Charles Swanton

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author name string

Andrew Crockford

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1

1 reference

PubMed ID

24115146

29 August 2017

Mariam Jamal-Hanjani

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2

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PubMed ID

24115146

29 August 2017

James Hicks

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3

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29 August 2017

1 January 2014

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29 August 2017

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264-273

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Strategies for optimizing combinations of molecularly targeted anticancer agents

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1 reference

Analysis of anticancer drugs: a review.

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The Pathology of Tumors, Part III: Grading, Staging & Classification

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Origins of ... tinctorial methods in histology

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Metastatic variants are generated spontaneously at a high rate in mouse KHT tumor

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

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The clonal evolution of tumor cell populations

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Cancer chromosomal instability: therapeutic and diagnostic challenges

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1 reference

Replication stress links structural and numerical cancer chromosomal instability

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1 reference

Deciphering signatures of mutational processes operative in human cancer

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Genetic variegation of clonal architecture and propagating cells in leukaemia

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

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Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

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1 reference

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

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Parallel evolution of tumour subclones mimics diversity between tumours

21 January 2018

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Intratumor heterogeneity: seeing the wood for the trees.

21 January 2018

1 reference

Breast cancer genome heterogeneity: a challenge to personalised medicine?

21 January 2018

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Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas

21 January 2018

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Targeted therapies for breast cancer

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The Clinical Importance of the Heterogeneity of HER2 neu.

21 January 2018

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Intratumoral heterogeneity of HER2/neu expression and its consequences for the management of advanced breast cancer

21 January 2018

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Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer

21 January 2018

1 reference

Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with esophageal adenocarcinoma

21 January 2018

1 reference

Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance

21 January 2018

1 reference

Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors

21 January 2018

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Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression.

21 January 2018

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Common protein biomarkers assessed by reverse phase protein arrays show considerable intratumoral heterogeneity in breast cancer tissues

21 January 2018

1 reference

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas.

21 January 2018

1 reference

HER2 testing in gastric cancer: a practical approach

21 January 2018

1 reference

Clinical significance of intratumoral HER2 heterogeneity in gastric cancer

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1 reference

Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

21 January 2018

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Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

21 January 2018

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Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma.

21 January 2018

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Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib--a phase II trial

21 January 2018

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

21 January 2018

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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.

21 January 2018

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Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

21 January 2018

1 reference

Comparative genomic analysis of primary versus metastatic colorectal carcinomas.

21 January 2018

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Estrogen and HER-2 receptor discordance between primary breast cancer and metastasis

21 January 2018

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A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia.

21 January 2018

1 reference

Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer.

21 January 2018

1 reference

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib

21 January 2018

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EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas.

21 January 2018

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Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma

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1 reference

ALK translocation and crizotinib in non-small cell lung cancer: an evolving paradigm in oncology drug development

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EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

21 January 2018

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21 January 2018

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

21 January 2018

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The tumor microenvironment and its role in promoting tumor growth

21 January 2018

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Drug resistance and the solid tumor microenvironment

21 January 2018

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

21 January 2018

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The promise of patient-derived xenografts: the best laid plans of mice and men

21 January 2018

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Characterization of two novel cell lines with distinct heterogeneity derived from a single human bile duct carcinoma

21 January 2018

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Patient-derived tumour xenografts as models for oncology drug development

21 January 2018

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A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro

21 January 2018

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Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability.

21 January 2018

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Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer

21 January 2018

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Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas.

21 January 2018

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A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer

21 January 2018

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Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer

21 January 2018

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Immune microenvironments in solid tumors: new targets for therapy

21 January 2018

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Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells

21 January 2018

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Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy

21 January 2018

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Genome remodelling in a basal-like breast cancer metastasis and xenograft

21 January 2018

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Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines

21 January 2018

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Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer.

21 January 2018

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Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells

21 January 2018

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Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer

21 January 2018

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Genomic profiling of isolated circulating tumor cells from metastatic breast cancer patients

21 January 2018

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Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing

21 January 2018

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Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing

21 January 2018

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RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

21 January 2018

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Fluid biopsy for solid tumors: a patient's companion for lifelong characterization of their disease

21 January 2018

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Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets

21 January 2018

1 reference

Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4270

1 reference

29 August 2017

1 reference

PubMed ID

24115146