Lymphatic vessels: new targets for the treatment of inflammatory diseases (Q38161374)

30 August 2017

Lymphatic vessels: new targets for the treatment of inflammatory diseases (English)

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30 August 2017

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3

Michael Detmar

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30 August 2017

Lothar C Dieterich

1

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PubMed ID

24212981

30 August 2017

Catharina D Seidel

series ordinal

2

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30 August 2017

9 November 2013

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30 August 2017

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30 August 2017

17

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30 August 2017

2

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30 August 2017

359-371

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https://scigraph.springernature.com/pub.10.1007/s10456-013-9406-1

30 August 2017

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cites work

Molecular mechanisms of lymphangiogenesis in development and cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

The lymphatic vasculature in disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

New insights into the molecular control of the lymphatic vascular system and its role in disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Chapter 1. Inflammation, angiogenesis, and lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymphangiogenesis: Molecular mechanisms and future promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Prox1 expression patterns in the developing and adult murine brain.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Novel expression and characterization of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1) by conjunctival cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphang

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

T1 alpha protein is developmentally regulated and expressed by alveolar type I cells, choroid plexus, and ciliary epithelia of adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

The expression of podoplanin and classic cadherins in the mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Role of CD30 in B/T segregation in the spleen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Markers for microscopic imaging of lymphangiogenesis and angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

An important role of lymphatic vessel activation in limiting acute inflammation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Increased lymphangiogenesis in joints of mice with inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Distribution of lymphatic vessels in normal and arthritic human synovial tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Inflammation-driven dermal lymphangiogenesis in atopic dermatitis is associated with CD11b+ macrophage recruitment and VEGF-C up-regulation in the IL-4-transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Emerging roles of lymphatics in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Inflammation-induced lymph node lymphangiogenesis is reversible

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Dose-dependent response of FGF-2 for lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Hepatocyte growth factor promotes lymphatic vessel formation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Differential cytokine responses in human and mouse lymphatic endothelial cells to cytokines in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymphatic endothelial cells - key players in regulation of tolerance and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Expansion of cortical and medullary sinuses restrains lymph node hypertrophy during prolonged inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Regulation of T cell priming by lymphoid stroma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Interaction of tumor cells and lymphatic vessels in cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Therapeutic lymphangiogenesis with implantation of adipose-derived regenerative cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Glucocorticoids suppress corneal lymphangiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Efficacy of topical blockade of interleukin-1 in experimental dry eye disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Role of interleukin-17 in lymphangiogenesis in non-small-cell lung cancer: Enhanced production of vascular endothelial growth factor C in non-small-cell lung carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

A novel pro-lymphangiogenic function for Th17/IL-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

A Novel Gene Expression Profile in Lymphatics Associated with Tumor Growth and Nodal Metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10456-013-9406-1

10.1007/S10456-013-9406-1

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24212981