µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain (Q38162871)

30 August 2017

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µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain (English)

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30 August 2017

Jörn Lötsch

4

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author name string

Carmen Walter

series ordinal

1

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30 August 2017

Alexandra Doehring

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2

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30 August 2017

Bruno G Oertel

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3

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30 August 2017

publication date

1 November 2013

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30 August 2017

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30 August 2017

volume

14

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30 August 2017

issue

15

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30 August 2017

page(s)

1915-1925

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Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

30 August 2017

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Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor

21 January 2018

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A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain

21 January 2018

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Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction

21 January 2018

1 reference

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Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human micro-opioid receptors (hMORs) containing the A118G single-nucleotide polymorphism

21 January 2018

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A118G Mu Opioid Receptor polymorphism increases inhibitory effects on CaV2.2 channels

21 January 2018

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Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

21 January 2018

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Genetic-epigenetic interaction modulates μ-opioid receptor regulation

21 January 2018

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Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

21 January 2018

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Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.

21 January 2018

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Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior

21 January 2018

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A genetic determinant of the striatal dopamine response to alcohol in men

21 January 2018

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Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons

21 January 2018

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A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling

21 January 2018

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The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans

21 January 2018

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The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation

21 January 2018

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Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients

21 January 2018

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Differential opioid action on sensory and affective cerebral pain processing

21 January 2018

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Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?

21 January 2018

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The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers

21 January 2018

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Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response.

21 January 2018

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Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

21 January 2018

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Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women

21 January 2018

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Effect of μ-opioid receptor A118G polymorphism on the ED50 of epidural sufentanil for labor analgesia

21 January 2018

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Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment

21 January 2018

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The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

21 January 2018

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Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients

21 January 2018

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Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

21 January 2018

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Functional genomics of pain in analgesic drug development and therapy

21 January 2018

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Cluster analysis of multiple experimental pain modalities

21 January 2018

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Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients

21 January 2018

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Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

21 January 2018

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A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain.

21 January 2018

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The International HapMap Project

21 January 2018

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Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures

21 January 2018

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Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery

21 January 2018

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Assessing heterogeneity in meta-analysis: Q statistic or I2 index?

21 January 2018

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Measuring inconsistency in meta-analyses

21 January 2018

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21 January 2018

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Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers

21 January 2018

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The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

21 January 2018

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The antinociceptive effect and adverse drug reactions of oxycodone in human experimental pain in relation to genetic variations in the OPRM1 and ABCB1 genes

21 January 2018

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Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.

21 January 2018

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The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade

21 January 2018

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A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia

21 January 2018

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Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy

21 January 2018

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Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty

21 January 2018

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Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

21 January 2018

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Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.

21 January 2018

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Human opioid μ-receptor A118G polymorphism may protect against central pruritus by epidural morphine for post-cesarean analgesia

21 January 2018

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Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain

21 January 2018

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High post surgical opioid requirements in Crohn's disease are not due to a general change in pain sensitivity

21 January 2018

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Polymorphism of the micro-opioid receptor gene (OPRM1 118A>G) affects fentanyl-induced analgesia during anesthesia and recovery

21 January 2018

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The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.187

Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.187

Human mu-opioid receptor gene A118G polymorphism predicts the efficacy of tramadol/acetaminophen combination tablets (ultracet) in oxaliplatin-induced painful neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.187

Micro opioid receptor A118G polymorphism and post-operative pain: opioids' effects on heterozygous patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.187

Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.187

The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.187

Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.187

21 January 2018

Identifiers

DOI

10.2217/PGS.13.187

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30 August 2017

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