c-MET kinase inhibitors: a patent review (2011 - 2013). (Q38165247)

30 August 2017

title

c-MET kinase inhibitors: a patent review (2011 - 2013). (English)

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30 August 2017

Kongkai Zhu

1

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30 August 2017

Xiangqian Kong

2

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30 August 2017

Dan Zhao

3

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30 August 2017

Zhongjie Liang

4

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30 August 2017

Cheng Luo

5

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30 August 2017

language of work or name

English

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publication date

25 November 2013

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Expert Opinion on Therapeutic Patents

30 August 2017

published in

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30 August 2017

volume

24

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30 August 2017

issue

2

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30 August 2017

page(s)

217-230

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Met, metastasis, motility and more

30 August 2017

cites work

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https://api.crossref.org/works/10.1517%2F13543776.2014.864279

Showering c-MET-dependent cancers with drugs

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Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition

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Molecular cloning of a new transforming gene from a chemically transformed human cell line.

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c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention

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Small molecule c-Met kinase inhibitors: a review of recent patents

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Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma

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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

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Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

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Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay

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NK4 gene therapy targeting HGF-Met and angiogenesis.

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Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent

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Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase

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From concept to reality: the long road to c-Met and RON receptor tyrosine kinase inhibitors for the treatment of cancer

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Listeria InlB takes a different route to met.

21 January 2018

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A new Met inhibitory-scaffold identified by a focused forward chemical biological screen

21 January 2018

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Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling

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Developing c-MET pathway inhibitors for cancer therapy: progress and challenges

21 January 2018

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

21 January 2018

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An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms

21 January 2018

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Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.

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Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates

21 January 2018

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Novel therapeutic inhibitors of the c-Met signaling pathway in cancer

21 January 2018

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A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.

21 January 2018

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Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

21 January 2018

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Characteristics of lung cancers harboring NRAS mutations

21 January 2018

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Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.

21 January 2018

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Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

21 January 2018

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A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients

21 January 2018

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Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway.

21 January 2018

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Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily

21 January 2018

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Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo

21 January 2018

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21 January 2018

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Novel agents on the horizon for cancer therapy

21 January 2018

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Cancer: a Systems Biology disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.864279

From 'omics' to complex disease: a systems biology approach to gene-environment interactions in cancer

21 January 2018

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Network pharmacology for cancer drug discovery: are we there yet?

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.864279

10.1517/13543776.2014.864279

21 January 2018

Identifiers

DOI

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30 August 2017

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