The production and regulation of IgE by the immune system (Q38195702)

30 August 2017

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title

The production and regulation of IgE by the immune system (English)

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30 August 2017

Lawren C Wu

1

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PubMed ID

24625841

30 August 2017

Ali A Zarrin

series ordinal

2

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30 August 2017

14 March 2014

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Nature Reviews Immunology

30 August 2017

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30 August 2017

14

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30 August 2017

4

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30 August 2017

247-259

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IgE in allergy and asthma today

30 August 2017

1 reference

The biology of IGE and the basis of allergic disease

31 March 2020

1 reference

The who, where, and when of IgE in allergic airway disease.

31 March 2020

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A Radioimmunoassay for Evaluation of the IgE and IgG Antibody Responses in the Rat

31 March 2020

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Somatic diversity of the immunoglobulin repertoire is controlled in an isotype-specific manner

31 March 2020

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IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway.

31 March 2020

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Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition.

31 March 2020

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CD23/FcεRII: molecular multi-tasking

31 March 2020

1 reference

New developments in FcepsilonRI regulation, function and inhibition

31 March 2020

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The germinal center reaction

31 March 2020

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Control systems and decision making for antibody production.

31 March 2020

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Molecular programming of B cell memory

31 March 2020

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Plasma cell development and survival.

31 March 2020

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Germinal center selection and the development of memory B and plasma cells

31 March 2020

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31 March 2020

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Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

31 March 2020

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Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway.

31 March 2020

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The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response

31 March 2020

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

31 March 2020

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The regulation of immunoglobulin E class-switch recombination

31 March 2020

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Shutdown of class switch recombination by deletion of a switch region control element.

31 March 2020

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Frequency of immunoglobulin E class switching is autonomously determined and independent of prior switching to other classes

31 March 2020

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Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells

31 March 2020

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DNA sequences at immunoglobulin switch region recombination sites

31 March 2020

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Unique maturation program of the IgE response in vivo

31 March 2020

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Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination

31 March 2020

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The murine IgG1/IgE class switch program

31 March 2020

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Antigen dose-dependent predominance of either direct or sequential switch in IgE antibody responses.

31 March 2020

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Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination.

31 March 2020

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Sequential class switching is required for the generation of high affinity IgE antibodies

31 March 2020

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Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1.

31 March 2020

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Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions

31 March 2020

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Influence of switch region length on immunoglobulin class switch recombination

31 March 2020

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Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

31 March 2020

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DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination

31 March 2020

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Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells

31 March 2020

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Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny

31 March 2020

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Direct and sequential switching from mu to epsilon in patients with Schistosoma mansoni infection and atopic dermatitis

31 March 2020

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Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells.

31 March 2020

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In vivo and in vitro IgE isotype switching in human B lymphocytes: evidence for a predominantly direct IgM to IgE class switch program

31 March 2020

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Effect of transmembrane and cytoplasmic domains of IgE on the IgE response.

31 March 2020

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Migration of antibody secreting cells towards CXCL12 depends on the isotype that forms the BCR.

31 March 2020

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Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells.

31 March 2020

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Antigen-specific immunoglobulin E+ B cells are preferentially localized within germinal centres

31 March 2020

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On the differentiation of mouse IgE⁺ cells.

31 March 2020

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Natural IgE production in the absence of MHC Class II cognate help

31 March 2020

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The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

31 March 2020

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Localization of IgE to lung germinal lymphoid follicles in a patient with allergic bronchopulmonary aspergillosis

31 March 2020

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Germinal-centre reactions in allergic inflammation

31 March 2020

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Long-lived IgE- and IgG-secreting cells in rodents manifesting persistent antibody responses.

31 March 2020

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Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge.

31 March 2020

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T cell-dependent differentiation of human B cells into IgM, IgG, IgA, or IgE plasma cells: high rate of antibody production by IgE plasma cells, but limited clonal expansion of IgE precursors

31 March 2020

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The detection of IgE-secreting cells in the peripheral blood of patients with atopic dermatitis

31 March 2020

1 reference

Detection and characterization of plasma cells in peripheral blood: correlation of IgE+ plasma cell frequency with IgE serum titre

31 March 2020

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Seasonal changes in IgE antibodies and their relationship to IgG antibodies during immunotherapy for ragweed hay fever

31 March 2020

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IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections

31 March 2020

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Transfer of atopy following bone marrow transplantation.

31 March 2020

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Long-term acquisition of allergen-specific IgE and asthma following allogeneic bone marrow transplantation from allergic donors

31 March 2020

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The development of IgE+ memory B cells following primary IgE immune responses.

31 March 2020

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Murine IgG1 and IgE memory B cells.

31 March 2020

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IgE+ cells in the peripheral blood of atopic, nonatopic, and bee venom-hypersensitive individuals exhibit the phenotype of highly differentiated B cells

31 March 2020

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Epstein-Barr virus-induced IgE production in limiting dilution cultures of normal human B cells

31 March 2020

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Allergen-specific IgE production of committed B cells from allergic patients in vitro

31 March 2020

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Plasma cells and nonplasma B cells express differing IgE repertoires in allergic sensitization

31 March 2020

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Antigen selection in the IgE response of allergic and nonallergic individuals

31 March 2020

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IgE transcripts in the circulation of allergic children reflect a classical antigen-driven B cell response and not a superantigen-like activation.

31 March 2020

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The IgE repertoire in PBMCs of atopic patients is characterized by individual rearrangements without variable region of the heavy immunoglobulin chain bias.

31 March 2020

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31 March 2020

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Molecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitis

31 March 2020

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IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection.

31 March 2020

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Antibody repertoire complexity and effector cell biology determined by assays for IgE-mediated basophil and T-cell activation.

31 March 2020

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Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation

31 March 2020

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Induction and regulation of the IgE response

31 March 2020

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The structure of human CD23 and its interactions with IgE and CD21.

31 March 2020

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Murine B cells regulate serum IgE levels in a CD23-dependent manner

31 March 2020

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Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene

31 March 2020

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Serum IgE clearance is facilitated by human FcεRI internalization

31 March 2020

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IgEb immune complexes activate macrophages through FcgammaRIV binding

31 March 2020

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FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation

31 March 2020

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Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.

31 March 2020

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Circular DNA is excised by immunoglobulin class switch recombination

31 March 2020

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Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching

31 March 2020

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Circular DNA is a product of the immunoglobulin class switch rearrangement

31 March 2020

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Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

31 March 2020

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

31 March 2020

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Metabolic study of human IgE: evidence for an extravascular catabolic pathway

31 March 2020

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12 December 2020

Specific and total IgE responses to antigenic stimuli in Brown-Norway, Lewis and Sprague-Dawley rats

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12 December 2020

Biological characterization of mouse 'early' antibodies

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12 December 2020

IL-4 induction of IgE class switching by lipopolysaccharide-activated murine B cells occurs predominantly through sequential switching

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12 December 2020

Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels

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12 December 2020

Human Ig S gamma regions and their participation in sequential switching to IgE.

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12 December 2020

Some factors influencing the serum IgE levels in atopic diseases

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12 December 2020

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching

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12 December 2020

Reaginic antibody production in different mouse strains

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12 December 2020

Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone

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12 December 2020

Mice deficient in CD23 reveal its modulatory role in IgE production but no role in T and B cell development

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12 December 2020

Induction of an IgE response in mice by Nippostrongylus brasiliensis: characterization of lymphoid cells with intracytoplasmic or surface IgE.

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12 December 2020

Identifiers

DOI

10.1038/NRI3632

1 reference

30 August 2017

1 reference

PubMed ID

24625841