Hyaluronic acid conjugates as vectors for the active targeting of drugs, genes and nanocomposites in cancer treatment. (Q38197045)

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11 March 2020

4 references

1 June 2020

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23 November 2020

8 February 2021

Hyaluronic acid conjugates as vectors for the active targeting of drugs, genes and nanocomposites in cancer treatment (English)

1 reference

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11 March 2020

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1 reference

14 September 2020

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23 November 2020

1 reference

8 February 2021

4

1 reference

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11 March 2020

author name string

Silvia Arpicco

series ordinal

1

1 reference

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11 March 2020

Paola Milla

series ordinal

2

1 reference

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11 March 2020

Barbara Stella

series ordinal

3

1 reference

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language of work or name

English

0 references

publication date

17 March 2014

5 references

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11 March 2020

1 June 2020

14 September 2020

23 November 2020

8 February 2021

5 references

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19

1 reference

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issue

3

1 reference

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page(s)

3193-3230

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Creative Commons Attribution

11 March 2020

copyright license

4 references

1 June 2020

14 September 2020

23 November 2020

8 February 2021

0 references

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

1 reference

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Cancer treatment and survivorship statistics, 2012

21 January 2018

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Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects

21 January 2018

1 reference

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Tumor delivery of macromolecular drugs based on the EPR effect

21 January 2018

1 reference

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Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes.

21 January 2018

1 reference

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Polymer-drug conjugates: origins, progress to date and future directions

21 January 2018

1 reference

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Macromolecular therapeutics in cancer treatment: the EPR effect and beyond

21 January 2018

1 reference

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Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells.

21 January 2018

1 reference

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Hyaluronic acid based scaffolds for tissue engineering--a review

21 January 2018

1 reference

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CD44: a validated target for improved delivery of cancer therapeutics

21 January 2018

1 reference

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Hyaluronan regulates cell behavior: a potential niche matrix for stem cells

21 January 2018

1 reference

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21 January 2018

The liberation of CD44.

1 reference

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Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line

21 January 2018

1 reference

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Paclitaxel in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Biodistribution imaging of a paclitaxel-hyaluronan bioconjugate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-paclitaxel: effects of intraperitoneal administration against CD44(+) human ovarian cancer xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

A paclitaxel-hyaluronan bioconjugate targeting ovarian cancer affords a potent in vivo therapeutic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Paclitaxel-hyaluronan hydrosoluble bioconjugate: mechanism of action in human bladder cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-paclitaxel: antitumor efficacy against CD44(+) human ovarian carcinoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Metronomic activity of CD44-targeted hyaluronic acid-paclitaxel in ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

The use of amino acid linkers in the conjugation of paclitaxel with hyaluronic acid as drug delivery system: synthesis, self-assembled property, drug release, and in vitro efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-paclitaxel conjugate micelles: synthesis, characterization, and antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

New Angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

CD44-targeting for antitumor drug delivery: a new SN-38-hyaluronan bioconjugate for locoregional treatment of peritoneal carcinomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

The development of hyaluronan as a drug transporter and excipient for chemotherapeutic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

In situ cross-linkable high molecular weight hyaluronan-bisphosphonate conjugate for localized delivery and cell-specific targeting: a hydrogel linked prodrug approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Tailored doxorubicin-hyaluronan conjugate as a potent anticancer glyco-drug: an alternative to prodrug approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Efficacy and toxicity of peritumoral delivery of nanoconjugated cisplatin in an in vivo murine model of head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Subcutaneous delivery of nanoconjugated doxorubicin and cisplatin for locally advanced breast cancer demonstrates improved efficacy and decreased toxicity at lower doses than standard systemic combination therapy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Boron neutron capture therapy of cancer: current status and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Novel types of carborane-carrier hyaluronan derivatives via "click chemistry".

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Paclitaxel-clusters coated with hyaluronan as selective tumor-targeted nanovectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Development and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid coated poly(butyl cyanoacrylate) nanoparticles as anticancer drug carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Self-assembled nanoparticles of hyaluronic acid/poly(DL-lactide-co-glycolide) block copolymer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Biodegradable self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Theranostic nanoparticles based on PEGylated hyaluronic acid for the diagnosis, therapy and monitoring of colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Efficient simultaneous tumor targeting delivery of all-trans retinoid acid and Paclitaxel based on hyaluronic acid-based multifunctional nanocarrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

CD44-targeted microparticles for delivery of cisplatin to peritoneal metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Polymer shelled microparticles for a targeted doxorubicin delivery in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Molecular and cellular studies of hyaluronic acid-modified liposomes as bioadhesive carriers for topical drug delivery in wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Efficient synthesis of an aldehyde functionalized hyaluronic acid and its application in the preparation of hyaluronan-lipid conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-coated liposomes for active targeting of gemcitabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Targeting gemcitabine containing liposomes to CD44 expressing pancreatic adenocarcinoma cells causes an increase in the antitumoral activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Lipoplexes targeting the CD44 hyaluronic acid receptor for efficient transfection of breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-bearing lipoplexes: physico-chemical characterization and in vitro targeting of the CD44 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-modified DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid and its derivative as a multi-functional gene expression enhancer: protection from non-specific interactions, adhesion to targeted cells, and transcriptional activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

In vivo real-time bioimaging of hyaluronic acid derivatives using quantum dots

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-polyethyleneimine conjugate for target specific intracellular delivery of siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Amphoteric hyaluronic acid derivative for targeting gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Engineering a polymeric gene delivery vector based on poly(ethylenimine) and hyaluronic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(gamma-benzyl L-glutamate)-b-hyaluronan polymersomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Poly[lactic-co-(glycolic acid)]-grafted hyaluronic acid copolymer micelle nanoparticles for target-specific delivery of doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Self-assembled amphiphilic hyaluronic acid graft copolymers for targeted release of antitumoral drug

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Effect of hyaluronic acid molecular weight on the morphology of quantum dot-hyaluronic acid conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Bioimaging for targeted delivery of hyaluronic Acid derivatives to the livers in cirrhotic mice using quantum dots.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Inorganic nanotubes and fullerene-like nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Luminescent Carbon Nanodots: Emergent Nanolights

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Carbon nanotubes for biomedical imaging: the recent advances.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Graphene: status and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Focusing on luminescent graphene quantum dots: current status and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Quantum-sized carbon dots for bright and colorful photoluminescence

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Polyhydroxy fullerenes for non-invasive cancer imaging and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronated fullerenes with photoluminescent and antitumoral activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Carbon nanotubes for delivery of small molecule drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

A facile, one-step nanocarbon functionalization for biomedical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Self-assembled hyaluronic acid nanoparticles for active tumor targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronate tethered, "smart" multiwalled carbon nanotubes for tumor-targeted delivery of doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Surface chemistry dependent "switch" regulates the trafficking and therapeutic performance of drug-loaded carbon nanotubes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

The application of hyaluronic acid-derivatized carbon nanotubes in hematoporphyrin monomethyl ether-based photodynamic therapy for in vivo and in vitro cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-gold nanoparticle/interferon α complex for targeted treatment of hepatitis C virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid immobilized magnetic nanoparticles for active targeting and imaging of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Development of multifunctional hyaluronan-coated nanoparticles for imaging and drug delivery to cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Bioresponsive hyaluronic acid-capped mesoporous silica nanoparticles for targeted drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Development of drug loaded nanoparticles for tumor targeting. Part 1: Synthesis, characterization, and biological evaluation in 2D cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Development of drug loaded nanoparticles for tumor targeting. Part 2: Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronic acid-functionalized mesoporous silica nanoparticles for efficient photodynamic therapy of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Highly Luminescent Water-Soluble CdTe Quantum Dots

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Self-assembled pH-responsive hyaluronic acid-g-poly((L)-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hydrophobic Nanocrystals Coated with an Amphiphilic Polymer Shell: A General Route to Water Soluble Nanocrystals

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES19033193

Hyaluronan binding by cell surface CD44.

21 January 2018

1 reference

12 December 2020

Ligation of the CD44 adhesion molecule inhibits drug-induced apoptosis in human myeloid leukemia cells.

1 reference

12 December 2020

Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells

1 reference

12 December 2020

Approval summary for zoledronic acid for treatment of multiple myeloma and cancer bone metastases.

1 reference

12 December 2020

HYTAD1-p20: a new paclitaxel-hyaluronic acid hydrosoluble bioconjugate for treatment of superficial bladder cancer

1 reference

12 December 2020

Development and characterization of hyaluronic acid-anchored PLGA nanoparticulate carriers of doxorubicin

1 reference

12 December 2020

In vitro and in vivo evaluation of docetaxel loaded biodegradable polymersomes

1 reference

12 December 2020

Paclitaxel-hyaluronic acid for intravesical therapy of bacillus Calmette-Guérin refractory carcinoma in situ of the bladder: results of a phase I study

1 reference

12 December 2020

The in vivo behavior and antitumor activity of doxorubicin-loaded poly(γ-benzyl l-glutamate)-block-hyaluronan polymersomes in Ehrlich ascites tumor-bearing BalB/c mice

1 reference

12 December 2020

Hyaluronic acid-paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism

1 reference

12 December 2020

Pharmacokinetic profile of Oncofid-S after intraperitoneal and intravenous administration in the rat

1 reference

12 December 2020

Bioimaging of hyaluronic acid derivatives using nanosized carbon dots

1 reference

12 December 2020

Hyaluronic acid-decorated PLGA-PEG nanoparticles for targeted delivery of SN-38 to ovarian cancer

1 reference

12 December 2020

Target delivery and cell imaging using hyaluronic acid-functionalized graphene quantum dots

1 reference

12 December 2020

Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

1 reference

12 December 2020

Functionalized derivatives of hyaluronic acid oligosaccharides: drug carriers and novel biomaterials

1 reference

12 December 2020

Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity

1 reference

12 December 2020

CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines

1 reference

12 December 2020

10.3390/MOLECULES19033193

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24642908%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24642908%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PubMed publication ID

24642908

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24642908%20AND%20SRC:MED&resulttype=core&format=json