Understanding the cause of sporadic Alzheimer's disease (Q38213834)

31 August 2017

title

Understanding the cause of sporadic Alzheimer's disease (English)

1 reference

31 August 2017

0 references

1

Henrik Zetterberg

1 reference

31 August 2017

2

Niklas Mattsson

1 reference

31 August 2017

publication date

1 June 2014

1 reference

Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

31 August 2017

published in

1 reference

31 August 2017

volume

14

1 reference

31 August 2017

issue

6

1 reference

31 August 2017

page(s)

621-630

1 reference

Observations on the brains of demented old people

31 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Redundancy and divergence in the amyloid precursor protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Alzheimer's disease and the amyloid β-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Selective disruption of the cerebral neocortex in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Brain atrophy in healthy aging is related to CSF levels of Aβ1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Larger temporal volume in elderly with high versus low beta-amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

CSF biomarker variability in the Alzheimer's Association quality control program

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

A phase 3 trial of semagacestat for treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Neuroimaging results impose new views on Alzheimer's disease--the role of amyloid revised

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Regional brain changes in aging healthy adults: general trends, individual differences and modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

One-year brain atrophy evident in healthy aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Brain changes in older adults at very low risk for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Frequency of stages of Alzheimer-related lesions in different age categories

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Reply: the early pathological process in sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Amyloid and tau: neither chicken nor egg but two partners in crime!

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

A 2-process model for neuropathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

TREM2 Variants in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

SnapShot: genetics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Generation of amyloid β protein from its precursor is sequence specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Effects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Meta-analysis of APOE4 allele and outcome after traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Influence of the apolipoprotein E epsilon4 allele on human embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Distribution of apolipoprotein E alleles in a Scottish healthy newborn population

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

The distribution of apolipoprotein E alleles in Scottish perinatal deaths

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Epidemiology of dementia in Nigeria: results from the Indianapolis-Ibadan study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Two faces of p53: aging and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Cerebrovascular hypoperfusion induces spatial memory impairment, synaptic changes, and amyloid-β oligomerization in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Blood pressure components and changes in relation to white matter lesions: a 32-year prospective population study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Mixed brain pathologies account for most dementia cases in community-dwelling older persons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Dementia from Alzheimer disease and mixed pathologies in the oldest old.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Prevalence and pathology of dementia with Lewy bodies in the oldest old: a comparison with other dementing disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

The neuropathology of probable Alzheimer disease and mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Cognitive decline is faster in Lewy body variant than in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

The pathobiology of vascular dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Characteristic clinical presentation and CSF biomarker pattern in cerebral small vessel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Primary progressive aphasia: clinicopathological correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Clinicopathological correlations in corticobasal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Early-onset Alzheimer disease clinical variants: multivariate analyses of cortical thickness

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Primary progressive aphasia and the language network: the 2013 H. Houston Merritt Lecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Clinical and pathological evidence for a frontal variant of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer’s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

Posterior cortical atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.2014.915740

10.1586/14737175.2014.915740

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

1 reference