How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine-aspartic acid (LD) motifs (Q38215562)

31 August 2017

title

How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine-aspartic acid (LD) motifs (English)

1 reference

31 August 2017

4

1 reference

31 August 2017

Tanvir Alam

1

0 references

Xin Gao

object named as

Xin Gao

series ordinal

3

0 references

author name string

Meshari Alazmi

series ordinal

2

1 reference

31 August 2017

language of work or name

English

0 references

publication date

1 June 2014

1 reference

31 August 2017

1 reference

31 August 2017

volume

460

1 reference

31 August 2017

issue

3

1 reference

31 August 2017

page(s)

317-329

1 reference

31 August 2017

cites work

Paxillin comes of age

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

21 January 2018

The paxillin LD motifs

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin-ARF GAP signaling and the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin LD motifs may define a new family of protein recognition domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The LIM domains of hic-5 protein recognize specific DNA fragments in a zinc-dependent manner in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Ancient origin of the integrin-mediated adhesion and signaling machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Integrin-regulated FAK-Src signaling in normal and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The role of focal adhesion kinase in the regulation of cellular mechanical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Analysis and prediction of leucine-rich nuclear export signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Transformation by bovine papillomavirus type 1 E6 requires paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Integrin signalling: a new Cas(t) of characters enters the stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The structural basis of localization and signaling by the focal adhesion targeting domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Interaction of focal adhesion kinase with cytoskeletal protein talin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

FAK dimerization controls its kinase-dependent functions at focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Multiple paxillin binding sites regulate FAK function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural basis for the interaction between focal adhesion kinase and CD4

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Protein-tyrosine kinase CAKbeta/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 alpha2 helix and thus forming its dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Focal adhesion kinase: exploring Fak structure to gain insight into function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Differential signaling by the focal adhesion kinase and cell adhesion kinase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Crystal structure of the vinculin tail suggests a pathway for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin: a new vinculin-binding protein present in focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Vinculin tail conformation and self-association is independent of pH and H906 protonation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Three-dimensional structure of vinculin bound to actin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

GIT1 Paxillin-binding Domain Is a Four-helix Bundle, and It Binds to Both Paxillin LD2 and LD4 Motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structures of dimeric GIT1 and trimeric beta-PIX and implications for GIT-PIX complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

ILK, PINCH and parvin: the tIPP of integrin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The Structure of -Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural basis for paxillin binding and focal adhesion targeting of β-parvin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin's LD4 motif interacts with bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Recognition of polyadenylate RNA by the poly(A)-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Structural basis for leucine-rich nuclear export signal recognition by CRM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Linkage of caspase-mediated degradation of paxillin to apoptosis in Ba/F3 murine pro-B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin phosphorylation sites mapped by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Alternative splicing controls the mechanisms of FAK autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

In vitro phosphorylation of the focal adhesion targeting domain of focal adhesion kinase by Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Cleavage of focal adhesion kinase by caspases during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Calpain is required for normal osteoclast function and is down-regulated by calcitonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Inhibition of calpain stabilises podosomes and impairs dendritic cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Crystal structure of human vinculin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

Noise in cellular signaling pathways: causes and effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

New Insights into FAK Signaling and Localization Based on Detection of a FAT Domain Folding Intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

The LxxLL motif: a multifunctional binding sequence in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140298

21 January 2018

Identifiers

DOI

10.1042/BJ20140298

1 reference

31 August 2017

1 reference